Record Information |
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Version | 2.0 |
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Creation Date | 2014-08-29 06:51:42 UTC |
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Update Date | 2014-12-24 20:26:51 UTC |
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Accession Number | T3D4497 |
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Identification |
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Common Name | Diphenylamine |
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Class | Small Molecule |
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Description | Diphenylamine is found in coriander. Diphenylamine is used for control of superficial scald in stored apples Diphenylamine is the organic compound with the formula (C6H5)2NH. It is a colourless solid, but samples are often yellow due to oxidized impurities. It is a weak base, with a KB of 10 14. With strong acids, it forms the water soluble salt. Diphenylamine belongs to the family of Aromatic Homomonocyclic Compounds. These are aromatic compounds containig only one ring, which is homocyclic. |
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Compound Type | - Amine
- Food Toxin
- Household Toxin
- Metabolite
- Natural Compound
- Organic Compound
- Pesticide
- Plant Toxin
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Chemical Structure | |
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Synonyms | Synonym | (phenylamino)-Benzene | (phenylamino)benzene | 2-Biphenylyl-N-pyridyl-Acetamide | 2-Biphenylyl-N-pyridylacetamide | Anilino-Benzene | Anilinobenzene | Benzenamine, N-phenyl-, styrenated | Big dipper | C6H5-NH-C6H5 | Deccoscald 282 | DFA | Difenylamin | Diphenpyramide | Diphenyl-amine | Diphenylamine indicator | Diphenylamine, acs | Diphenylamine, reaction product with 2,2,4-trimethylpentene | N,N-Diphenylamine | N-Fenylanilin | N-Phenyl-Aniline | N-Phenyl-Benzenamine | N-Phenylaniline | N-Phenylbenzenamine | N-Phenylbenzenamine, 9CI | N-Phenylbenzenamine, styrenated | N-Phenylbenzeneamine | Naugalube 428L | No scald | No scald dpa 283 | No-scald | No-Scald DPA 283 | Phenylaniline | Poly(diphenylamine) | Pyridyl-biphenylyl-acetamide | Scaldip | Shield dpa | Styrenated diphenylamine | Styrene, reaction product with diphenylamine |
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Chemical Formula | C12H11N |
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Average Molecular Mass | 169.222 g/mol |
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Monoisotopic Mass | 169.089 g/mol |
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CAS Registry Number | 122-39-4 |
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IUPAC Name | N-phenylaniline |
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Traditional Name | diphenylamine |
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SMILES | N(C1=CC=CC=C1)C1=CC=CC=C1 |
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InChI Identifier | InChI=1S/C12H11N/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10,13H |
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InChI Key | InChIKey=DMBHHRLKUKUOEG-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as aniline and substituted anilines. These are organic compounds containing an aminobenzene moiety. |
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Kingdom | Organic compounds |
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Super Class | Benzenoids |
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Class | Benzene and substituted derivatives |
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Sub Class | Aniline and substituted anilines |
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Direct Parent | Aniline and substituted anilines |
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Alternative Parents | |
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Substituents | - Aniline or substituted anilines
- Secondary amine
- Organic nitrogen compound
- Organopnictogen compound
- Hydrocarbon derivative
- Organonitrogen compound
- Amine
- Aromatic homomonocyclic compound
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Molecular Framework | Aromatic homomonocyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Exogenous |
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Cellular Locations | |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | |
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Chemical Roles | |
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Physical Properties |
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State | Solid |
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Appearance | White powder. |
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Experimental Properties | Property | Value |
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Melting Point | 52 - 54°C | Boiling Point | 302°C (575.6°F) | Solubility | 0.053 mg/mL at 20°C | LogP | 3.5 |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | Deposition Date | View |
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GC-MS | GC-MS Spectrum - EI-B (Non-derivatized) | splash10-014i-2900000000-0f2d7d76998f0e03ab74 | 2017-09-12 | View Spectrum | GC-MS | GC-MS Spectrum - EI-B (Non-derivatized) | splash10-014i-0900000000-86a150c3e0c06fd6c431 | 2017-09-12 | View Spectrum | GC-MS | GC-MS Spectrum - EI-B (Non-derivatized) | splash10-014i-8900000000-43ff93288efd91fa24fd | 2017-09-12 | View Spectrum | GC-MS | GC-MS Spectrum - EI-B (Non-derivatized) | splash10-014i-2900000000-0f2d7d76998f0e03ab74 | 2018-05-18 | View Spectrum | GC-MS | GC-MS Spectrum - EI-B (Non-derivatized) | splash10-014i-0900000000-86a150c3e0c06fd6c431 | 2018-05-18 | View Spectrum | GC-MS | GC-MS Spectrum - EI-B (Non-derivatized) | splash10-014i-8900000000-43ff93288efd91fa24fd | 2018-05-18 | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-014i-2900000000-95ad298f6a9717294697 | 2017-09-01 | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QFT , positive | splash10-00di-0900000000-336cf3dcad8a94f8f2fe | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QFT , positive | splash10-00di-0900000000-17db2a0cdb58bb5824c3 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QFT , positive | splash10-00di-3900000000-2a0efcae7cb8dd177041 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QFT , positive | splash10-006x-9800000000-e79da21524f340fefcd4 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QFT , positive | splash10-0006-9200000000-d3f71eb25d134e12dec6 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QFT , positive | splash10-0006-9100000000-5dfcdb1d8c44264cc153 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , positive | splash10-00di-0900000000-2283250c2cf8e7fdffbd | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , positive | splash10-00di-2900000000-3a5b94cdf663cbe3bc48 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , positive | splash10-0006-9200000000-797a3103a29e18b04c1c | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , positive | splash10-0006-9000000000-cbc979c9a66db9d0b5c4 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , positive | splash10-0006-9000000000-f417cc3873e4f1ad2c80 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - ESI-ITFT , positive | splash10-00di-0900000000-cf90bb96548b3a94c35b | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - ESI-ITFT , positive | splash10-00di-2900000000-76156abb74c363853359 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - ESI-ITFT , positive | splash10-0006-9300000000-30558c8720d9f497b7e0 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - ESI-ITFT , positive | splash10-0006-9200000000-5838e4d5ff5e8f3a9323 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - ESI-ITFT , positive | splash10-0006-9200000000-9d965a101be070305d88 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - ESI-ITFT , positive | splash10-00di-0900000000-2228916b18e1afebcbc6 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - ESI-ITFT , positive | splash10-00di-0900000000-12e21d12706763f57b90 | 2017-09-14 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - ESI-ITFT , positive | splash10-00dl-4900000000-f2aab9a54df33c3c9126 | 2017-09-14 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-00di-0900000000-00c2a79f600db264c67d | 2016-08-01 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-00di-0900000000-3f72bbc5daf7c9fd9558 | 2016-08-01 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0v4l-9700000000-f5a6b692c949f5a02f60 | 2016-08-01 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-014i-0900000000-10096022c5cd3d396374 | 2016-08-03 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-014i-0900000000-899ac00162614581a441 | 2016-08-03 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-014i-5900000000-4f65d69ee98d44ec919f | 2016-08-03 | View Spectrum | MS | Mass Spectrum (Electron Ionization) | splash10-014i-5900000000-8c8ae83e5ede4467297a | 2014-09-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 400 MHz, CDCl3, experimental) | Not Available | 2014-09-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 25.16 MHz, CDCl3, experimental) | Not Available | 2014-09-23 | View Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Diphenylamine uncouples mitochondrial oxidative phosphorylation, resulting in a decrease in hepatocellular ATP content and consequently hepatocyte injury (22). Short-term and long-term exposure in animal models results in altered haematological parameters, splenic erythropoiesis, splenic congestion and haemosiderosis (24). |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | No indication of carcinogenicity to humans (not listed by IARC). |
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Uses/Sources | This is a natural compound that is used as a pesticide. |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Normal Concentrations |
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Abnormal Concentrations |
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External Links |
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DrugBank ID | Not Available |
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HMDB ID | HMDB32562 |
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PubChem Compound ID | 11487 |
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ChEMBL ID | CHEMBL38688 |
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ChemSpider ID | 11003 |
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KEGG ID | C11016 |
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UniProt ID | Not Available |
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OMIM ID | |
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ChEBI ID | 4640 |
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BioCyc ID | Not Available |
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CTD ID | Not Available |
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Stitch ID | Not Available |
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PDB ID | Not Available |
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ACToR ID | Not Available |
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Wikipedia Link | Diphenylamine |
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References |
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Synthesis Reference | Not Available |
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MSDS | Link |
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General References | - Jitsui Y, Ohtani N: Transmission electron microscope observation of organic-inorganic hybrid thin active layers of light-emitting diodes. Nanoscale Res Lett. 2012 Oct 25;7(1):591. doi: 10.1186/1556-276X-7-591. [23095451 ]
- Ramon JG, Bittner ER: Excited state calculations on fluorene-based polymer blends: effect of stacking orientation and solvation. J Chem Phys. 2007 May 14;126(18):181101. [17508783 ]
- Shyla B, Nagendrappa G: Redox spectrophotometric method involving electrolytically generated manganese(III) sulphate with diphenylamine for the determination of ascorbic acid present in the samples of various fruits, commercial juices and sprouted food grains. Food Chem. 2013 Jun 1;138(2-3):2036-42. doi: 10.1016/j.foodchem.2012.11.076. Epub 2012 Nov 24. [23411340 ]
- para-Nitrosodiphenylamine. IARC Monogr Eval Carcinog Risk Chem Hum. 1982 Apr;27:227-33. [6955265 ]
- Nagata T, Masuda K, Maeno S, Miura I: Synthesis and structure-activity study of fungicidal anilinopyrimidines leading to mepanipyrim (KIF-3535) as an anti-Botrytis agent. Pest Manag Sci. 2004 Apr;60(4):399-407. [15119603 ]
- Benson-Smith JJ, Wilson J, Dyer-Smith C, Mouri K, Yamaguchi S, Murata H, Nelson J: Long-lived exciplex formation and delayed exciton emission in bulk heterojunction blends of silole derivative and polyfluorene copolymer: the role of morphology on exciplex formation and charge separation. J Phys Chem B. 2009 Jun 4;113(22):7794-9. doi: 10.1021/jp808671f. [19435328 ]
- Huang YS, Westenhoff S, Avilov I, Sreearunothai P, Hodgkiss JM, Deleener C, Friend RH, Beljonne D: Electronic structures of interfacial states formed at polymeric semiconductor heterojunctions. Nat Mater. 2008 Jun;7(6):483-9. doi: 10.1038/nmat2182. Epub 2008 Apr 27. [18438413 ]
- Lin Y, El-Khouly ME, Chen Y, Supur M, Gu L, Li Y, Fukuzumi S: A new cyanofluorene-triphenylamine copolymer: synthesis and photoinduced intramolecular electron transfer processes. Chemistry. 2009 Oct 19;15(41):10818-24. doi: 10.1002/chem.200900752. [19760714 ]
- Liu B, Najari A, Pan C, Leclerc M, Xiao D, Zou Y: New low bandgap dithienylbenzothiadiazole vinylene based copolymers: synthesis and photovoltaic properties. Macromol Rapid Commun. 2010 Feb 16;31(4):391-8. doi: 10.1002/marc.200900654. Epub 2009 Nov 24. [21590919 ]
- Dalby O, Birkett JW: The evaluation of solid phase micro-extraction fibre types for the analysis of organic components in unburned propellant powders. J Chromatogr A. 2010 Nov 12;1217(46):7183-8. doi: 10.1016/j.chroma.2010.09.012. Epub 2010 Sep 15. [20933233 ]
- Fun HK, Chantrapromma S, D'Silva ED, Patil PS, Dharmaprakash SM: S-Benzyl-thiouronium 4-anilinobenzene-sulfonate. Acta Crystallogr Sect E Struct Rep Online. 2008 Aug 30;64(Pt 9):o1858-9. doi: 10.1107/S160053680802727X. [21201828 ]
- Hirai Y, Uozumi Y: Heterogeneous aromatic amination of aryl halides with arylamines in water with PS-PEG resin-supported palladium complexes. Chem Asian J. 2010 Aug 2;5(8):1788-95. doi: 10.1002/asia.201000192. [20572283 ]
- Jin R, Levermore PA, Huang J, Wang X, Bradley DD, deMello JC: On the use and influence of electron-blocking interlayers in polymer light-emitting diodes. Phys Chem Chem Phys. 2009 May 14;11(18):3455-62. doi: 10.1039/b819200f. Epub 2009 Mar 6. [19421548 ]
- Sedinova V, Urbanova E, Skarda J, Jukl A: [Determination of the number of somatic cells in milk using the rapid diphenylamine DNA filter method]. Vet Med (Praha). 1985 Aug;30(8):467-75. [3929447 ]
- Agarwala S, Peh CK, Ho GW: Investigation of ionic conductivity and long-term stability of a LiI and KI coupled diphenylamine quasi-solid-state dye-sensitized solar cell. ACS Appl Mater Interfaces. 2011 Jul;3(7):2383-91. doi: 10.1021/am200296f. Epub 2011 Jun 20. [21648469 ]
- Marjanovic B, Juranic I, Ciric-Marjanovic G: Revised mechanism of Boyland-Sims oxidation. J Phys Chem A. 2011 Apr 21;115(15):3536-50. doi: 10.1021/jp111129t. Epub 2011 Mar 24. [21434676 ]
- Kim JS, Lu L, Sreearunothai P, Seeley A, Yim KH, Petrozza A, Murphy CE, Beljonne D, Cornil J, Friend RH: Optoelectronic and charge transport properties at organic-organic semiconductor interfaces: comparison between polyfluorene-based polymer blend and copolymer. J Am Chem Soc. 2008 Oct 1;130(39):13120-31. doi: 10.1021/ja803766j. Epub 2008 Sep 4. [18767836 ]
- Patterson J, Mura C: Rapid colorimetric assays to qualitatively distinguish RNA and DNA in biomolecular samples. J Vis Exp. 2013 Feb 4;(72):e50225. doi: 10.3791/50225. [23407542 ]
- Lee KP, Gopalan AI, Kim KS, Santhosh P: Synthesis and characterization of processable multi-walled carbon nanotubes-sulfonated polydiphenylamine graft copolymers. J Nanosci Nanotechnol. 2007 Oct;7(10):3386-93. [18330145 ]
- Abid-Essefi S, Bouaziz C, Golli-Bennour EE, Ouanes Z, Bacha H: Comparative study of toxic effects of zearalenone and its two major metabolites alpha-zearalenol and beta-zearalenol on cultured human Caco-2 cells. J Biochem Mol Toxicol. 2009 Jul-Aug;23(4):233-43. doi: 10.1002/jbt.20284. [19705349 ]
- Philips MF, Gopalan AI, Lee KP: Development of a novel cyano group containing electrochemically deposited polymer film for ultrasensitive simultaneous detection of trace level cadmium and lead. J Hazard Mater. 2012 Oct 30;237-238:46-54. doi: 10.1016/j.jhazmat.2012.07.069. Epub 2012 Aug 24. [22964385 ]
- Masubuchi Y, Yamada S, Horie T: Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2000 Mar;292(3):982-7. [10688613 ]
- Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.
- Conclusion on the peer review of the pesticide risk assessment of the active substance diphenylamine. EFSA Journal 2012;10(1):2486 [59 pp.]. doi:10.2903/j.efsa.2012.2486. [Link]
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Gene Regulation |
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Up-Regulated Genes | Not Available |
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Down-Regulated Genes | Not Available |
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