Browsing Toxins
Displaying toxin 3026 - 3050 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4026 | (+)-Calycanthine 595-05-1 | C22H26N4 346.469 g/mol |  |
| The principal alkaloid of the family Calycanthaceae, calycanthine has long been recognized as a central convulsant. Convulsant actions of calycanthine is mediated, at ...more Number of Targets: 0 |
| T3D4027 | (S)-Isocorydine 475-67-2 | C20H23NO4 341.401 g/mol |  |
| Isocorydine induces G2/M phase arrest by increasing cyclin B1 and p-CDK1 expression levels, which was caused by decreasing the expression and inhibiting the activation...more Number of Targets: 1 |
| T3D4028 | (S)-2-Propylpiperidine 458-88-8 | C8H17N 127.227 g/mol |  |
| (S)-2-Propylpiperidine is a neurotoxin which disrupts the peripheral nervous system. It is toxic to humans and all classes of livestock; less than 0.2g is fatal to hum...more Number of Targets: 0 |
| T3D4029 | Okadaic acid 78111-17-8 | C44H68O13 805.003 g/mol |  |
| Okadaic acid (OA) dramatically increases both nerve growth factor (NGF) mRNA content (50-fold) and NGF secretion (100-fold) in astrocytes. Okadaic acid also activated ...more Number of Targets: 1 |
| T3D4030 | Dinophysistoxin 1 81720-10-7 | C45H70O13 819.030 g/mol |  |
| Dinophysistoxin 1 (DTX1) is the analogue of okadaic acid causing diarrheic shellfish poisoning (DSP) in humans shortly after the ingestion of contaminated seafood. DTX...more Number of Targets: 0 |
| T3D4032 | Cyclochlorotine 12663-46-6 | C24H31Cl2N5O7 572.438 g/mol |  |
| Cyclochlorotine (CC) causes hepatic necrosis and has carcinogenic properties. The in vitro application of CC on myocytes induced disruption of myofibrils and large acc...more Number of Targets: 0 |
| T3D4038 | Gonyautoxin I 60748-39-2 | C10H17N7O9S 411.348 g/mol |  |
| The gonyautoxin toxicity is caused by the reversibly binding to its receptor site on the voltage-gated sodium channel on excitable cells, thus blocking the influx of N...more Number of Targets: 0 |
| T3D4039 | Gonyautoxin II 60508-89-6 | C10H17N7O8S 395.349 g/mol |  |
| The gonyautoxin toxicity is caused by the reversibly binding to its receptor site on the voltage-gated sodium channel on excitable cells, thus blocking the influx of N...more Number of Targets: 0 |
| T3D4040 | Domoic acid 14277-97-5 | C15H21NO6 311.330 g/mol |  |
| Domoic acid acts as a neurotoxin. It induces excitotoxicity by an integrative action on ionotropic glutamate receptors at both sides of the synapse for which it has hi...more Number of Targets: 1 |
| T3D4042 | alpha-Solanine 20562-02-1 | C45H73NO15 868.059 g/mol |  |
| Solanum glycoalkaloids can inhibit cholinesterase, disrupt cell membranes, and be teratogenic (cause birth defects). One study suggests that the toxic mechanism of sol...more Number of Targets: 0 |
| T3D4050 | alpha-Chaconine 20562-03-2 | C45H73NO14 852.059 g/mol |  |
| Alpha-Chaconine has inhibitory effect on lung adenocarcinoma cell metastasis in vitro. Alpha-chaconine could inhibit phosphorylation of c-Jun N-terminal kinase (JNK) a...more Number of Targets: 0 |
| T3D4051 | Gymnodimine 173792-58-0 | C32H45NO4 507.704 g/mol |  |
| Gymnodimine exerts its toxic effects via binding to nicotinic acetylcholine receptors with picomolar affinities with no sign of apparent reversibility in short time fr...more Number of Targets: 0 |
| T3D4052 | alpha-Zearalenol 36455-72-8 | C18H24O5 320.380 g/mol |  |
| Mycotoxins, such as alpha-zearalenol (alpha-ZOL) and beta-zearalenol (beta-ZOL), as contaminants of animal food can impair fertility and can cause abnormal fetal devel...more Number of Targets: 0 |
| T3D4053 | beta-Zearalenol 71030-11-0 | C18H24O5 320.380 g/mol |  |
| Mycotoxins, such as alpha-zearalenol (alpha-ZOL) and beta-zearalenol (beta-ZOL), as contaminants of animal food can impair fertility and can cause abnormal fetal devel...more Number of Targets: 1 |
| T3D4056 | Debromoaplysiatoxin 52423-28-6 | C32H48O10 592.718 g/mol |  |
| Debromoaplysiatoxin have the ability to evoke biological and biochemical responses in cells, and belong to the TPA (12-O-tetradecanoylphorbol 13-acetate) type tumor pr...more Number of Targets: 0 |
| T3D4059 | Senecionine 130-01-8 | C18H25NO5 335.395 g/mol |  |
| Senecionine is classified as a pyrrolizidine alkaloid (PA). Unsaturated pyrrolizidine alkaloids are hepatotoxic, that is, damaging to the liver. PAs also cause hepatic...more Number of Targets: 0 |
| T3D4060 | Retronecine 480-85-3 | C8H13NO2 155.194 g/mol |  |
| Retronecine is classified as a pyrrolizidine alkaloid (PA). Unsaturated pyrrolizidine alkaloids are hepatotoxic, that is, damaging to the liver. PAs also cause hepatic...more Number of Targets: 0 |
| T3D4061 | Veratridine 71-62-5 | C36H51NO11 673.790 g/mol |  |
| Veratridine is a steroid-derived alkaloid from plants in the Liliaceae family that functions as a neurotoxin by abolishing inactivation of sodium ion channels. It bind...more Number of Targets: 0 |
| T3D4063 | Ranunculin 644-69-9 | C11H16O8 276.240 g/mol |  |
| Ranunculin (RAN) inhibited the incorporation of 3H-labeled precursors into DNA and RNA of L1210 cells. RAN (15 mumol/L) markedly decreased DNA synthesis catalyzed by D...more Number of Targets: 0 |
| T3D4064 | Lycorine 476-28-8 | C16H17NO4 287.311 g/mol |  |
| Lycorine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 1 |
| T3D4065 | Mesaconitine 2752-64-9 | C33H45NO11 631.711 g/mol |  |
| Mesaconitine (MA) is one of the Aconitum sp. alkaloids. The primary toxicity of Aconitum sp. alkaloids is on the heart and the central nervous system. They can induce ...more Number of Targets: 0 |
| T3D4066 | Ryanodine 15662-33-6 | C25H35NO9 493.547 g/mol |  |
| Ryanodine has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells....more Number of Targets: 1 |
| T3D4067 | Convallatoxin 508-75-8 | C29H42O10 550.638 g/mol |  |
| Convallatoxin (CNT) is classified as a cardiac glycoside. Cardiac glycosides are well known Na+/K+-ATPase inhibitors, and some of them are used to treat congestive hea...more Number of Targets: 0 |
| T3D4068 | C-Curarine 7168-64-1 | C40H44N4O 596.803 g/mol |  |
| It has been prpoposed that surarine speeds up destruction of chemical transmitter, and raises the threshold point at which excess of the transmitter is able to exert i...more Number of Targets: 0 |
| T3D4069 | Phorbol 17673-25-5 | C20H28O6 364.433 g/mol |  |
| The term 'phorbol' is used to describe the family of naturally occurring compounds that can be referred to as tigliane diterpenes. Phorbol esters are the tetracyclic d...more Number of Targets: 0 |