Browsing Toxins
Displaying toxin 2401 - 2425 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2989 | Chlorpheniramine 132-22-9 | C16H19ClN2 274.788 g/mol |  |
| Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative sympt...more Number of Targets: 13 |
| T3D2990 | Phenacemide 63-98-9 | C9H10N2O2 178.188 g/mol |  |
| Phenacemide binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronizat...more Number of Targets: 1 |
| T3D2991 | Ambenonium 7648-98-8 | C28H42Cl2N4O2 537.564 g/mol |  |
| Ambenonium is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 1 |
| T3D2992 | Econazole 27220-47-9 | C18H15Cl3N2O 381.684 g/mol |  |
| Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fung...more Number of Targets: 4 |
| T3D2993 | Doxepin 1668-19-5 | C19H21NO 279.376 g/mol |  |
| The mechanism of action of doxepin is not completely understood. It is thought that like amitriptyline, doxepin enhances the actions of norepinephrine and serotonin by...more Number of Targets: 23 |
| T3D2995 | Nefazodone 83366-66-9 | C25H32ClN5O2 470.007 g/mol |  |
| Within the serotonergic system, nefazodone acts as an antagonist at type 2 serotonin (5-HT2) post-synaptic receptors and, like fluoxetine-type antidepressants, inhibit...more Number of Targets: 14 |
| T3D2996 | Desipramine 50-47-5 | C18H22N2 266.381 g/mol |  |
| Desipramine is a tricyclic antidepressant (TCA) that selectively blocks reuptake of norepinephrine (noradrenaline) from the neuronal synapse. It also inhibits serotoni...more Number of Targets: 25 |
| T3D2997 | Sertaconazole 99592-32-2 | C20H15Cl3N2OS 437.770 g/mol |  |
| Sertaconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the ...more Number of Targets: 0 |
| T3D2999 | Bupropion 34841-39-9 | C13H18ClNO 239.741 g/mol |  |
| Bupropion selectively inhibits the neuronal reuptake of dopamine, norepinephrine, and serotonin; actions on dopaminergic systems are more significant than imipramine o...more Number of Targets: 14 |
| T3D3000 | Trimetrexate 52128-35-5 | C19H23N5O3 369.418 g/mol |  |
| In vitro studies have shown that trimetrexate is a competitive inhibitor of dihydrofolate reductase (DHFR) from bacterial, protozoan, and mammalian sources. DHFR catal...more Number of Targets: 2 |
| T3D3001 | Halothane 151-67-7 | C2HBrClF3 197.382 g/mol |  |
| Halothane causes general anaethesia due to its actions on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility. Its imm...more Number of Targets: 22 |
| T3D3003 | Chloroprocaine 133-16-4 | C13H19ClN2O2 270.755 g/mol |  |
| Chloroprocaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sod...more Number of Targets: 5 |
| T3D3004 | Moclobemide 71320-77-9 | C13H17ClN2O2 268.739 g/mol |  |
| The mechanism of action of moclobemide involves the selective, reversible inhibition of MAO-A. This inhibition leads to a decrease in the metabolism and destruction of...more Number of Targets: 1 |
| T3D3005 | Orphenadrine 83-98-7 | C18H23NO 269.381 g/mol |  |
| Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkine...more Number of Targets: 16 |
| T3D3006 | Phenobarbital 50-06-6 | C12H12N2O3 232.235 g/mol |  |
| Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity f...more Number of Targets: 9 |
| T3D3007 | Escitalopram 128196-01-0 | C20H21FN2O 324.392 g/mol |  |
| The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. ...more Number of Targets: 6 |
| T3D3009 | Chlormezanone 80-77-3 | C11H12ClNO3S 273.736 g/mol |  |
| Chlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmit...more Number of Targets: 1 |
| T3D3010 | Fluoxymesterone 76-43-7 | C20H29FO3 336.441 g/mol |  |
| Fluoxymesterone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic...more Number of Targets: 5 |
| T3D3011 | Pergolide 66104-22-1 | C19H26N2S 314.488 g/mol |  |
| The dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi proteins. In lactotrophs, stimulation of dopamine D2 receptor causes inhibi...more Number of Targets: 17 |
| T3D3012 | Ciclopirox 29342-05-0 | C12H17NO2 207.269 g/mol |  |
| Unlike antifungals such as itraconazole and terbinafine, which affect sterol synthesis, ciclopirox is thought to act through the chelation of polyvalent metal cations,...more Number of Targets: 5 |
| T3D3013 | Desflurane 57041-67-5 | C3H2F6O 168.038 g/mol |  |
| Desflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Desflurane...more Number of Targets: 8 |
| T3D3014 | Dexfenfluramine 3239-44-9 | C12H16F3N 231.257 g/mol |  |
| Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor...more Number of Targets: 4 |
| T3D3015 | Oxymorphone 76-41-5 | C17H19NO4 301.337 g/mol |  |
| Oxymorphone interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the poste...more Number of Targets: 3 |
| T3D3016 | Zopiclone 43200-80-2 | C17H17ClN6O3 388.808 g/mol |  |
| Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. Both zopic...more Number of Targets: 5 |
| T3D3017 | Bromocriptine 25614-03-3 | C32H40BrN5O5 654.595 g/mol |  |
| The dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi proteins. In lactotrophs, stimulation of dopamine D2 receptor causes inhibi...more Number of Targets: 25 |