Browsing Toxins
Displaying toxin 2351 - 2375 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2928 | Zonisamide 68291-97-4 | C8H8N2O3S 212.226 g/mol |  |
| Zonisamide binds to sodium channels and voltage sensitive calcium channels, which suppresses neuronal depolarization and hypersynchronization. Zonisamide also inhibits...more Number of Targets: 31 |
| T3D2929 | Anileridine 144-14-9 | C22H28N2O2 352.470 g/mol |  |
| Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more Number of Targets: 1 |
| T3D2931 | Almotriptan 181183-52-8 | C17H25N3O2S 335.464 g/mol |  |
| Almotriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blood vessel constriction. Number of Targets: 2 |
| T3D2932 | Buprenorphine 52485-79-7 | C29H41NO4 467.640 g/mol |  |
| Buprenorphine's analgesic effect is due to partial agonist activity at mu-opioid receptors. Buprenorphine is also a kappa-opioid receptor antagonist. The partial agoni...more Number of Targets: 4 |
| T3D2933 | Mesoridazine 5588-33-0 | C21H26N2OS2 386.574 g/mol |  |
| Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is re...more Number of Targets: 14 |
| T3D2934 | Maprotiline 10262-69-8 | C20H23N 277.403 g/mol |  |
| Maprotiline exerts its antidepressant action by inhibition of presynaptic uptake of catecholamines, thereby increasing their concentration at the synaptic clefts of th...more Number of Targets: 17 |
| T3D2935 | Diethylpropion 90-84-6 | C13H19NO 205.296 g/mol |  |
| Diethylpropion is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these i...more Number of Targets: 2 |
| T3D2936 | Aspirin 50-78-2 | C9H8O4 180.157 g/mol |  |
| The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to actions by both the acetyl and the salicylate portions of the intact molec...more Number of Targets: 18 |
| T3D2937 | Felbamate 25451-15-4 | C11H14N2O4 238.240 g/mol |  |
| The mechanism by which felbamate exerts its anticonvulsant activity is unknown, but in animal test systems designed to detect anticonvulsant activity, felbamate has pr...more Number of Targets: 3 |
| T3D2938 | Fexofenadine 83799-24-0 | C32H39NO4 501.656 g/mol |  |
| Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This b...more Number of Targets: 3 |
| T3D2939 | Naratriptan 121679-13-8 | C17H25N3O2S 335.464 g/mol |  |
| Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT1D receptors, which serves t...more Number of Targets: 4 |
| T3D2940 | Rizatriptan 145202-66-0 | C15H19N5 269.345 g/mol |  |
| Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT1D receptors, which serves t...more Number of Targets: 7 |
| T3D2941 | Hydrocodone 125-29-1 | C18H21NO3 299.364 g/mol |  |
| Hydrocodone acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Hydrocodone primarily affects OP3 receptors, which ar...more Number of Targets: 3 |
| T3D2942 | Mepivacaine 96-88-8 | C15H22N2O 246.348 g/mol |  |
| Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing ...more Number of Targets: 1 |
| T3D2951 | Neomycin 1404-04-2 | C23H46N6O13 614.644 g/mol |  |
| Aminoglycosides like neomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically neomycin binds to four nucleotides of 16S rRNA and a sing...more Number of Targets: 3 |
| T3D2952 | Gabapentin 60142-96-3 | C9H17NO2 171.237 g/mol |  |
| Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhanc...more Number of Targets: 7 |
| T3D2953 | Doxorubicin 23214-92-8 | C27H29NO11 543.519 g/mol |  |
| Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between bas...more Number of Targets: 14 |
| T3D2954 | Frovatriptan 158747-02-5 | C14H17N3O 243.304 g/mol |  |
| Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT1D receptors, which serves t...more Number of Targets: 2 |
| T3D2955 | Levobupivacaine 27262-47-1 | C18H28N2O 288.428 g/mol |  |
| Levobupivacaine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholi...more Number of Targets: 1 |
| T3D2956 | Tioconazole 65899-73-2 | C16H13Cl3N2OS 387.711 g/mol |  |
| Tioconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this wa...more Number of Targets: 2 |
| T3D2957 | Balsalazide 80573-04-2 | C17H15N3O6 357.318 g/mol |  |
| The mechanism of action of 5-aminosalicylic acid is unknown, but appears exert its anti-inflammatory effects locally (in the GI tract) rather than systemically. Mucosa...more Number of Targets: 4 |
| T3D2958 | Bethanechol 674-38-4 | C7H17N2O2 161.222 g/mol |  |
| Bethanechol directly stimulates cholinergic receptors in the parasympathetic nervous system while stimulating the ganglia to a lesser extent. Its effects are predomina...more Number of Targets: 4 |
| T3D2959 | Phytonadione 84-80-0 | C31H46O2 450.696 g/mol |  |
| Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hep...more Number of Targets: 2 |
| T3D2960 | Mycophenolic acid 24280-93-1 | C17H20O6 320.337 g/mol |  |
| Mycophenolic acid is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pa...more Number of Targets: 5 |
| T3D2961 | Ketoconazole 65277-42-1 | C26H28Cl2N4O4 531.431 g/mol |  |
| Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergoste...more Number of Targets: 26 |