| Record Information |
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| Version | 2.0 |
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| Creation Date | 2009-06-17 23:53:02 UTC |
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| Update Date | 2014-12-24 20:22:59 UTC |
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| Accession Number | T3D0956 |
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| Identification |
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| Common Name | Di-allate |
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| Class | Small Molecule |
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| Description | Diallate is a thiocarbamate herbicide used to control weeds and grasses amongst crops. It can be applied to the soil before planting or to the growing crops. It is used on alfalfa, alsike clover, barley, corn, flax, soybeans, lentils, peas, potatoes, red clover, sugar beets and sweet clover. Thiocarbamates are mainly used in agriculture as insecticides, herbicides, and fungicides. Additional uses are as biocides for industrial or other commercial applications, and in household products. Some are used for vector control in public health. Thiocarbamates are mostly liquids or solids with low melting points.
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| Compound Type | - Carbamate
- Ether
- Herbicide
- Organic Compound
- Organochloride
- Synthetic Compound
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| Chemical Structure | |
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| Synonyms | | Synonym | | 2,3-DCDT | | 2,3-Dichlorallyl-N,N-(diisopropyl)-thiocarbamate | | 2,3-Dichloro-2-propene-1-thiol, diisopropylcarbamate | | 2,3-Dichloro-2-Propene-1-Thiol, S-2,3-Diisopropyl carbamate | | 2,3-Dichloroallyl Diisopropylthiocarbamate | | 2,3-Dichloroallyl N,N-diisopropylthiolcar bamate | | 2,3-Dichloroallyl N,N-diisopropylthiolcarbamate | | 2-Propene-1-thiol, 2,3-dichloro-, diisopropylcarbamate | | Avadex | | Avadex I | | Avadex II | | Caswell No. 299 | | Cis-diallate | | DATC | | DCDT | | Di-allic acid | | Di-isopropylthiolocarbamate de S-(2,3-dichloro allyle) | | Diallaat | | Diallat | | Diallate | | Dichloroallyl dIIsopropylthiocarbamate | | Diisopropylthiocarbamic acid, S-(2,3-dichloroallyl) ester | | Propene-1-thiol, 2,3-dichloro-, diisopropylcarbamate | | Pyradex | | RCRA waste no. U062 | | Rcra waste number U062 | | S-(2,3-Dichlor-allyl)-N,N-diisopropyl-monothiocarbamaat | | S-(2,3-Dichloro-allil)-N,N-diisopropil-monotiocarbammato | | S-(2,3-Dichloroallyl) diisopropyl-thiocarbamate | | S-(2,3-Dichloroallyl) Diisopropylthiocarbamate | | S-2,3-Dichloroallyl diisopropylthiocarbamate | | S-2,3-Dichloroallyl N,N-diisopropylthiolcarbamate | | S-[(2Z)-2,3-Dichloro-2-propenyl] diisopropylthiocarbamate | | S-[2,3-dichloroprop-2-en-1-yl] diisopropylthiocarbamate |
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| Chemical Formula | C10H17Cl2NOS |
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| Average Molecular Mass | 270.219 g/mol |
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| Monoisotopic Mass | 269.041 g/mol |
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| CAS Registry Number | 2303-16-4 |
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| IUPAC Name | N,N-bis(propan-2-yl){[(2Z)-2,3-dichloroprop-2-en-1-yl]sulfanyl}formamide |
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| Traditional Name | N,N-diisopropyl{[(2Z)-2,3-dichloroprop-2-en-1-yl]sulfanyl}formamide |
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| SMILES | CC(C)N(C(C)C)C(=O)SC\C(Cl)=C\Cl |
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| InChI Identifier | InChI=1S/C10H17Cl2NOS/c1-7(2)13(8(3)4)10(14)15-6-9(12)5-11/h5,7-8H,6H2,1-4H3/b9-5- |
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| InChI Key | InChIKey=SPANOECCGNXGNR-UITAMQMPSA-N |
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| Chemical Taxonomy |
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| Description | belongs to the class of organic compounds known as thiocarbamic acid derivatives. These are organic compounds containing a functional group with the general structure OC(=S)NR2 or SC(=O)NR2. |
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| Kingdom | Organic compounds |
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| Super Class | Organosulfur compounds |
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| Class | Thiocarbonyl compounds |
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| Sub Class | Thiocarbamic acid derivatives |
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| Direct Parent | Thiocarbamic acid derivatives |
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| Alternative Parents | |
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| Substituents | - Carbonic acid derivative
- Thiocarbamic acid derivative
- Vinyl chloride
- Vinyl halide
- Sulfenyl compound
- Chloroalkene
- Haloalkene
- Carbonyl group
- Hydrocarbon derivative
- Organic oxide
- Organopnictogen compound
- Organic oxygen compound
- Organooxygen compound
- Organonitrogen compound
- Organochloride
- Organohalogen compound
- Organic nitrogen compound
- Aliphatic acyclic compound
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| Molecular Framework | Aliphatic acyclic compounds |
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| External Descriptors | |
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| Biological Properties |
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| Status | Detected and Not Quantified |
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| Origin | Exogenous |
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| Cellular Locations | |
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| Biofluid Locations | Not Available |
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| Tissue Locations | Not Available |
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| Pathways | Not Available |
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| Applications | Not Available |
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| Biological Roles | Not Available |
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| Chemical Roles | Not Available |
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| Physical Properties |
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| State | Liquid |
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| Appearance | Amber liquid |
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| Experimental Properties | | Property | Value |
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| Melting Point | 25°C | | Boiling Point | Not Available | | Solubility | 0.014 mg/mL at 25°C [WORTHING,CR & WALKER,SB (1983)] | | LogP | Not Available |
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| Predicted Properties | |
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| Spectra |
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| Spectra | | Spectrum Type | Description | Splash Key | Deposition Date | View |
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| Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-00dl-1790000000-cf1cb2e692c20b2be8c7 | 2016-08-03 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-004l-3930000000-23107a784f899293598b | 2016-08-03 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0006-9800000000-9e2af06a3701aa16b03f | 2016-08-03 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-01di-0960000000-0649f3d608161e6f9efa | 2016-08-03 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-004l-1920000000-e22dfd9b4a3470bf108a | 2016-08-03 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-005i-9700000000-1b03e08d5a7318afa569 | 2016-08-03 | View Spectrum | | MS | Mass Spectrum (Electron Ionization) | splash10-000f-9210000000-d04d68947e99c3684ac6 | 2014-09-20 | View Spectrum |
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| Toxicity Profile |
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| Route of Exposure | Inhalation (1) ; oral (1); dermal (1) |
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| Mechanism of Toxicity | The metabolic products of triallate, diallate and sulfallate appear to be mutagenic or carcinogenic. In particular, the 2-chloro-allyl group is responsible for the mutagenicity of these herbicides. These metabolites likely bind to or disrupt DNA causes base-pair subsitutions. Diallate has been shown to be a carcinogen in mice. Some thiocarbamates (EPTC, Molinate, Pebulate, and Cycloate) share a common mechanism of toxicity, i.e. the inhibition of acetylcholinesterase. An acetylcholinesterase inhibitor suppresses the action of acetylcholine esterase. Because of its essential function, chemicals that interfere with the action of acetylcholine esterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. |
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| Metabolism | As a general rule, thiocarbamates can be absorbed via the skin, mucous membranes, and the respiratory and gastrointestinal tracts. They are eliminated quite rapidly, mainly via expired air and urine. Two major pathways exist for the metabolism of thiocarbamates in mammals. One is via sulfoxidation and conjugation with glutathione. The conjugation product is then cleaved to a cysteine derivative, which is metabolized to a mercapturic acid compound. The second route is oxidation of the sulfur to a sulfoxide, which is then oxidized to a sulfone, or hydroxylation to compounds that enter the carbon metabolic pool. |
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| Toxicity Values | Not Available |
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| Lethal Dose | Not Available |
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| Carcinogenicity (IARC Classification) | 3, not classifiable as to its carcinogenicity to humans. (3) |
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| Uses/Sources | Thiocarbamates are widely used throughout the world and are produced in great quantities, mainly as herbicides and fungicides. |
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| Minimum Risk Level | Not Available |
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| Health Effects | Diallate is carcinogenic. Data concerning the effects of thiocarbamates on man are scarce. However, cases of irritation and sensitization have been observed among agricultural workers. Some thiocarbamates, e.g., molinate, have an effect on sperm morphology and, consequently, on reproduction. However, no teratogenic effects have been observed. The results of mutagenicity studies have shown that thiocarbamates containing dichloroallyl groups are highly mutagenic. Some thiocarbamates are acetylcholine esterase inhibitors. Acute exposure to cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved.
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| Symptoms | As with organophosphates, the signs and symptoms are based on excessive cholinergic stimulation. Unlike organophosphate poisoning, carbamate poisonings tend to be of shorter duration because the inhibition of nervous tissue acetylcholinesterase is reversible, and carbamates are more rapidly metabolized. Muscle weakness, dizziness, sweating and slight body discomfort are commonly reported early symptoms. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Contraction of the pupils with blurred vision, incoordination, muscle twitching and slurred speech have been reported. (2) |
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| Treatment | Treatment of carbamate poisoning is similar to that of organophosphate poisoning in that atropine sulfate injections readily reverse the effects. For acute exposures and first aid: EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. |
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| Normal Concentrations |
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| Not Available |
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| Abnormal Concentrations |
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| Not Available |
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| External Links |
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| DrugBank ID | Not Available |
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| HMDB ID | Not Available |
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| PubChem Compound ID | 5284376 |
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| ChEMBL ID | CHEMBL2252931 |
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| ChemSpider ID | 4447452 |
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| KEGG ID | C19094 |
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| UniProt ID | Not Available |
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| OMIM ID | |
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| ChEBI ID | Not Available |
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| BioCyc ID | CPD-9439 |
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| CTD ID | C004755 |
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| Stitch ID | Di-allate |
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| PDB ID | Not Available |
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| ACToR ID | 395 |
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| Wikipedia Link | Not Available |
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| References |
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| Synthesis Reference | Not Available |
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| MSDS | T3D0956.pdf |
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| General References | - IPCS Intox Database (1987). Antimony pentoxide. [Link]
- Fishel F (2009). Pesticide Toxicity Profile: Carbamate Pesticides. University of Florida, IFAS Extension. [Link]
- International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. [Link]
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| Gene Regulation |
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| Up-Regulated Genes | Not Available |
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| Down-Regulated Genes | Not Available |
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