Browsing Toxins
Displaying toxin 3451 - 3475 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4763 | Cyclohexanol 108-93-0 | C6H12O 100.159 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4764 | Erythromycin 114-07-8 | C37H67NO13 733.927 g/mol |  |
| Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor site so that bi...more Number of Targets: 1 |
| T3D4765 | Tolazamide 1156-19-0 | C14H21N3O3S 311.400 g/mol |  |
| Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the...more Number of Targets: 3 |
| T3D4766 | N-Decane 124-18-5 | C10H22 142.282 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D4767 | Hydroxyurea 127-07-1 | CH4N2O2 76.055 g/mol |  |
| Hydroxyurea is converted to a free radical nitroxide (NO) in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at the active sit...more Number of Targets: 2 |
| T3D4768 | Flutamide 13311-84-7 | C11H11F3N2O3 276.212 g/mol |  |
| Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition Flutamid...more Number of Targets: 7 |
| T3D4769 | Ethanolamine 141-43-5 | C2H7NO 61.083 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D4770 | Tioguanine 154-42-7 | C5H5N5S 167.192 g/mol |  |
| Thioguanine competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is itself converted to 6-thioguanilyic ...more Number of Targets: 6 |
| T3D4771 | Celecoxib 169590-42-5 | C17H14F3N3O2S 381.372 g/mol |  |
| The mechanism of action of celecoxib is believed to be due to inhibition of prostaglandin synthesis. Unlike most NSAIDs, which inhibit both types of cyclooxygenases (C...more Number of Targets: 7 |
| T3D4772 | Stavudine 3056-17-5 | C10H12N2O4 224.213 g/mol |  |
| Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Number of Targets: 1 |
| T3D4773 | Capric acid 334-48-5 | C10H20O2 172.265 g/mol |  |
| It has been demonstrated that octanoic (OA) and decanoic (DA) acids compromise the glycolytic pathway and citric acid cycle functioning, increase oxygen consumption in...more Number of Targets: 4 |
| T3D4774 | Cladribine 4291-63-8 | C10H12ClN5O3 285.687 g/mol |  |
| Cladribine is structurally related to fludarabine and pentostatin but has a different mechanism of action. Although the exact mechanism of action has not been fully de...more Number of Targets: 14 |
| T3D4775 | Fenofibrate 49562-28-9 | C20H21ClO4 360.831 g/mol |  |
| Fenofibrate exerts its therapeutic effects through activation of peroxisome proliferator activated receptor a (PPARa). This increases lipolysis and elimination of trig...more Number of Targets: 4 |
| T3D4776 | Fluorouracil 51-21-8 | C4H3FN2O2 130.077 g/mol |  |
| The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the dr...more Number of Targets: 5 |
| T3D4777 | Isoniazid 54-85-3 | C6H7N3O 137.139 g/mol |  |
| Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-per...more Number of Targets: 3 |
| T3D4778 | Propylene glycol 57-55-6 | C3H8O2 76.094 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4779 | Pyrimethamine 58-14-0 | C12H13ClN4 248.711 g/mol |  |
| Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis a...more Number of Targets: 10 |
| T3D4780 | Theophylline 58-55-9 | C7H8N4O2 180.164 g/mol |  |
| Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, an...more Number of Targets: 9 |
| T3D4781 | Hydrochlorothiazide 58-93-5 | C7H8ClN3O4S2 297.739 g/mol |  |
| Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tub...more Number of Targets: 9 |
| T3D4782 | Pentadecane 629-62-9 | C15H32 212.415 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4783 | Nilutamide 63612-50-0 | C12H10F3N3O4 317.221 g/mol |  |
| Nilutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin that stimulate ...more Number of Targets: 4 |
| T3D4784 | Clofibrate 637-07-0 | C12H15ClO3 242.699 g/mol |  |
| Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are ...more Number of Targets: 2 |
| T3D4785 | Benzoic acid 65-85-0 | C7H6O2 122.121 g/mol |  |
| Not Available Number of Targets: 5 |
| T3D4786 | Didanosine 69655-05-6 | C10H12N4O3 236.227 g/mol |  |
| Didanosine (ddI) is metabolized intracellularly by a series of cellular enzymes to its active moiety, dideoxyadenosine triphosphate (ddATP), which inhibits the HIV rev...more Number of Targets: 2 |
| T3D4787 | Lovastatin 75330-75-5 | C24H36O5 404.540 g/mol |  |
| Lovastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Lovastatin is a prodrug that is activated in vivo via hy...more Number of Targets: 10 |