Browsing Toxins
Displaying toxin 2576 - 2600 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3499 | Darifenacin 133099-04-4 | C28H30N2O2 426.550 g/mol |  |
| Darifenacin selectively antagonizes the muscarinic M3 receptor. M3 receptors are involved in contraction of human bladder and gastrointestinal smooth muscle, saliva pr...more Number of Targets: 5 |
| T3D3501 | Docetaxel 114977-28-5 | C43H53NO14 807.879 g/mol |  |
| Docetaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, docetaxel arrest...more Number of Targets: 9 |
| T3D3503 | Fenthion 55-38-9 | C10H15O3PS2 278.328 g/mol |  |
| Fenthion is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 13 |
| T3D3504 | Fluoroacetic acid 144-49-0 | C2H3FO2 78.042 g/mol |  |
| Fluoroacetate is similar to acetate, which has a pivotal role in cellular metabolism. Fluoroacetate disrupts the citric acid cycle by combining with coenzyme A to form...more Number of Targets: 2 |
| T3D3507 | Capecitabine 154361-50-9 | C15H22FN3O6 359.350 g/mol |  |
| Capecitabine is a prodrug that is selectively tumour-activated to its cytotoxic moiety, fluorouracil, by thymidine phosphorylase. Fluorouracil is further metabolized t...more Number of Targets: 4 |
| T3D3512 | Hydroxychloroquine 118-42-3 | C18H26ClN3O 335.872 g/mol |  |
| Although the exact mechanism of action is unknown, it may be based on ability of hydroxychloroquine to bind to and alter DNA. Hydroxychloroquine has also has been foun...more Number of Targets: 3 |
| T3D3513 | Ifosfamide 3778-73-2 | C7H15Cl2N2O2P 261.086 g/mol |  |
| After metabolic activation, active metabolites of ifosfamide alkylate or bind with many intracellular molecular structures, including nucleic acids. The cytotoxic acti...more Number of Targets: 3 |
| T3D3514 | Infliximab 170277-31-3 | Not Available 36105.695 g/mol |  |
| Infliximab neutralizes the biological activity of TNFa by binding with high affinity to the soluble and transmembrane forms of TNFa and inhibits binding of TNFa with i...more Number of Targets: 3 |
| T3D3516 | Itraconazole 84625-61-6 | C35H38Cl2N8O4 705.633 g/mol |  |
| Itraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the f...more Number of Targets: 6 |
| T3D3517 | Labetalol 36894-69-6 | C19H24N2O3 328.406 g/mol |  |
| Labetalol has two asymmetric centers and therefore, exists as a molecular complex of two diastereoisomeric pairs. Dilevalol, the R,R' stereoisomer, makes up 25% of rac...more Number of Targets: 7 |
| T3D3520 | Melamine 108-78-1 | C3H6N6 126.120 g/mol |  |
| Melamine causes carcinomas of the urinary bladder at high doses (in male rats). Formation of bladder stones occurred and these calculi are necessary for the induction ...more Number of Targets: 1 |
| T3D3521 | Metaldehyde 108-62-3 | C8H16O4 176.210 g/mol |  |
| The toxicologically active substance in metaldehyde intoxication is mainly the degradation product acetaldehyde; other toxic products are probably also formed. Acetald...more Number of Targets: 1 |
| T3D3522 | 1,1-Dimethylbiguanide 657-24-9 | C4H11N5 129.164 g/mol |  |
| Metformin's mechanisms of action differ from other classes of oral antihyperglycemic agents. Metformin decreases blood glucose levels by decreasing hepatic glucose pro...more Number of Targets: 4 |
| T3D3523 | Methyl ethyl ketone peroxide 1338-23-4 | C8H18O6 210.225 g/mol |  |
| MEPK toxicity could occur through lipid peroxidation. (L1789) Number of Targets: 0 |
| T3D3524 | Omeprazole 73590-58-6 | C17H19N3O3S 345.416 g/mol |  |
| Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifi...more Number of Targets: 6 |
| T3D3526 | Pentamidine 100-33-4 | C19H24N4O2 340.420 g/mol |  |
| The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA,...more Number of Targets: 11 |
| T3D3529 | Polymyxin B Sulfate 1405-20-5 | C56H98N16O13 1203.477 g/mol |  |
| Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysacchar...more Number of Targets: 0 |
| T3D3532 | Salvinorin A 83729-01-5 | C23H28O8 432.464 g/mol |  |
| Salvinorin A, the active component of the hallucinogenic sage Salvia divinorum, is an apparently selective and highly potent kappa-opioid receptor (KOR) agonist. Salvi...more Number of Targets: 3 |
| T3D3533 | Sorafenib 284461-73-0 | C21H16ClF3N4O3 464.825 g/mol |  |
| Sorafenib interacts with multiple intracellular (CRAF, BRAF and mutant BRAF) and cell surface kinases (KIT, FLT-3, VEGFR-2, VEGFR-3, and PDGFR-ß). Several of these kin...more Number of Targets: 18 |
| T3D3536 | Telithromycin 191114-48-4 | C43H65N5O10 812.004 g/mol |  |
| Telithromycin acts by binding to domains II and V of 23S rRNA of the 50S ribosomal subunit. By binding at domain II, telithromycin retains activity against gram-positi...more Number of Targets: 6 |
| T3D3537 | Terazosin 70024-40-7 | C19H25N5O4 387.433 g/mol |  |
| Terazosin selectively and competitively inhibits vascular postsynaptic alpha(1)-adrenergic receptors, resulting in peripheral vasodilation and a reduction of vascular ...more Number of Targets: 6 |
| T3D3539 | Thalidomide 50-35-1 | C13H10N2O4 258.230 g/mol |  |
| In patients with erythema nodosum leprosum (ENL) the mechanism of action is not fully understood. Available data from in vitro studies and preliminary clinical trials ...more Number of Targets: 10 |
| T3D3542 | Valaciclovir 124832-26-4 | C13H20N6O4 324.336 g/mol |  |
| Valaciclovir is phosphorylated by viral thymidine kinase to acyclovir triphosphate (the active metabolite) which then inhibits herpes viral DNA replication by competit...more Number of Targets: 0 |
| T3D3543 | Vancomycin 1404-90-6 | C66H75Cl2N9O24 1449.254 g/mol |  |
| The bactericidal action of vancomycin results primarily from inhibition of cell-wall biosynthesis. Specifically, vancomycin prevents incorporation of N-acetylmuramic a...more Number of Targets: 1 |
| T3D3544 | Verapamil 52-53-9 | C27H38N2O4 454.602 g/mol |  |
| Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy...more Number of Targets: 21 |