Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0087 | 2,4-Dinitrophenol 51-28-5 | C6H4N2O5 184.106 g/mol |  |
| Acute 2,4-dinitrophenol poisoning (from ingestion) involves uncoupling of oxidative phosphorylation, which presumably reduces body's reservoirs of high-energy phosphat...more Number of Targets: 1 |
| T3D0088 | Bis(2-chloroethyl) ether 111-44-4 | C4H8Cl2O 143.012 g/mol |  |
| BCEE is extremely meabolized, with thiodiglycolic acid (TDGA) being the principal endproduct. The pathway leading to TDGA formation is uncertain, but probably involves...more Number of Targets: 38 |
| T3D0089 | Thiocyanate 302-04-5 | CNS 58.083 g/mol |  |
| Thiocyanate (sulphocyanate or SCN) is believed to be a goitrogenic compound. It is a competitive inhibitor of the human thyroid sodium/iodide symporter NIS. Thus, the ...more Number of Targets: 8 |
| T3D0091 | Chloride ion 22537-115-1 | Cl 35.454 g/mol |  |
| Chloride imbalances can lead to electrolyte and pH imbalances. Excessive chloride in the blood is known as hyperchloremia. Often hyperchloremia is associated with ex...more Number of Targets: 16 |
| T3D0092 | Cyclotrimethylenetrinitramine 121-82-4 | C3H6N6O6 222.116 g/mol |  |
| RDX can get into the lungs after breathing in the fumes of burning RDX or breathing in the dust from powdered RDX. It can also enter the body after ingestion of contam...more Number of Targets: 0 |
| T3D0093 | Hexachlorobenzene 118-74-1 | C6Cl6 284.782 g/mol |  |
| Hexachlorobenzene causes porphyria by modifying sulfhydryl groups in the catalytic or substrate-binding sites of uroporphyrinogen decarboxylase. This inhibits uroporph...more Number of Targets: 43 |
| T3D0094 | 2,4-Dinitrotoluene 121-14-2 | C7H6N2O4 182.134 g/mol |  |
| 2,4-DNT may cause conversion of oxyhemoglobin to methemoglobin via oxidation of iron(II) to iron(III) by its metabolites. High levels of methemoglobin are removed by c...more Number of Targets: 11 |
| T3D0096 | Ethion 563-12-2 | C9H22O4P2S4 384.476 g/mol |  |
| Ethion is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesterase...more Number of Targets: 10 |
| T3D0097 | 1,1,1-Trichloroethane 71-55-6 | C2H3Cl3 133.404 g/mol |  |
| 1,1,1-Trichloroethane is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acety...more Number of Targets: 41 |
| T3D0099 | Ethylbenzene 100-41-4 | C8H10 106.165 g/mol |  |
| Changes in the integrity of the cell membrane after partitioning of ethylbenzene into the lipid bilayer may subsequently affect the function of membrane, particularly ...more Number of Targets: 17 |
| T3D0100 | Radium-226 13982-63-3 | Ra 226.025 g/mol |  |
| Ionizing radiation produced by radium damages the DNA, resulting in gene mutations and chromosomal aberrations. This can both initiate and promote carcinogenesis, and ...more Number of Targets: 1 |
| T3D0101 | Thorium 7440-29-1 | Th 232.038 g/mol |  |
| The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal cha...more Number of Targets: 1 |
| T3D0102 | 4,6-Dinitro-o-cresol 534-52-1 | C7H6N2O5 198.133 g/mol |  |
| 4,6-Dinitro-o-cresol is an uncoupler of oxidative phosphorylation. It is believed to cause an acceleration of metabolic processes that are part of the tricarboxylic ac...more Number of Targets: 4 |
| T3D0103 | 1,3,5-Trinitrobenzene 99-35-4 | C6H3N3O6 213.105 g/mol |  |
| In the red blood cell, 1,3,5-TNB induces formation of methemoglobin, leading to cyanosis. Reduction of the nitrogroup(s) of 1,3,5-TNB produces reactive nitroaromatic r...more Number of Targets: 0 |
| T3D0104 | Chlorobenzene 108-90-7 | C6H5Cl 112.557 g/mol |  |
| The reactive metabolites of chlorobenzene are believed to bind both liver and kidney proteins, causing direct damage. Chlorobenzene also activates nuclear factor-kappa...more Number of Targets: 38 |
| T3D0105 | Radon 10043-92-2 | Rn 222.000 g/mol |  |
| The ionizing radiation produced by radon causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal chang...more Number of Targets: 1 |
| T3D0106 | Radium-228 15262-20-1 | Ra 228.031 g/mol |  |
| Ionizing radiation produced by radium damages the DNA, resulting in gene mutations and chromosomal aberrations. This can both initiate and promote carcinogenesis, and ...more Number of Targets: 1 |
| T3D0107 | Thorium-230 14269-63-7 | Th 230.033 g/mol |  |
| The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal cha...more Number of Targets: 1 |
| T3D0108 | Uranium-235 15117-96-1 | U 235.044 g/mol |  |
| Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot...more Number of Targets: 1 |
| T3D0109 | Barium 7440-39-3 | Ba 137.326 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 22 |
| T3D0110 | Fluoranthene 206-44-0 | C16H10 202.251 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 6 |
| T3D0111 | Uranium-234 13966-29-5 | U 234.041 g/mol |  |
| Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot...more Number of Targets: 1 |
| T3D0112 | n-Nitrosodi-n-propylamine 621-64-7 | C6H14N2O 130.188 g/mol |  |
| Reactive metabolites of n-nitrosodi-n-propylamine are believed to form adducts with DNA, resulting in carcinogenic effects. (L216) Number of Targets: 1 |
| T3D0113 | Thorium-228 14274-82-9 | Th 228.029 g/mol |  |
| The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal cha...more Number of Targets: 1 |
| T3D0114 | Radon-222 14859-67-7 | Rn 222.018 g/mol |  |
| The ionizing radiation produced by radon causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal chang...more Number of Targets: 1 |