| Version |
Version of T3DB |
| Creation Date |
Date the ToxinCard entry was created |
| Update Date |
Date the ToxinCard was last updated |
| Title/T3DB ID |
Primary accession number consisting of a 3 character prefix (T3D) and a 5 number suffix. |
| Common Name |
Standard name of toxin |
| Compound Type |
The category of the toxin |
| Description |
Description of the toxin describing its composition and/or preparation |
| Synonyms |
Alternate names of the toxin |
| Chemical IUPAC Name |
IUPAC or standard chemical name for the toxin |
| Chemical Formula |
Chemical formula describing atomic or elemental composition |
| Chemical Structure |
Image of the toxin structure |
| INCHI ID |
IUPAC approved InCHI identifier |
| CAS Registry Number |
Chemical Abstract Service identification number |
| PubChem ID |
NCBI's PubChem database identification number (if molecule is in PubChem) |
| KEGG |
The Kyoto Encyclopedia of Genes and Genomes identification number for the toxin |
| UniProt ID |
The UniProt identification number for the protein toxin |
| OMIM ID |
The Online Mendelian Inheritance in Man identification number for the toxin |
| ChEBI ID |
The Chemical Entities of Biological Interest identification number for the toxin |
| BioCyc ID |
The BioCyc identification number for the toxin |
| SuperToxic ID |
The SuperToxic identification number for the toxin |
| CTD ID |
The Comparative Toxicogenomics Database identification number for the toxin |
| Stitch ID |
The Search Tool for Interactions of Chemicals identification number for the toxin |
| DrugBank ID |
The DrugBank identification number for the toxin |
| PDB ID |
The Protein Data Bank identification number for the toxin |
| ACToR ID |
The Aggregated Computational Toxicology Resource identification number for the toxin |
| Wikipedia Link |
Hyperlink to Wikipedia's encyclopedic entry for the Toxin |
| Average Molecular Weight |
Molecular weight in g/mol, determined from molecular formula |
| Monoisotopic Molecular Weight |
The sum of the masses of the atoms in a molecule using the unbound, ground-state, rest mass of the principle (most abundant) isotope for each element instead of the isotopic average mass. |
| Solubility |
water solubility in mg/mL using ALOGPS solubility predictor |
| LogP/Hydrophobicity |
Water/octanol partition coefficient determined using JChem logp predictor |
| MOL File |
Text version of toxin structure in Mol file format |
| PDB File |
Image of toxin's 3D structure in PDB format, calculated using JChem |
| SMILES |
Canonical SMILES string corresponding to toxin structure |
| Appearance |
Outward or visible aspect of the toxin |
| Melting Point |
Melting point (if solid) or boiling point (if liquid) in degrees Celsius |
| Route of Exposure |
Description of how the toxin enters the human body |
| Mechanism of Toxicity |
Description of how the toxin works or what it binds to at a molecular level |
| Metabolism |
The biotransformation of the toxin after it enters the body |
| Toxicity Values |
Experimental toxicity values of the toxin. Usually LD50 or LC50 values |
| Lethal Dose |
The dose that would cause death in a human being |
| Carcinogenicity |
The level to which the toxin is invovled in the promotion of cancer or in the increase of its propagation. The scale displayed is the IARC Classification. |
| Uses/Sources |
Description of how humans commonly encounter the toxin - how the toxin is used or in what products they are found |
| Minimum Risk Level |
An estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse noncancer health effects over a specified duration of exposure |
| Health Effects |
The long term physiological deficiencies, damage or problems caused by the toxin |
| Symptoms |
The immediate and short term physiological effects of the toxin |
| Treatment |
Possible care provided to improve symptoms and health effects caused by the toxin (especially medical procedures or applications that are intended to relieve illness or injury) |
| General References |
References for the information retrieved for the toxin. Journal articles are hyperlinked to PubMed. |
| Targets |
Substances that the toxin chemically binds to |
| Name |
Name of the protein or macromolecule (or other small molecule) that the toxin is supposed to act upon. Some toxins act on multiple targets, so these fields may be repeated several times, reflecting the number of toxin targets a specific toxin may have. |
| Gene Name |
Gene name of toxin target |
| Synonyms |
Alternate names (protein names, abbreviations, etc.) of the toxin target |
| Sequence |
Sequence (protein or DNA) of the toxin target |
| Number of Residues |
Number of amino acids (usually) in the toxin target |
| Molecular Weight (Daltons) |
Molecular weight of the toxin target given in Daltons or g/mol |
| Theoretical pI |
Theoretical isoelectric point of the toxin target |
| GO Classification |
Gene ontology classification of the toxin target including function, cellular process and location |
| General Function |
Short 3-4 word summary of the toxin target's primary functions |
| Specific Function |
Detailed 30-40 word summary of the toxin target's specific functions |
| Pathway |
Key pathways or processes (determined primarily from KEGG) that the toxin target is involved in. |
| Reaction |
Reaction(s) that the toxin target participates in |
| Pfam Domain Function |
Names and ID numbers of PFAM domains found in the toxin target |
| Signals |
Location of signal peptide or other localization signals in the toxin target sequence |
| Transmembrane Regions |
Number and location of the toxin target's transmembrane helices |
| Essentiality |
Importance or essentialness of the toxin target in terms of the organism's ability to survive without it |
| GenBank ID Protein |
GenBank protein ID for the toxin target (if it exists) |
| SwissProt ID |
SwissProt ID for the toxin target (if it exists) |
| SwissProt Name |
SwissProt protein name for the toxin target (if it exists) |
| PDB ID |
PDB ID for the toxin target (if it exists) |
| Cellular Location |
Location of the toxin target inside or around the cell (cytoplasm, nucleus, membrane, etc.) |
| Gene Sequence |
DNA sequence (from cDNA) of the toxin target |
| GenBank ID Gene |
GenBank gene ID for the toxin target |
| GeneCard ID |
GeneCard ID for the toxin target |
| GenAtlas ID |
GenAtlas ID for the toxin target |
| HGNC ID |
HGNC ID for the toxin target |
| Chromosome Location |
Location of the toxin target on any of the 23 human chromosomes (no location is given if the toxin target is bacterial) |
| Locus |
More detailed location of the chromosomal position of the toxin target |
| References |
Pubmed references for the toxin target |
