Displaying toxin 2226 - 2250 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D2754Olanzapine
132539-06-1
C17H20N4S
312.433 g/mol
Thumb
  • Amine
  • Antiemetic
  • Antipsychotic Agent
  • Drug
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Serotonin Uptake Inhibitor
  • Synthetic Compound
Olanzapine's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. A...more
Number of Targets: 36
T3D2755Metixene
4969-02-2
C20H23NS
309.468 g/mol
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  • Amine
  • Antiparkinson Agent
  • Drug
  • Ether
  • Metabolite
  • Muscarinic Antagonist
  • Organic Compound
  • Synthetic Compound
Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of...more
Number of Targets: 5
T3D2756Cetirizine
83881-51-0
C21H25ClN2O3
388.888 g/mol
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  • Amine
  • Anti-Allergic Agent
  • Drug
  • Ether
  • Food Toxin
  • Histamine Antagonist
  • Histamine H1 Antagonist, Non-Sedating
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. Th...more
Number of Targets: 5
T3D2757Terfenadine
50679-08-8
C32H41NO2
471.673 g/mol
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  • Amine
  • Anti-Allergic Agent
  • Anti-Arrhythmia Agent
  • Drug
  • Histamine Antagonist
  • Histamine H1 Antagonist, Non-Sedating
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Terfenadine competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of ter...more
Number of Targets: 11
T3D2758Diltiazem
42399-41-7
C22H26N2O4S
414.518 g/mol
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  • Amide
  • Amine
  • Antihypertensive Agent
  • Calcium Channel Blocker
  • Cardiovascular Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
  • Vasodilator Agent
Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem,...more
Number of Targets: 6
T3D2759Protriptyline
438-60-8
C19H21N
263.377 g/mol
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  • Adrenergic Uptake Inhibitor
  • Amine
  • Antidepressant
  • Antidepressive Agent, Tricyclic
  • Drug
  • Metabolite
  • Norepinephrine Reuptake Inhibitor
  • Organic Compound
  • Synthetic Compound
Protriptyline acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).
Number of Targets: 4
T3D2760Trimethadione
127-48-0
C6H9NO3
143.141 g/mol
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  • Amide
  • Amine
  • Anticonvulsant
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type c...more
Number of Targets: 1
T3D2763Anidulafungin
166663-25-8
C58H73N7O17
1140.237 g/mol
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  • Amide
  • Amine
  • Antibiotic, Antifungal
  • Antifungal Agent
  • Drug
  • Ester
  • Ether
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibits glucan synthase, an enzyme present in fungal, but not mammalian cells. ...more
Number of Targets: 6
T3D2764Clozapine
5786-21-0
C18H19ClN4
326.823 g/mol
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  • Amine
  • Antipsychotic Agent
  • Drug
  • GABA Antagonist
  • Metabolite
  • Organic Compound
  • Organochloride
  • Serotonin Antagonist
  • Synthetic Compound
The mechanism of action of Clozapine, as with other drugs used to treat schizophrenia, is unknown. However, it has been proposed that the drug's therapeutic activity i...more
Number of Targets: 29
T3D2767Mirtazapine
61337-67-5
C17H19N3
265.353 g/mol
Thumb
  • Adrenergic alpha-Antagonist
  • Amine
  • Antidepressive Agent, Tricyclic
  • Drug
  • Food Toxin
  • Histamine H1 Antagonist
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Mirtazapine acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative feedback to the presynaptic nerve and causing an increase in NE relea...more
Number of Targets: 23
T3D2770Trihexyphenidyl
144-11-6
C20H31NO
301.466 g/mol
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  • Amine
  • Antidyskinetic
  • Antiparkinson Agent
  • Drug
  • Metabolite
  • Muscarinic Antagonist
  • Organic Compound
  • Synthetic Compound
Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral mus...more
Number of Targets: 5
T3D2771Dexrazoxane
24584-09-6
C11H16N4O4
268.269 g/mol
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  • Amide
  • Amine
  • Antineoplastic Agent
  • Cardiovascular Agent
  • Chelating Agent
  • Drug
  • Food Toxin
  • Immunosuppressive Agent
  • Metabolite
  • Organic Compound
  • Synthetic Compound
The mechanism by which dexrazoxane exerts its cardioprotective activity is not fully understood. Dexrazoxane is a cyclic derivative of EDTA that readily penetrates cel...more
Number of Targets: 2
T3D2772Tacrine
321-64-2
C13H14N2
198.264 g/mol
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  • Amine
  • Cholinesterase Inhibitor
  • Drug
  • Metabolite
  • Nootropic Agent
  • Organic Compound
  • Parasympathomimetic
  • Synthetic Compound
Tacrine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesteras...more
Number of Targets: 16
T3D2773Procyclidine
77-37-2
C19H29NO
287.440 g/mol
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  • Amine
  • Antidyskinetic
  • Antiparkinson Agent
  • Drug
  • Metabolite
  • Muscarinic Antagonist
  • Organic Compound
  • Synthetic Compound
The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic act...more
Number of Targets: 4
T3D2777Alprazolam
28981-97-7
C17H13ClN4
308.765 g/mol
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  • Anti-Anxiety Agent
  • Benzodiazepine
  • Drug
  • GABA Modulator
  • Hypnotic and Sedative
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects muscle relaxation, anticonvulsant activity, motor ...more
Number of Targets: 23
T3D2779Loxapine
1977-10-2
C18H18ClN3O
327.808 g/mol
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  • Amine
  • Antipsychotic Agent
  • Dopamine Antagonist
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of e...more
Number of Targets: 33
T3D2783Pramipexole
104632-26-0
C10H17N3S
211.327 g/mol
Thumb
  • Amine
  • Antidyskinetic
  • Antioxidant
  • Antiparkinson Agent
  • Dopamine Agonist
  • Drug
  • Free Radical Scavenger
  • Metabolite
  • Organic Compound
  • Synthetic Compound
The precise mechanism of action of Pramipexole as a treatment for Parkinson's disease is unknown, although it is believed to be related to its ability to stimulate dop...more
Number of Targets: 14
T3D2784Secobarbital
76-73-3
C12H18N2O3
238.283 g/mol
Thumb
  • Adjuvant
  • Adjuvant, Anesthesia
  • Amide
  • Amine
  • Barbiturate
  • Drug
  • GABA Modulator
  • Hypnotic and Sedative
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Secobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open....more
Number of Targets: 11
T3D2786Methylphenidate
113-45-1
C14H19NO2
233.306 g/mol
Thumb
  • Adrenergic Agent
  • Adrenergic Uptake Inhibitor
  • Amine
  • Central Nervous System Stimulant
  • Dopamine Uptake Inhibitor
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Sympathomimetic
  • Synthetic Compound
Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal...more
Number of Targets: 3
T3D2787Zolpidem
82626-48-0
C19H21N3O
307.390 g/mol
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  • Amide
  • Amine
  • Drug
  • Food Toxin
  • GABA Agonist
  • GABA-A Receptor Agonist
  • Hypnotic and Sedative
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Zolpidem modulates the alpha-subunit, known as the benzodiazepine receptor, within the GABAA receptor chloride channel macromolecular complex. Unlike the benzodiazepin...more
Number of Targets: 7
T3D2788Streptozocin
18883-66-4
C8H15N3O7
265.221 g/mol
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  • Amine
  • Antibiotic
  • Antibiotic, Antineoplastic
  • Antineoplastic Agent
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Streptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas. It is used in medical research to prod...more
Number of Targets: 3
T3D2789Prochlorperazine
58-38-8
C20H24ClN3S
373.943 g/mol
Thumb
  • Amine
  • Antiemetic
  • Antipsychotic Agent
  • Dopamine Antagonist
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Phenothiazine
  • Synthetic Compound
The mechanism of action of prochlorperazine has not been fully determined, but may be primarily related to its antidopaminergic effects. Prochlorperazine blocks the D2...more
Number of Targets: 9
T3D2790Cyproheptadine
129-03-3
C21H21N
287.398 g/mol
Thumb
  • Amine
  • Anti-Allergic Agent
  • Antihistamine Derivative
  • Antipruritic
  • Drug
  • Food Toxin
  • Gastrointestinal Agent
  • Histamine H1 Antagonist
  • Metabolite
  • Organic Compound
  • Serotonin Antagonist
  • Synthetic Compound
Cyproheptadine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the ...more
Number of Targets: 17
T3D2791Epirubicin
56420-45-2
C27H29NO11
543.519 g/mol
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  • Amine
  • Antibiotic, Antineoplastic
  • Antineoplastic Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Epirubicin has antimitotic and cytotoxic activity. It inhibits nucleic acid (DNA and RNA) and protein synthesis through a number of proposed mechanisms of action: Epir...more
Number of Targets: 3
T3D2795Meperidine
57-42-1
C15H21NO2
247.333 g/mol
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  • Adjuvant
  • Adjuvant, Anesthesia
  • Amine
  • Analgesic
  • Analgesic, Opioid
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Narcotic
  • Opiate Agonist
  • Organic Compound
  • Synthetic Compound
Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects. Meperidine has more affinity for the kappa-receptor than morphine. Opiat...more
Number of Targets: 15
Displaying toxin 2226 - 2250 of 3678 in total