Browsing Toxins By Category
Displaying toxin 1001 - 1025 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0760 | Ammonium thiocyanate 1762-95-4 | CH4N2S 76.121 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 42 |
| T3D4561 | Amobarbital 57-43-2 | C11H18N2O3 226.272 g/mol |  |
| Amobarbital (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GA...more Number of Targets: 10 |
| T3D0131 | Amosite asbestos 12172-73-5 | (Na, K)0-1(Fe2+, Mg)2(Fe2+, Mg)5Si8O22(OH)2, approx. Fe2+5Mg2 Not Available |  |
| When asbestos fibers are inhaled, many are deposited on the epithelial surface of the respiratory tree. Fibers that are retained in the lung or mesothelium for long pe...more Number of Targets: 1 |
| T3D2819 | Amoxapine 14028-44-5 | C17H16ClN3O 313.781 g/mol |  |
| Amoxapine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). Number of Targets: 25 |
| T3D2706 | Amphetamine 300-62-9 | C9H13N 135.206 g/mol |  |
| Amphetamines stimulate the release of norepinephrine from central adrenergic receptors. At higher dosages, they cause release of dopamine from the mesocorticolimbic sy...more Number of Targets: 14 |
| T3D2863 | Amprenavir 161814-49-9 | C25H35N3O6S 505.627 g/mol |  |
| Amprenavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Number of Targets: 5 |
| T3D4674 | Amsacrine 51264-14-3 | C21H19N3O3S 393.459 g/mol |  |
| Amsacrine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive...more Number of Targets: 3 |
| T3D0813 | Amygdalin 29883-15-6 | C20H27NO11 457.429 g/mol |  |
| Amygdalin can be metabolized into hydrogen cyanide in the stomach causing discomfort or illness. (L402) Organic nitriles decompose into cyanide ions both in vivo and i...more Number of Targets: 0 |
| T3D3108 | Anabasine 13078-04-1 | C10H14N2 162.232 g/mol |  |
| Anabasine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 16 |
| T3D4796 | Anastrozole 120511-73-1 | C17H19N5 293.366 g/mol |  |
| Anastrozole selectively inhibits aromatase. The principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-generated androstenedione to ...more Number of Targets: 2 |
| T3D4124 | Anatoxin a 64285-06-9 | C10H15NO 165.232 g/mol |  |
| Anatoxin-a is an agonist of both neuronal α4β2 and α4 nicotinic acetylcholine receptors present in the CNS as well as the α12βγδ muscle-type nAchRs that are present at...more Number of Targets: 1 |
| T3D4138 | Anatoxin-a(s) 103170-78-1 | C7H17N4O4P 252.208 g/mol |  |
| Anatoxin-a(s) is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholine...more Number of Targets: 0 |
| T3D4240 | Androstenedione 63-05-8 | C19H26O2 286.409 g/mol |  |
| Androstenedione is converted to testosterone and estrogen, and when taken in sufficient quantities androstenedione can cause unwanted masculinizing and feminizing effe...more Number of Targets: 11 |
| T3D0815 | Angelicin 523-50-2 | C11H6O3 186.164 g/mol |  |
| The mechanism of action many furocoumarins is based on their ability to form photoadducts with DNA and other cellular components such as RNA, proteins, and several pro...more Number of Targets: 4 |
| T3D2763 | Anidulafungin 166663-25-8 | C58H73N7O17 1140.237 g/mol |  |
| Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibits glucan synthase, an enzyme present in fungal, but not mammalian cells. ...more Number of Targets: 6 |
| T3D3793 | Anilazine 101-05-3 | C9H5Cl3N4 275.522 g/mol |  |
| Anilazine was found to be mutagenic. Number of Targets: 2 |
| T3D2929 | Anileridine 144-14-9 | C22H28N2O2 352.470 g/mol |  |
| Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more Number of Targets: 1 |
| T3D4984 | Aniline 62-53-3 | C6H7N 93.127 g/mol |  |
| Aniline induces lipid peroxidation and protein oxidation in the spleen and that oxidative stress plays a role in the splenic toxicity of aniline. The hematopoietic sys...more Number of Targets: 2 |
| T3D3074 | Anisatin 5230-87-5 | C15H20O8 328.315 g/mol |  |
| Anisatin acts as a GABA system antagonist. It binds non-competitively to the picrotoxinin site of the GABA receptor, prolonging the closed time of the receptor channel...more Number of Targets: 19 |
| T3D0632 | Anthanthrene 191-26-4 | C22H12 276.331 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D0795 | Anthophyllite Asbestos 77536-67-5 | (Na, K)0-1Mg2(Mg, Fe)5Si8O22(OH)2, Mg/(Mg + Fe) > 0.6 Not Available |  |
| When asbestos fibers are inhaled, many are deposited on the epithelial surface of the respiratory tree. Fibers that are retained in the lung or mesothelium for long pe...more Number of Targets: 1 |
| T3D2589 | Anthopleurin (Anthopleura xanthogrammica) 600880-63-9 | Not Available 5137.770 g/mol |  |
| Anthopleurin binds specifically to the voltage-gated sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of m...more Number of Targets: 14 |
| T3D0619 | Anthracene 120-12-7 | C14H10 178.229 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D0219 | Antimony 7440-36-0 | Sb 121.760 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D1905 | Antimony acetate 3643-76-3 | C6H9O6Sb 298.890 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |