Browsing Toxins
Displaying toxin 2301 - 2325 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2862 | Tizanidine 51322-75-9 | C9H8ClN5S 253.711 g/mol |  |
| Tizanidine reduces spasticity by increasing presynaptic inhibition of motor neurons through agonist action at a2-adrenergic receptor sites. Number of Targets: 4 |
| T3D2863 | Amprenavir 161814-49-9 | C25H35N3O6S 505.627 g/mol |  |
| Amprenavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Number of Targets: 5 |
| T3D2864 | Naltrexone 16590-41-3 | C20H23NO4 341.401 g/mol |  |
| Naltrexone is a pure opiate antagonist and has little or no agonist activity. The mechanism of action of naltrexone in alcoholism is not understood; however, involveme...more Number of Targets: 7 |
| T3D2865 | Sufentanil 56030-54-7 | C22H30N2O2S 386.551 g/mol |  |
| Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more Number of Targets: 4 |
| T3D2866 | Flurbiprofen 5104-49-4 | C15H13FO2 244.261 g/mol |  |
| Similar to other NSAIAs, the anti-inflammatory effect of flurbiprofen occurs via reversible inhibition of cyclooxygenase (COX), the enzyme responsible for the conversi...more Number of Targets: 11 |
| T3D2867 | Apomorphine 41372-20-7 | C17H17NO2 267.322 g/mol |  |
| The precise mechanism of action of apomorphine as a treatment for Parkinson's disease is unknown, although it is believed to be due to stimulation of post-synaptic dop...more Number of Targets: 27 |
| T3D2868 | Paroxetine 61869-08-7 | C19H20FNO3 329.365 g/mol |  |
| Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the neuronal membrane, en...more Number of Targets: 17 |
| T3D2869 | Procaine 59-46-1 | C13H20N2O2 236.310 g/mol |  |
| Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is...more Number of Targets: 11 |
| T3D2870 | Trimipramine 739-71-9 | C20H26N2 294.434 g/mol |  |
| Trimipramine's mechanism of action differs from other tricyclic antidepressants. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). Number of Targets: 17 |
| T3D2871 | Risperidone 106266-06-2 | C23H27FN4O2 410.485 g/mol |  |
| Blockade of dopaminergic D2 receptors in the limbic system alleviates positive symptoms of schizophrenia such as hallucinations, delusions, and erratic behavior and sp...more Number of Targets: 32 |
| T3D2873 | Esomeprazole 161796-78-7 | C17H19N3O3S 345.416 g/mol |  |
| Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting speci...more Number of Targets: 7 |
| T3D2874 | Meclizine 569-65-3 | C25H27ClN2 390.948 g/mol |  |
| Along with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Mec...more Number of Targets: 2 |
| T3D2875 | Riluzole 1744-22-5 | C8H5F3N2OS 234.198 g/mol |  |
| The mode of action of riluzole is unknown. Its pharmacological properties include the following, some of which may be related to its effect: 1) an inhibitory effect on...more Number of Targets: 5 |
| T3D2876 | Modafinil 68693-11-8 | C15H15NO2S 273.350 g/mol |  |
| The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lea...more Number of Targets: 2 |
| T3D2877 | Scopolamine 51-34-3 | C17H21NO4 303.353 g/mol |  |
| Scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center). Number of Targets: 6 |
| T3D2881 | Tranylcypromine 155-09-9 | C9H11N 133.190 g/mol |  |
| Tranylcypromine irreversibly and nonselectively inhibits monoamine oxidase (MAO). Within neurons, MAO appears to regulate the levels of monoamines released upon synapt...more Number of Targets: 4 |
| T3D2882 | Isoflurane 26675-46-7 | C3H2ClF5O 184.492 g/mol |  |
| Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane...more Number of Targets: 9 |
| T3D2883 | Ethotoin 86-35-1 | C11H12N2O2 204.225 g/mol |  |
| The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to p...more Number of Targets: 2 |
| T3D2884 | 9-cis-Retinoic acid 302-79-4 | C20H28O2 300.435 g/mol |  |
| Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leuke...more Number of Targets: 25 |
| T3D2886 | Olopatadine 113806-05-6 | C21H23NO3 337.412 g/mol |  |
| Olopatadine is a selective histamine H1 antagonist that binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to...more Number of Targets: 6 |
| T3D2887 | Oxcarbazepine 28721-07-5 | C15H12N2O2 252.268 g/mol |  |
| The exact mechanism by which oxcarbazepine exerts its anticonvulsant effect is unknown. It is known that the pharmacological activity of oxcarbazepine occurs primarily...more Number of Targets: 1 |
| T3D2888 | Propiomazine 362-29-8 | C20H24N2OS 340.482 g/mol |  |
| Propiomazine is an antagonist at types 1, 2, and 4 dopamine receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors,...more Number of Targets: 14 |
| T3D2889 | Phenelzine 51-71-8 | C8H12N2 136.194 g/mol |  |
| Although the exact mechanism of action has not been determined, it appears that the irreversible, nonselective inhibition of MAO by phenelzine relieves depressive symp...more Number of Targets: 11 |
| T3D2892 | Sulfasalazine 599-79-1 | C18H14N4O5S 398.393 g/mol |  |
| The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the a...more Number of Targets: 18 |
| T3D2893 | Halazepam 23092-17-3 | C17H12ClF3N2O 352.738 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity...more Number of Targets: 18 |