Browsing Toxins By Category
Displaying toxin 2126 - 2150 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4051 | Gymnodimine 173792-58-0 | C32H45NO4 507.704 g/mol |  |
| Gymnodimine exerts its toxic effects via binding to nicotinic acetylcholine receptors with picomolar affinities with no sign of apparent reversibility in short time fr...more Number of Targets: 0 |
| T3D2453 | Gyromitrin 16568-02-8 | C4H8N2O 100.119 g/mol |  |
| The toxicity is caused by the conversion of the hydrazine (gyromitrin) to a hydrazine metabolite intermediate monomethylhydrazine. This occurs when gyromitrin begins t...more Number of Targets: 0 |
| T3D2893 | Halazepam 23092-17-3 | C17H12ClF3N2O 352.738 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity...more Number of Targets: 18 |
| T3D2576 | Haloperidol 52-86-8 | C21H23ClFNO2 375.864 g/mol |  |
| The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, but the drug appears to depress the CNS at the subcortical level of the...more Number of Targets: 26 |
| T3D3856 | Halosulfuron-methyl 100784-20-1 | C13H15ClN6O7S 434.812 g/mol |  |
| Not Available Number of Targets: 8 |
| T3D3001 | Halothane 151-67-7 | C2HBrClF3 197.382 g/mol |  |
| Halothane causes general anaethesia due to its actions on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility. Its imm...more Number of Targets: 22 |
| T3D4565 | Haloxazolam 59128-97-1 | C17H14BrFN2O2 377.208 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity...more Number of Targets: 18 |
| T3D2629 | Hanatoxin 170780-01-5 | Not Available 4120.690 g/mol |  |
| Hanatoxin inhibits voltage-gated potassium channels by altering the gating energetics, which it does by occupying multiple binding sites on the channel. It can also in...more Number of Targets: 3 |
| T3D4372 | Hawkinsin 63224-90-8 | C11H17NO6S 291.321 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D2600 | Heat-labile enterotoxin (Escherichia coli) Not Available | Not Available 35330.140 g/mol |  |
| Through ADP-ribosylation of a G-protein, heat-labile enterotoxin stimulates adenylate cyclase leading to increased cAMP in epithelial cells. Elevated cAMP levels stimu...more Number of Targets: 2 |
| T3D2566 | Heparin 9005-49-6 | C26H41NO34S4 1039.850 g/mol |  |
| Heparin-induced thrombocytopenia (HIT) is caused by the formation of abnormal antibodies that activate platelets. Heparin occurs naturally in the human body, but the d...more Number of Targets: 14 |
| T3D1949 | Heptabromobiphenyl 35194-78-6 | C12H3Br7 706.480 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D2042 | Heptabromobiphenyl Ether 68928-80-3 | C12H3Br7O 722.480 g/mol |  |
| Like other halogenated aromatic hydrocarbons, polybrominated diphenyl ethers bind to the cellular aryl hydrocarbon receptor (AhR), which regulates the synthesis of a v...more Number of Targets: 6 |
| T3D0034 | Heptachlor 76-44-8 | C10H5Cl7 373.318 g/mol |  |
| Heptachlor is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overstimulati...more Number of Targets: 40 |
| T3D0046 | Heptachlor epoxide 1024-57-3 | C10H5Cl7O 389.317 g/mol |  |
| Heptachlor epoxide is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overs...more Number of Targets: 41 |
| T3D4188 | Heptanal 111-71-7 | C7H14O 114.186 g/mol |  |
| Uremic toxins such as heptanal are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulat...more Number of Targets: 5 |
| T3D4597 | Heptanoic acid 111-14-8 | C7H14O2 130.185 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4887 | Heptyl 4-hydroxybenzoate 1085-12-7 | C14H20O3 236.307 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D0821 | Heratomin 61265-06-3 | C16H14O4 270.280 g/mol |  |
| The mechanism of action many furocoumarins is based on their ability to form photoadducts with DNA and other cellular components such as RNA, proteins, and several pro...more Number of Targets: 3 |
| T3D4562 | Heroin 561-27-3 | C21H23NO5 369.411 g/mol |  |
| Heroin is a mu-opioid agonist. It acts on endogenous mu-opioid receptors that are spread in discrete packets throughout the brain, spinal cord and gut in almost all ma...more Number of Targets: 4 |
| T3D2505 | Heteropodatoxin 189120-72-7 | Not Available 3917.380 g/mol |  |
| Heteropodatoxin blocks A-type, transient voltage-gated potassium channels by acting as a gating modifier. As a result, a larger depolarization is needed to open the ch...more Number of Targets: 3 |
| T3D2631 | Heteroscodratoxin Not Available | Not Available 4003.400 g/mol |  |
| Heteroscodratoxin inhibits voltage-gated potassium channels by binding to the extracellular linker of the channel and shifting activation of the channel to more depola...more Number of Targets: 5 |
| T3D2041 | Hexabromobiphenyl Ether 36483-60-0 | C12H4Br6O 643.584 g/mol |  |
| Like other halogenated aromatic hydrocarbons, polybrominated diphenyl ethers bind to the cellular aryl hydrocarbon receptor (AhR), which regulates the synthesis of a v...more Number of Targets: 6 |
| T3D1800 | Hexabromocyclododecane 25637-99-4 | C12H18Br6 641.695 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 3 |
| T3D0093 | Hexachlorobenzene 118-74-1 | C6Cl6 284.782 g/mol |  |
| Hexachlorobenzene causes porphyria by modifying sulfhydryl groups in the catalytic or substrate-binding sites of uroporphyrinogen decarboxylase. This inhibits uroporph...more Number of Targets: 43 |