Browsing Toxins By Category
Displaying toxin 1701 - 1725 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3951 | Demeclocycline 127-33-3 | C21H21ClN2O8 464.853 g/mol |  |
| Tetracyclines target the 28S small subunit of the mitochondrial ribosome thereby deactivation mitochondrial protein synthesis. As a result tetracyclines are cytotoxic ...more Number of Targets: 1 |
| T3D2546 | Dendrotoxin (Dendroaspis angusticeps) 74504-53-3 | Not Available 3417.825 g/mol |  |
| Dendrotoxins block particular subtypes of voltage-gated potassium channels in neurons, thereby prolonging the duration of action potentials and enhancing the release o...more Number of Targets: 23 |
| T3D2545 | Dendrotoxin (Dendroaspis polylepis polylepis) 119128-61-9 | Not Available 7155.305 g/mol |  |
| Dendrotoxins block particular subtypes of voltage-gated potassium channels in neurons, thereby prolonging the duration of action potentials and enhancing the release o...more Number of Targets: 23 |
| T3D4958 | Deoxyadenosine 958-09-8 | C10H13N5O3 251.242 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D4278 | Deoxyadenosine triphosphate 1927-31-7 | C10H16N5O12P3 491.182 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4961 | Deoxycholic acid 83-44-3 | C24H40O4 392.572 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D4245 | Deoxycorticosterone 64-85-7 | C21H30O3 330.461 g/mol |  |
| Not Available Number of Targets: 6 |
| T3D3668 | Deoxynivalenol 51481-10-8 | C15H20O6 296.316 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D4430 | Deoxyuridine triphosphate 1173-82-6 | C9H15N2O14P3 468.142 g/mol |  |
| Deoxyuridine triphosphate (dUTP) can be misincorporated into DNA and cause DNA damage. The extent of DNA damage caused by dUTP is dependent on the levels of the pyroph...more Number of Targets: 3 |
| T3D2606 | Dermonecrotic toxin (Pasteurella multocida) Not Available | Not Available 146382.000 g/mol |  |
| Stimulation of several signalling pathways is induced by PMT. Most remarkable is a potent mitogenic effect. Phospholipase C-beta and the small GTPase Rho are activated...more Number of Targets: 5 |
| T3D3013 | Desflurane 57041-67-5 | C3H2F6O 168.038 g/mol |  |
| Desflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Desflurane...more Number of Targets: 8 |
| T3D2996 | Desipramine 50-47-5 | C18H22N2 266.381 g/mol |  |
| Desipramine is a tricyclic antidepressant (TCA) that selectively blocks reuptake of norepinephrine (noradrenaline) from the neuronal synapse. It also inhibits serotoni...more Number of Targets: 25 |
| T3D4557 | Desloratadine 100643-71-8 | C19H19ClN2 310.821 g/mol |  |
| Like other H1-blockers, Desloratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscl...more Number of Targets: 3 |
| T3D0955 | Desmedipham 13684-56-5 | C16H16N2O4 300.309 g/mol |  |
| Desmedipham is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active site...more Number of Targets: 4 |
| T3D4982 | Dexamethasone 50-02-2 | C22H29FO5 392.461 g/mol |  |
| Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. ...more Number of Targets: 7 |
| T3D3014 | Dexfenfluramine 3239-44-9 | C12H16F3N 231.257 g/mol |  |
| Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor...more Number of Targets: 4 |
| T3D4563 | Dexmethylphenidate 40431-64-9 | C14H19NO2 233.306 g/mol |  |
| Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal...more Number of Targets: 3 |
| T3D2771 | Dexrazoxane 24584-09-6 | C11H16N4O4 268.269 g/mol |  |
| The mechanism by which dexrazoxane exerts its cardioprotective activity is not fully understood. Dexrazoxane is a cyclic derivative of EDTA that readily penetrates cel...more Number of Targets: 2 |
| T3D3051 | Dextroamphetamine 51-64-9 | C9H13N 135.206 g/mol |  |
| The exact mechanism of action is not known. Dextroamphetamine stimulates the release of norepinephrine from central adrenergic receptors. At higher dosages, it causes ...more Number of Targets: 6 |
| T3D2815 | Dextromethorphan 125-71-3 | C18H25NO 271.397 g/mol |  |
| Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 rec...more Number of Targets: 17 |
| T3D0076 | Di(2-ethylhexyl)phthalate 117-81-7 | C24H38O4 390.556 g/mol |  |
| Monoethylhexylphthalate (MEHP), one of the major metabolites of DEHP, induces peroxisome proliferation by activating peroxisome proliferator activated receptors. This ...more Number of Targets: 17 |
| T3D3641 | Di(n-octyl) phthalate 117-84-0 | C24H38O4 390.556 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 1 |
| T3D0956 | Di-allate 2303-16-4 | C10H17Cl2NOS 270.219 g/mol |  |
| The metabolic products of triallate, diallate and sulfallate appear to be mutagenic or carcinogenic. In particular, the 2-chloro-allyl group is responsible for the mu...more Number of Targets: 3 |
| T3D3653 | Di-n-hexyl phthalate 84-75-3 | C20H30O4 334.450 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 10 |
| T3D1255 | Di-n-octyltin dichloride 3542-36-7 | C16H34Cl2Sn 416.060 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 12 |