Browsing Toxins By Category
Displaying toxin 901 - 925 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2450 | alpha-Amanitin 23109-05-9 | C39H54N10O14S 918.970 g/mol |  |
| Amanitin has an unusually strong and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, preventing mRNA syn...more Number of Targets: 14 |
| T3D2537 | alpha-Bungarotoxin 11032-79-4 | Not Available 10285.030 g/mol |  |
| alpha-Bungarotoxin binds irreversibly and competitively to muscular and neuronal nicotinic acetylcholine receptors. This produces peripheral paralysis by blocking neur...more Number of Targets: 8 |
| T3D4050 | alpha-Chaconine 20562-03-2 | C45H73NO14 852.059 g/mol |  |
| Alpha-Chaconine has inhibitory effect on lung adenocarcinoma cell metastasis in vitro. Alpha-chaconine could inhibit phosphorylation of c-Jun N-terminal kinase (JNK) a...more Number of Targets: 0 |
| T3D2510 | alpha-Cobratoxin 769933-79-1 | Not Available 7830.960 g/mol |  |
| alpha-Cobratoxin is a muscle-type nicotinic acetylcholine receptor (nAChR) antagonist. It causes paralysis by preventing the binding of acetylcholine to the nAChR, as ...more Number of Targets: 6 |
| T3D2657 | alpha-Conotoxin (Conus geographus) Not Available | Not Available 1627.830 g/mol |  |
| alpha-Conotoxins act on postsynaptic membranes, where they inhibit nicotinic acetylcholine receptors in nerves and muscles. (L1107) Number of Targets: 15 |
| T3D4760 | Alpha-Cyclodextrin (Cyclohexa-Amylose) 10016-20-3 | C36H60O30 972.844 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D2610 | Alpha-hemolysin 94716-94-6 | Not Available 35904.070 g/mol |  |
| Alpha-hemolysin consists mainly of beta-sheets forms heptameric units on the cellular membrane, producing a complete beta-barrel pore. This pore allows the exchange of...more Number of Targets: 0 |
| T3D0115 | alpha-Hexachlorocyclohexane 319-84-6 | C6H6Cl6 290.830 g/mol |  |
| Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picro...more Number of Targets: 42 |
| T3D4940 | alpha-Ionone 127-41-3 | C13H20O 192.297 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4196 | Alpha-keto-delta-guanidinovaleric acid 3715-10-4 | C6H11N3O3 173.170 g/mol |  |
| Uremic toxins such as alpha-keto-delta-guanidinoacetic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels ...more Number of Targets: 3 |
| T3D4425 | Alpha-ketoisovaleric acid 759-05-7 | C5H8O3 116.115 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D2500 | alpha-Latrotoxin 65988-34-3 | Not Available 156855.500 g/mol |  |
| alpha-Latrotoxin acts presynaptically to release neurotransmitters from sensory and motor neurons, as well as on endocrine cells. alpha-Latrotoxin tetramers can form i...more Number of Targets: 10 |
| T3D4812 | Alpha-Linolenic Acid 463-40-1 | C18H30O2 278.430 g/mol |  |
| Alpha Linolenic Acid or ALA is considered an essential fatty acid because it is required for human health, but cannot be synthesized by humans. It is in fact a plant-...more Number of Targets: 12 |
| T3D2490 | alpha-Pompilidotoxin 202075-91-0 | Not Available 1530.850 g/mol |  |
| Pompilidotoxin slows down inactivation of neuronal, but not heart sodium channels, potentiating synaptic transmission. This is believed to be done by binding to the n...more Number of Targets: 10 |
| T3D3773 | alpha-Sarcin (Aspergillus giganteus) 86243-64-3 | Not Available 19724.200 g/mol |  |
| alpha-Sarcin is a highly specific ribotoxin that inhibits protein synthesis by cleaving a single phosphodiester bond in the sarcin/ricin loop (SRL) of the 23S−28S rRNA...more Number of Targets: 1 |
| T3D4042 | alpha-Solanine 20562-02-1 | C45H73NO15 868.059 g/mol |  |
| Solanum glycoalkaloids can inhibit cholinesterase, disrupt cell membranes, and be teratogenic (cause birth defects). One study suggests that the toxic mechanism of sol...more Number of Targets: 0 |
| T3D2700 | Alpha-Tocopherol 59-02-9 | C29H50O2 430.706 g/mol |  |
| Although all forms of Vitamin E exhibit antioxidant activity, it is known that the antioxidant activity of vitamin E is not sufficient to explain the vitamin's biologi...more Number of Targets: 11 |
| T3D2599 | Alpha-toxin (Clostridium perfringens) Not Available | Not Available 45529.285 g/mol |  |
| Clostridium perfringens alpha toxin is a zinc metallophospholipase requiring zinc for activation. The C-terminal C2-like PLAT domain binds calcium and allows the toxin...more Number of Targets: 1 |
| T3D4052 | alpha-Zearalenol 36455-72-8 | C18H24O5 320.380 g/mol |  |
| Mycotoxins, such as alpha-zearalenol (alpha-ZOL) and beta-zearalenol (beta-ZOL), as contaminants of animal food can impair fertility and can cause abnormal fetal devel...more Number of Targets: 0 |
| T3D2777 | Alprazolam 28981-97-7 | C17H13ClN4 308.765 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects muscle relaxation, anticonvulsant activity, motor ...more Number of Targets: 23 |
| T3D4726 | Alteplase 105857-23-6 | Not Available 62916.495 g/mol |  |
| Alteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen ...more Number of Targets: 4 |
| T3D3727 | Alternariol 641-38-3 | C14H10O5 258.226 g/mol |  |
| Alternariol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinest...more Number of Targets: 7 |
| T3D3728 | Alternariol methyl ether 23452-05-3 | C15H12O5 272.253 g/mol |  |
| Alternariol methyl ether has been shown to have genotoxic and mutagenic properties. It has demonstrated DNA-damaging activities such as single-strand and double-strand...more Number of Targets: 4 |
| T3D3729 | Altertoxin-1 56258-32-3 | C20H16O6 352.337 g/mol |  |
| Altertoxin-1 has been shown to have genotoxic and mutagenic properties. It has demonstrated DNA-damaging activities such as single-strand and double-strand DNA breaks,...more Number of Targets: 4 |
| T3D1490 | Aluminium acetoacetate 19022-77-6 | C12H21AlO9 336.271 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |