Record Information |
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Version | 2.0 |
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Creation Date | 2009-07-06 21:35:44 UTC |
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Update Date | 2014-12-24 20:25:47 UTC |
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Accession Number | T3D2636 |
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Identification |
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Common Name | Disintegrin echistatin (Echis carinatus) |
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Class | Protein |
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Description | Disintegrins is a peptide toxins produced by snakes of the viper family. They work by countering blood clotting steps, inhibiting the clumping of platelets. (3) |
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Compound Type | - Amide
- Amine
- Animal Toxin
- Natural Compound
- Organic Compound
- Protein
- Snake Venom
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Protein Structure | |
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Synonyms | Synonym | Carinatin | Disintegrin echistatin | Disintegrin echistatin-alpha | Platelet aggregation activation inhibitor |
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Chemical Formula | Not Available |
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Average Molecular Mass | 5424.090 g/mol |
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CAS Registry Number | Not Available |
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Sequence | Not Available |
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Chemical Taxonomy |
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Description | Not Available |
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Kingdom | Organic Compounds |
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Super Class | Organic Acids |
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Class | Carboxylic Acids and Derivatives |
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Sub Class | Amino Acids, Peptides, and Analogues |
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Direct Parent | Peptides |
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Alternative Parents | Not Available |
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Substituents | Not Available |
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Molecular Framework | Not Available |
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External Descriptors | Not Available |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Exogenous |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Liquid |
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Appearance | Clear solution. |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | >10 mg/mL | LogP | Not Available |
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Predicted Properties | Not Available |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | Deposition Date | View |
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Toxicity Profile |
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Route of Exposure | Injection (sting/bite) (4) |
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Mechanism of Toxicity | Disintegrins work by countering blood clotting steps, inhibiting the clumping of platelets. They inhibit fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex. By binding to the glycoprotein IIb-IIIa receptor on the platelet surface, they inhibit aggregation induced by ADP, thrombin, platelet-activating factor and collagen. (3) |
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Metabolism | Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | No indication of carcinogenicity to humans (not listed by IARC). |
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Uses/Sources | Disintegrins is a peptide toxins produced by snakes of the viper family. (3) |
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Minimum Risk Level | Not Available |
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Health Effects | Disintegrins counter blood clotting steps, inhibiting the clumping of platelets. (3) |
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Symptoms | Bites from snakes in the Viperidae family cause local pain, swelling, edema, skin discoloration, and ecchymosis. (1) |
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Treatment | An antivenom exists for viper venom. (2) |
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Normal Concentrations |
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| Not Available |
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Abnormal Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | Not Available |
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HMDB ID | Not Available |
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PubChem Compound ID | Not Available |
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ChEMBL ID | Not Available |
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ChemSpider ID | Not Available |
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KEGG ID | Not Available |
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UniProt ID | P17347 |
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OMIM ID | |
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ChEBI ID | Not Available |
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BioCyc ID | Not Available |
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CTD ID | Not Available |
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Stitch ID | Not Available |
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PDB ID | 1RO3 |
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ACToR ID | Not Available |
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Wikipedia Link | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | - Dreisbach, RH (1983). Handbook of Poisoning. Los Altos, California: Lange Medical Publications.
- Wikipedia. Antivenom. Last Updated 1 July 2009. [Link]
- Wikipedia. Disintegrin. Last Updated 11 June 2009. [Link]
- Wikipedia. Snake venom. Last Updated 25 July 2009. [Link]
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Gene Regulation |
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Up-Regulated Genes | Not Available |
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Down-Regulated Genes | Not Available |
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