Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0248 | 2,4-Dichlorophenoxyacetic acid 94-75-7 | C8H6Cl2O3 221.037 g/mol |  |
| 2,4-Dichlorophenoxyacetic acid is a strong oxidant and is known to cause lipid peroxidation and the generation of free radicals that can modify lipids and proteins. It...more Number of Targets: 9 |
| T3D0249 | Dibromochloromethane 124-48-1 | CHBr2Cl 208.280 g/mol |  |
| Dibromochloromethane is oxidized into trihalomethanol by the cytochrome P-450 mixed function oxidase system of liver. Trihalomethanol then decomposes by loss of hydrog...more Number of Targets: 2 |
| T3D0252 | N,N-Dimethylformamide 1968-12-02 | C3H7NO 73.094 g/mol |  |
| While the mechanism of action of dimethyl formamide has not bee fully elucidated, thiocarbamate pesticides have been shown to inhibit aldehyde dehydrogenases. (A2459) Number of Targets: 4 |
| T3D0253 | Pyrene 129-00-0 | C16H10 202.251 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 8 |
| T3D0255 | Ethyl ether 60-29-7 | C4H10O 74.122 g/mol |  |
| Diethyl ether inhibits alcohol dehydrogenase. This slows down the metabolism of ethanol and also inhibits the metabolism of other drugs requiring oxidative metabolism....more Number of Targets: 8 |
| T3D0257 | 4-Nitrophenol 100-02-7 | C6H5NO3 139.109 g/mol |  |
| The nitrite in nitrophenols causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a con...more Number of Targets: 12 |
| T3D0259 | Phosphine 7803-51-2 | H3P 33.998 g/mol |  |
| Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to...more Number of Targets: 20 |
| T3D0261 | 2,6-Dinitrotoluene 606-20-2 | C7H6N2O4 182.134 g/mol |  |
| Dinitrotoluene may cause conversion of oxyhemoglobin to methemoglobin via oxidation of iron(II) to iron(III) by its metabolites. High levels of methemoglobin are remov...more Number of Targets: 12 |
| T3D0264 | Methyl parathion 298-00-0 | C8H10NO5PS 263.207 g/mol |  |
| Methyl parathion is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylchol...more Number of Targets: 14 |
| T3D0265 | Pentaerythritol tetranitrate 1978-11-05 | C5H8N4O12 316.137 g/mol |  |
| Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and met...more Number of Targets: 10 |
| T3D0271 | Styrene 100-42-5 | C8H8 104.149 g/mol |  |
| Styrene 7,8-oxide, a metabolite of styrene, can form DNA adducts by binding to deoxyguanosine. It is also mutagenic and causes increased frequency of sister chromatid ...more Number of Targets: 1 |
| T3D0275 | Adamsite 578-94-9 | C12H9AsClN 277.581 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 45 |
| T3D0276 | Arsenic trisulfide 1303-33-9 | As4S6 492.076 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0277 | Arsenic disulfide 1303-32-8 | AsHS 107.995 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0278 | Arsenic pentasulfide 1303-34-0 | As2H10S5 320.248 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0279 | Arsenic trichloride 7784-34-1 | AsCl3 181.281 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0282 | Arsenous acid 13464-58-9 | AsH3O3 125.944 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0285 | Ammonium arsenate 7784-44-3 | AsH9N2O4 176.004 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0286 | Copper(II) arsenite 10290-12-7 | AsCuHO3 187.474 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 49 |
| T3D0287 | Gallium arsenide 1303-00-0 | AsGa 144.645 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0288 | Copper arsenate 10103-61-4 | As2Cu3O8 468.476 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 49 |
| T3D0289 | Copper arsenate hydroxide 16102-92-4 | AsCu2HO5 283.019 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 49 |
| T3D0290 | Potassium arsenite 10124-50-2 | AsKO3 162.018 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0292 | Arsenic pentoxide 1303-28-2 | As2O5 229.840 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0293 | Magnesium arsenate 10103-50-1 | As2Mg3O8 350.753 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 45 |