Browsing Toxins
Displaying toxin 2001 - 2025 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2468 | Prophalloin 67739-84-8 | C35H48N8O9S 756.869 g/mol |  |
| Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent sub...more Number of Targets: 6 |
| T3D2469 | Phalloin 28227-92-1 | C35H48N8O10S 772.868 g/mol |  |
| Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent sub...more Number of Targets: 6 |
| T3D2470 | Phallisin 19774-69-7 | C35H48N8O12S 804.867 g/mol |  |
| Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent sub...more Number of Targets: 6 |
| T3D2471 | Phallacidin 26645-35-2 | Not Available 2570.930 g/mol |  |
| Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent sub...more Number of Targets: 6 |
| T3D2472 | Phallacin 53568-40-4 | C37H50N8O12S 830.904 g/mol |  |
| Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent sub...more Number of Targets: 6 |
| T3D2473 | Phallisacin 58286-46-7 | C37H50N8O14S 862.903 g/mol |  |
| Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent sub...more Number of Targets: 6 |
| T3D2474 | Naftidrofuryl 31329-57-4 | C24H33NO3 383.524 g/mol |  |
| Naftidrofuryl blocks the type 2 serotonin (5-HT2) receptors and thereby inhibits the effects of serotonin-induced vasoconstriction
or platelet aggregation. It is also ...more Number of Targets: 3 |
| T3D2477 | Insulin 11061-68-0 | Not Available 11980.795 g/mol |  |
| Insulin has a direct inhibitory effect on the lipase concerned with the mobilization of fattty acids. Insulin binds to a receptor on the surface of the target cell and...more Number of Targets: 56 |
| T3D2478 | Levofloxacin 100986-85-4 | C18H20FN3O4 361.368 g/mol |  |
| Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyra...more Number of Targets: 3 |
| T3D2479 | Vindesine 53643-48-4 | C43H55N5O7 753.926 g/mol |  |
| Vindesine acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic funcitoning. The drug is cell-cycle specific for the S phase. Number of Targets: 1 |
| T3D2480 | Amitriptyline 50-48-6 | C20H23N 277.403 g/mol |  |
| Amitriptyline is metabolized to nortriptyline which inhibits the reuptake of norepinephrine and serotonin almost equally. Amitriptyline inhibits the membrane pump mech...more Number of Targets: 44 |
| T3D2481 | Ricin 9009-86-3 | Not Available 64089.975 g/mol |  |
| Pure ricin consists of a neutral A chain and an acidic B chain connected by S--S bonds. The A chain is capable of inhibiting protein synthesis which results in its tox...more Number of Targets: 1 |
| T3D2482 | Dapsone 80-08-0 | C12H12N2O2S 248.301 g/mol |  |
| Dapsone acts against bacteria and protozoa in the same way as sulphonamides, that is by inhibiting the synthesis of dihydrofolic acid through competition with para-ami...more Number of Targets: 3 |
| T3D2483 | Glipizide 29094-61-9 | C21H27N5O4S 445.535 g/mol |  |
| Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the...more Number of Targets: 3 |
| T3D2484 | Tetrodotoxin 4368-28-9 | C11H17N3O8 319.268 g/mol |  |
| Tetrodotoxin binds to what is known as site 1 of the fast voltage-gated sodium channel. Site 1 is located at the extracellular pore opening of the ion channel. The bin...more Number of Targets: 14 |
| T3D2486 | Methotrexate 59-05-2 | C20H22N8O5 454.439 g/mol |  |
| Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. ...more Number of Targets: 11 |
| T3D2487 | Apamin (Apis mellifera) 24345-16-2 | Not Available 5223.305 g/mol |  |
| Apamin binds to the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord and inhibits them, likely by acting as a pore blocker. Inhi...more Number of Targets: 3 |
| T3D2489 | Philanthotoxin 77108-00-0 | C23H41N5O3 435.603 g/mol |  |
| Philanthotoxins block glutamate receptors, especially the calcium permeable AMPA receptor and kainate receptor. (L1016) Number of Targets: 9 |
| T3D2490 | alpha-Pompilidotoxin 202075-91-0 | Not Available 1530.850 g/mol |  |
| Pompilidotoxin slows down inactivation of neuronal, but not heart sodium channels, potentiating synaptic transmission. This is believed to be done by binding to the n...more Number of Targets: 10 |
| T3D2491 | beta-Pompilidotoxin 216064-36-7 | Not Available 1558.860 g/mol |  |
| Pompilidotoxin slows down inactivation of neuronal, but not heart sodium channels, potentiating synaptic transmission. This is believed to be done by binding to the n...more Number of Targets: 10 |
| T3D2492 | Holocyclotoxin 88254-04-0 | Not Available 7834.125 g/mol |  |
| Holocyclotoxin produces paralysis by acting at the neuromuscular junction. (A2834) Number of Targets: 0 |
| T3D2493 | Poneratoxin 137084-94-7 | Not Available 2757.330 g/mol |  |
| Poneratoxin affects voltage-dependent sodium ion channels and is known to block nicotinic synaptic transmission in the insect central nervous system. (L1019) Number of Targets: 14 |
| T3D2494 | omega-Agatoxin 145017-83-0 | Not Available 12807.575 g/mol |  |
| omega-Agatoxins block the calcium channels in the presynaptic terminals of the neuromuscular junction in insects and vertebrates. This reduces calcium influx, resultin...more Number of Targets: 1 |
| T3D2495 | Atracotoxin, omega- (Hadronyche versuta) 193981-10-1 | Not Available 4055.410 g/mol |  |
| omega-Atracotoxins inhibit invertebrate voltage-gated calcium channel currents. (T170, L1812) Number of Targets: 0 |
| T3D2496 | Versutoxin 114264-83-4 | Not Available 4855.645 g/mol |  |
| Versutoxin inhibits both insect and mammalian voltage-gated sodium channels. It binds to site 3 in tetrodotoxin-sensitive sodium channels, which slows their inactivati...more Number of Targets: 14 |