Browsing Toxins
Displaying toxin 2226 - 2250 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2754 | Olanzapine 132539-06-1 | C17H20N4S 312.433 g/mol |  |
| Olanzapine's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. A...more Number of Targets: 36 |
| T3D2755 | Metixene 4969-02-2 | C20H23NS 309.468 g/mol |  |
| Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of...more Number of Targets: 5 |
| T3D2756 | Cetirizine 83881-51-0 | C21H25ClN2O3 388.888 g/mol |  |
| Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. Th...more Number of Targets: 5 |
| T3D2757 | Terfenadine 50679-08-8 | C32H41NO2 471.673 g/mol |  |
| Terfenadine competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of ter...more Number of Targets: 11 |
| T3D2758 | Diltiazem 42399-41-7 | C22H26N2O4S 414.518 g/mol |  |
| Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem,...more Number of Targets: 6 |
| T3D2759 | Protriptyline 438-60-8 | C19H21N 263.377 g/mol |  |
| Protriptyline acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). Number of Targets: 4 |
| T3D2760 | Trimethadione 127-48-0 | C6H9NO3 143.141 g/mol |  |
| Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type c...more Number of Targets: 1 |
| T3D2763 | Anidulafungin 166663-25-8 | C58H73N7O17 1140.237 g/mol |  |
| Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibits glucan synthase, an enzyme present in fungal, but not mammalian cells. ...more Number of Targets: 6 |
| T3D2764 | Clozapine 5786-21-0 | C18H19ClN4 326.823 g/mol |  |
| The mechanism of action of Clozapine, as with other drugs used to treat schizophrenia, is unknown. However, it has been proposed that the drug's therapeutic activity i...more Number of Targets: 29 |
| T3D2767 | Mirtazapine 61337-67-5 | C17H19N3 265.353 g/mol |  |
| Mirtazapine acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative feedback to the presynaptic nerve and causing an increase in NE relea...more Number of Targets: 23 |
| T3D2770 | Trihexyphenidyl 144-11-6 | C20H31NO 301.466 g/mol |  |
| Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral mus...more Number of Targets: 5 |
| T3D2771 | Dexrazoxane 24584-09-6 | C11H16N4O4 268.269 g/mol |  |
| The mechanism by which dexrazoxane exerts its cardioprotective activity is not fully understood. Dexrazoxane is a cyclic derivative of EDTA that readily penetrates cel...more Number of Targets: 2 |
| T3D2772 | Tacrine 321-64-2 | C13H14N2 198.264 g/mol |  |
| Tacrine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesteras...more Number of Targets: 16 |
| T3D2773 | Procyclidine 77-37-2 | C19H29NO 287.440 g/mol |  |
| The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic act...more Number of Targets: 4 |
| T3D2777 | Alprazolam 28981-97-7 | C17H13ClN4 308.765 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects muscle relaxation, anticonvulsant activity, motor ...more Number of Targets: 23 |
| T3D2779 | Loxapine 1977-10-2 | C18H18ClN3O 327.808 g/mol |  |
| Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of e...more Number of Targets: 33 |
| T3D2783 | Pramipexole 104632-26-0 | C10H17N3S 211.327 g/mol |  |
| The precise mechanism of action of Pramipexole as a treatment for Parkinson's disease is unknown, although it is believed to be related to its ability to stimulate dop...more Number of Targets: 14 |
| T3D2784 | Secobarbital 76-73-3 | C12H18N2O3 238.283 g/mol |  |
| Secobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open....more Number of Targets: 11 |
| T3D2786 | Methylphenidate 113-45-1 | C14H19NO2 233.306 g/mol |  |
| Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal...more Number of Targets: 3 |
| T3D2787 | Zolpidem 82626-48-0 | C19H21N3O 307.390 g/mol |  |
| Zolpidem modulates the alpha-subunit, known as the benzodiazepine receptor, within the GABAA receptor chloride channel macromolecular complex. Unlike the benzodiazepin...more Number of Targets: 7 |
| T3D2788 | Streptozocin 18883-66-4 | C8H15N3O7 265.221 g/mol |  |
| Streptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas. It is used in medical research to prod...more Number of Targets: 3 |
| T3D2789 | Prochlorperazine 58-38-8 | C20H24ClN3S 373.943 g/mol |  |
| The mechanism of action of prochlorperazine has not been fully determined, but may be primarily related to its antidopaminergic effects. Prochlorperazine blocks the D2...more Number of Targets: 9 |
| T3D2790 | Cyproheptadine 129-03-3 | C21H21N 287.398 g/mol |  |
| Cyproheptadine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the ...more Number of Targets: 17 |
| T3D2791 | Epirubicin 56420-45-2 | C27H29NO11 543.519 g/mol |  |
| Epirubicin has antimitotic and cytotoxic activity. It inhibits nucleic acid (DNA and RNA) and protein synthesis through a number of proposed mechanisms of action: Epir...more Number of Targets: 3 |
| T3D2795 | Meperidine 57-42-1 | C15H21NO2 247.333 g/mol |  |
| Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects. Meperidine has more affinity for the kappa-receptor than morphine. Opiat...more Number of Targets: 15 |