Browsing Toxins
Displaying toxin 2626 - 2650 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3580 | Sodium fluoroacetate 62-74-8 | C2H2FNaO2 100.024 g/mol |  |
| Fluoroacetate is similar to acetate, which has a pivotal role in cellular metabolism. Fluoroacetate disrupts the citric acid cycle by combining with coenzyme A to form...more Number of Targets: 0 |
| T3D3582 | Lysergic Acid Diethylamide 50-37-3 | C20H25N3O 323.432 g/mol |  |
| LSD preferentially inhibits serotonergic cell firing by acting as an agonist at the 5-HT1A receptors in the raphe nuclei, locus coeruleus, and cortex. It also acts as ...more Number of Targets: 17 |
| T3D3583 | Botulinum toxin 93384-43-1 | Not Available 149452.615 g/mol |  |
| Botulinum toxin is a two-chain polypeptide with a 100-kDa heavy chain joined by a disulfide bond to a 50-kDa light chain. Following the attachment of the toxin heavy c...more Number of Targets: 2 |
| T3D3584 | Botulinum neurotoxin type G Not Available | Not Available 149033.235 g/mol |  |
| Botulinum toxin is a two-chain polypeptide with a 100-kDa heavy chain joined by a disulfide bond to a 50-kDa light chain. Following the attachment of the toxin heavy c...more Number of Targets: 0 |
| T3D3585 | beta-Amanitin 21150-22-1 | Not Available 3445.915 g/mol |  |
| The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more Number of Targets: 14 |
| T3D3586 | gamma-Amanitin 21150-23-2 | Not Available 3706.230 g/mol |  |
| The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more Number of Targets: 14 |
| T3D3587 | epsilon-Amanitin 21705-02-2 | C39H53N9O14S 903.955 g/mol |  |
| The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more Number of Targets: 14 |
| T3D3588 | Amanullin 21803-57-6 | C39H54N10O12S 886.971 g/mol |  |
| The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more Number of Targets: 14 |
| T3D3589 | Amanullinic acid 54532-45-5 | C39H53N9O13S 887.956 g/mol |  |
| The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more Number of Targets: 14 |
| T3D3590 | Amaninamide 58311-65-2 | C39H54N10O13S 902.970 g/mol |  |
| The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more Number of Targets: 14 |
| T3D3591 | Amanin 21150-21-0 | C39H53N9O14S 903.955 g/mol |  |
| The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more Number of Targets: 14 |
| T3D3592 | Proamanullin 54532-46-6 | C39H54N10O11S 870.971 g/mol |  |
| The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more Number of Targets: 14 |
| T3D3596 | Iodine 7553-56-2 | I2 253.809 g/mol |  |
| Iodide inhibits adenylate cyclase in thyroid gland follicle cells and decreases the TSH-induced rise in intracellular cAMP. This results in decreased iodination of thy...more Number of Targets: 10 |
| T3D3597 | Citrinin 518-75-2 | C13H14O5 250.247 g/mol |  |
| Citrinin produces proximal tubular necrosis, but only after transport into proximal tubular cells. It utilizes the organic anion transporter for entry into the cells, ...more Number of Targets: 28 |
| T3D3598 | Aflatoxin B1 1162-65-8 | C17H12O6 312.274 g/mol |  |
| Aflatoxin B1 requires epoxidation to aflatoxin B1 2,3-oxide for activation, which is performed by cytochome P-450 enzymes CYP1A2 and CYP3A4. It produces DNA damage, ge...more Number of Targets: 11 |
| T3D3599 | 2-Aminophenol 95-55-6 | C6H7NO 109.126 g/mol |  |
| 2-Aminophenol interacts with both adult and fetal hemoglobin, forming methemoglobin. In comparison to its isomers, 3-aminophenol and 4-aminophenol, 2-aminophenol is th...more Number of Targets: 9 |
| T3D3600 | 4-Aminophenol 123-30-8 | C6H7NO 109.126 g/mol |  |
| 4-Aminobiphenyl requires metabolic activation in order to exert its toxicity. This is catalyzed by N-hydroxylation via cytochrome P450 1A2, then followed by O-sulfatio...more Number of Targets: 6 |
| T3D3601 | 3-Aminophenol 591-27-5 | C6H7NO 109.126 g/mol |  |
| 3-Aminophenol interacts with both adult and fetal hemoglobin, forming methemoglobin. In comparison to its isomers, 2-aminophenol and 4-aminophenol, 3-aminophenol is th...more Number of Targets: 15 |
| T3D3602 | Microcystin-LR 101043-37-2 | Not Available Not Available |  |
| The site of action of microcystins is the hepatocyte, the commonest cell type in the liver. They act by disrupting the cytoskeleton, the adaptable protein framework th...more Number of Targets: 24 |
| T3D3603 | Fumonisin B1 116355-83-0 | C34H59NO15 721.830 g/mol |  |
| Fumonisins are similar in structure to the long-chain base backbones of sphingolipids, allowing it to inhibit of the biosynthesis of sphingosine and more complex sphin...more Number of Targets: 16 |
| T3D3604 | Gliotoxin 67-99-2 | C13H14N2O4S2 326.391 g/mol |  |
| Gliotoxin possesses immunosuppressive properties as it may suppress and cause apoptosis in certain types of cells of the immune system, including neutrophils, eosinop...more Number of Targets: 12 |
| T3D3605 | Ochratoxin A 303-47-9 | C20H18ClNO6 403.813 g/mol |  |
| Ochratoxin A has been shown to be weakly mutagenic, possibly by induction of oxidative DNA damage. The nephrotoxin ochratoxin A (OTA) causes a reduction of glomerular ...more Number of Targets: 5 |
| T3D3606 | Ochratoxin B 4825-86-9 | C20H19NO6 369.368 g/mol |  |
| Ochratoxin B is thought to inhibit the accumulation of cartilage proteoglycans and general protein synthesis in a concentration-related manner. (A2872) Number of Targets: 0 |
| T3D3607 | Ochratoxin C 4865-85-4 | C22H22ClNO6 431.866 g/mol |  |
| Ochratoxin A, a metabolite of Ochratoxin C, has been shown to be weakly mutagenic, possibly by induction of oxidative DNA damage. The nephrotoxin ochratoxin A (OTA) ca...more Number of Targets: 3 |
| T3D3608 | Microcystin-YR 101064-48-6 | C52H72N10O13 1045.187 g/mol |  |
| The site of action of microcystins is the hepatocyte, the commonest cell type in the liver. They act by disrupting the cytoskeleton, the adaptable protein framework th...more Number of Targets: 23 |