Browsing Toxins By Category
Displaying toxin 3226 - 3250 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4166 | Spermine 71-44-3 | C10H26N4 202.340 g/mol |  |
| Uremic toxins such as spermine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulat...more Number of Targets: 21 |
| T3D2630 | Sphingomyelinase D (Loxosceles intermedia) 9031-54-3 | Not Available 34158.125 g/mol |  |
| Sphingomyelinase D catalyzes the hydrolysis of sphingomyelin, inducing complement-dependent haemolysis, dermonecrosis, blood vessel permeability and platelet aggregati...more Number of Targets: 0 |
| T3D0819 | Sphondin 483-66-9 | C12H8O4 216.190 g/mol |  |
| Sphondin possesses an inhibitory effect on IL-1b-induced COX-2 protein expression and PGE2 release in human pulmonary epithelial cell line (A549). The mechanism of act...more Number of Targets: 3 |
| T3D4536 | Spirodiclofen 148477-71-8 | C21H24Cl2O4 411.319 g/mol |  |
| Not Available Number of Targets: 19 |
| T3D4753 | Spironolactone 52-01-7 | C24H32O4S 416.573 g/mol |  |
| Spironolactone is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-pot...more Number of Targets: 15 |
| T3D3923 | Spiroxamine 118134-30-8 | C18H35NO2 297.476 g/mol |  |
| Not Available Number of Targets: 20 |
| T3D3776 | Sporidesmin 1456-55-9 | C18H20ClN3O6S2 473.951 g/mol |  |
| Sporidesmin and its reduced (dithiol) form undergo cyclic reduction/autoxidation reactions with glutathione and other thiols, generating toxic superoxide radicals, hyd...more Number of Targets: 0 |
| T3D1265 | Stannane 2406-52-2 | H4Sn 122.740 g/mol |  |
| Inorganic and organic tin compounds are weak inhibitors of alcohol dehydrogenase. (A183) Number of Targets: 7 |
| T3D4772 | Stavudine 3056-17-5 | C10H12N2O4 224.213 g/mol |  |
| Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Number of Targets: 1 |
| T3D4755 | Stearic acid 57-11-4 | C18H36O2 284.477 g/mol |  |
| Not Available Number of Targets: 7 |
| T3D3663 | Sterigmatocystin 10048-13-2 | C18H12O6 324.284 g/mol |  |
| Sterigmatocystin's carcinogenic properties are a result of its ability to form guanyl DNA adducts and bind to DNA. In addition, DNA adduct formation causes enhanced pr...more Number of Targets: 3 |
| T3D0877 | Stibine 7803-52-3 | H3Sb 124.780 g/mol |  |
| The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes ...more Number of Targets: 20 |
| T3D2552 | Sticholysin 269658-04-0; 183449-91-4 | Not Available 19390.885 g/mol |  |
| Sticholysin is a cardiac stimulatory and hemolytic pore-forming protein. Pore formation likely proceeds by membrane binding via a surface rich in aromatic residues, fo...more Number of Targets: 0 |
| T3D2647 | Stonustoxin Not Available | Not Available 79523.640 g/mol |  |
| Stonustoxin induces hemolytic activities due to its ability to form pores in the cell membrane. It is also myotoxic and interferes irreversibly with neuromuscular func...more Number of Targets: 0 |
| T3D4727 | Streptokinase 9002-01-1 | Not Available 50139.695 g/mol |  |
| Plasminogen is an inactive molecule that becomes activated to plasmin when the Arg/Val bond is cleaved. Plasmin breaks down fibrin clots created by the blood clotting ...more Number of Targets: 2 |
| T3D2622 | Streptolysin O (Streptococcus pyogenes) 98072-47-0 | Not Available 63637.990 g/mol |  |
| Streptolysin O binds to cholesterol on eukaryotic cell membranes, then is able to lyse them. (T170) Number of Targets: 1 |
| T3D2788 | Streptozocin 18883-66-4 | C8H15N3O7 265.221 g/mol |  |
| Streptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas. It is used in medical research to prod...more Number of Targets: 3 |
| T3D2502 | Stromatoxin 1262235-00-6 | Not Available 3798.295 g/mol | |
| Stromatoxin blocks the delayed-rectifier type potassium channels Kv2.1, Kv2.2, Kv2.1/9.3 and the A-type potassium channel Kv4.2, with affinity (IC50) of 12.7 nM, 21.4 ...more Number of Targets: 4 |
| T3D1540 | Strontium aluminate 12004-37-4 | Al2O5Sr2 309.200 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D1317 | Strontium arsenite tetrahydrate 10378-48-0 | As2H8O8Sr 373.520 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D1719 | Strontium bromate 14519-18-7 | BrO3Sr 215.520 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D1756 | Strontium bromide 10476-81-0 | Br2Sr 247.430 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D0712 | Strontium chromate 7789-06-2 | CrO4Sr 203.610 g/mol |  |
| Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more Number of Targets: 5 |
| T3D3575 | Strontium nitrate 10042-76-9 | N2O6Sr 211.630 g/mol |  |
| Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and met...more Number of Targets: 9 |
| T3D0120 | Strontium-90 10098-97-2 | Sr 89.908 g/mol |  |
| The fact that strontium is chemically similar to calcium allows it to exchange for calcium in bone. It affects bone development and strength by binding directly to hyd...more Number of Targets: 1 |