Displaying toxin 2351 - 2375 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D2928Zonisamide
68291-97-4
C8H8N2O3S
212.226 g/mol
Thumb
  • Amide
  • Anticonvulsant
  • Antioxidant
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Zonisamide binds to sodium channels and voltage sensitive calcium channels, which suppresses neuronal depolarization and hypersynchronization. Zonisamide also inhibits...more
Number of Targets: 31
T3D2929Anileridine
144-14-9
C22H28N2O2
352.470 g/mol
Thumb
  • Amine
  • Analgesic
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Narcotic
  • Opiate Agonist
  • Organic Compound
  • Synthetic Compound
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more
Number of Targets: 1
T3D2931Almotriptan
181183-52-8
C17H25N3O2S
335.464 g/mol
Thumb
  • Amide
  • Amine
  • Anti-Inflammatory Agent
  • Anti-Migraine Agent
  • Drug
  • Metabolite
  • Organic Compound
  • Selective Serotonin Agonist
  • Serotonin Agonist
  • Serotonin Antagonist
  • Serotonin Receptor Agonist
  • Synthetic Compound
  • Vasoconstrictor Agent
Almotriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blood vessel constriction.
Number of Targets: 2
T3D2932Buprenorphine
52485-79-7
C29H41NO4
467.640 g/mol
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  • Amine
  • Analgesic, Opioid
  • Drug
  • Ether
  • Metabolite
  • Narcotic
  • Narcotic Antagonist
  • Organic Compound
  • Synthetic Compound
Buprenorphine's analgesic effect is due to partial agonist activity at mu-opioid receptors. Buprenorphine is also a kappa-opioid receptor antagonist. The partial agoni...more
Number of Targets: 4
T3D2933Mesoridazine
5588-33-0
C21H26N2OS2
386.574 g/mol
Thumb
  • Amine
  • Antipsychotic Agent
  • Dopamine Antagonist
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Phenothiazine
  • Synthetic Compound
Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is re...more
Number of Targets: 14
T3D2934Maprotiline
10262-69-8
C20H23N
277.403 g/mol
Thumb
  • Adrenergic Uptake Inhibitor
  • Amine
  • Antidepressant
  • Antidepressant, Second-Generation
  • Antidepressive Agent
  • Antidepressive Agent, Second-Generation
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Maprotiline exerts its antidepressant action by inhibition of presynaptic uptake of catecholamines, thereby increasing their concentration at the synaptic clefts of th...more
Number of Targets: 17
T3D2935Diethylpropion
90-84-6
C13H19NO
205.296 g/mol
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  • Amine
  • Anorexigenic Agent
  • Appetite Depressant
  • Drug
  • Ester
  • Metabolite
  • Organic Compound
  • Stimulant
  • Synthetic Compound
Diethylpropion is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these i...more
Number of Targets: 2
T3D2936Aspirin
50-78-2
C9H8O4
180.157 g/mol
Thumb
  • Anti-Inflammatory Agent, Non-Steroidal
  • Anticoagulant
  • Antipyretic
  • Cyclooxygenase Inhibitor
  • Drug
  • Ester
  • Fibrinolytic Agent
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Platelet Aggregation Inhibitor
  • Salicylate
  • Synthetic Compound
The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to actions by both the acetyl and the salicylate portions of the intact molec...more
Number of Targets: 18
T3D2937Felbamate
25451-15-4
C11H14N2O4
238.240 g/mol
Thumb
  • Amine
  • Anticonvulsant
  • Antiepileptic Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Neuroprotective Agent
  • Organic Compound
  • Synthetic Compound
The mechanism by which felbamate exerts its anticonvulsant activity is unknown, but in animal test systems designed to detect anticonvulsant activity, felbamate has pr...more
Number of Targets: 3
T3D2938Fexofenadine
83799-24-0
C32H39NO4
501.656 g/mol
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  • Amine
  • Anti-Allergic Agent
  • Drug
  • Food Toxin
  • Histamine Antagonist
  • Histamine H1 Antagonist, Non-Sedating
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This b...more
Number of Targets: 3
T3D2939Naratriptan
121679-13-8
C17H25N3O2S
335.464 g/mol
Thumb
  • Amide
  • Amine
  • Drug
  • Metabolite
  • Organic Compound
  • Selective Serotonin Agonist
  • Serotonin Agonist
  • Serotonin Antagonist
  • Serotonin Receptor Agonist
  • Synthetic Compound
  • Vasoconstrictor Agent
Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT1D receptors, which serves t...more
Number of Targets: 4
T3D2940Rizatriptan
145202-66-0
C15H19N5
269.345 g/mol
Thumb
  • Amine
  • Anti-Inflammatory Agent
  • Anti-Migraine Agent
  • Drug
  • Metabolite
  • Organic Compound
  • Selective Serotonin Agonist
  • Serotonin Agonist
  • Serotonin Antagonist
  • Serotonin Receptor Agonist
  • Synthetic Compound
  • Vasoconstrictor Agent
Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT1D receptors, which serves t...more
Number of Targets: 7
T3D2941Hydrocodone
125-29-1
C18H21NO3
299.364 g/mol
Thumb
  • Amine
  • Analgesic
  • Analgesic, Opioid
  • Antitussive Agent
  • Drug
  • Ether
  • Metabolite
  • Narcotic
  • Organic Compound
  • Synthetic Compound
Hydrocodone acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Hydrocodone primarily affects OP3 receptors, which ar...more
Number of Targets: 3
T3D2942Mepivacaine
96-88-8
C15H22N2O
246.348 g/mol
Thumb
  • Amide
  • Amine
  • Anesthetic, Local
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing ...more
Number of Targets: 1
T3D2951Neomycin
1404-04-2
C23H46N6O13
614.644 g/mol
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  • Amine
  • Aminoglycoside
  • Anti-Bacterial Agent
  • Antibiotic
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Aminoglycosides like neomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically neomycin binds to four nucleotides of 16S rRNA and a sing...more
Number of Targets: 3
T3D2952Gabapentin
60142-96-3
C9H17NO2
171.237 g/mol
Thumb
  • Amine
  • Analgesic
  • Anti-Anxiety Agent
  • Anticonvulsant
  • Antimanic Agent
  • Antiparkinson Agent
  • Calcium Channel Blocker
  • Drug
  • Excitatory Amino Acid Antagonist
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhanc...more
Number of Targets: 7
T3D2953Doxorubicin
23214-92-8
C27H29NO11
543.519 g/mol
Thumb
  • Amine
  • Antibiotic
  • Antibiotic, Antineoplastic
  • Antineoplastic Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between bas...more
Number of Targets: 14
T3D2954Frovatriptan
158747-02-5
C14H17N3O
243.304 g/mol
Thumb
  • Amide
  • Amine
  • Anti-Inflammatory Agent
  • Anti-Migraine Agent
  • Drug
  • Ester
  • Metabolite
  • Organic Compound
  • Serotonin Agonist
  • Serotonin Receptor Agonist
  • Synthetic Compound
  • Vasoconstrictor Agent
Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT1D receptors, which serves t...more
Number of Targets: 2
T3D2955Levobupivacaine
27262-47-1
C18H28N2O
288.428 g/mol
Thumb
  • Amide
  • Amine
  • Anesthetic
  • Anesthetic, Local
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Levobupivacaine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholi...more
Number of Targets: 1
T3D2956Tioconazole
65899-73-2
C16H13Cl3N2OS
387.711 g/mol
Thumb
  • 14-alpha Demethylase Inhibitor
  • Amine
  • Antifungal Agent
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Tioconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this wa...more
Number of Targets: 2
T3D2957Balsalazide
80573-04-2
C17H15N3O6
357.318 g/mol
Thumb
  • Amide
  • Amine
  • Anti-Inflammatory Agent, Non-Steroidal
  • Anti-Ulcer Agent
  • Drug
  • Ester
  • Gastrointestinal Agent
  • Metabolite
  • Organic Compound
  • Synthetic Compound
The mechanism of action of 5-aminosalicylic acid is unknown, but appears exert its anti-inflammatory effects locally (in the GI tract) rather than systemically. Mucosa...more
Number of Targets: 4
T3D2958Bethanechol
674-38-4
C7H17N2O2
161.222 g/mol
Thumb
  • Amine
  • Carbamate
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Muscarinic Agonist
  • Organic Compound
  • Parasympathomimetic
  • Synthetic Compound
Bethanechol directly stimulates cholinergic receptors in the parasympathetic nervous system while stimulating the ganglia to a lesser extent. Its effects are predomina...more
Number of Targets: 4
T3D2959Phytonadione
84-80-0
C31H46O2
450.696 g/mol
Thumb
  • Antifibrinolytic Agent
  • Drug
  • Ester
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Synthetic Compound
  • Vitamin
  • Vitamin K
Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hep...more
Number of Targets: 2
T3D2960Mycophenolic acid
24280-93-1
C17H20O6
320.337 g/mol
Thumb
  • Antibiotic, Antineoplastic
  • Drug
  • Enzyme Inhibitor
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Mycophenolic acid is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pa...more
Number of Targets: 5
T3D2961Ketoconazole
65277-42-1
C26H28Cl2N4O4
531.431 g/mol
Thumb
  • 14-alpha Demethylase Inhibitor
  • Amide
  • Amine
  • Antifungal Agent
  • Cosmetic Toxin
  • Drug
  • Ether
  • Food Toxin
  • Household Toxin
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergoste...more
Number of Targets: 26
Displaying toxin 2351 - 2375 of 3678 in total