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Displaying toxin 2401 - 2425 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D2989Chlorpheniramine
132-22-9
C16H19ClN2
274.788 g/mol
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  • Amine
  • Anti-Allergic Agent
  • Antipruritic
  • Drug
  • Food Toxin
  • Histamine Antagonist
  • Histamine H1 Antagonist
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative sympt...more
Number of Targets: 13
T3D2990Phenacemide
63-98-9
C9H10N2O2
178.188 g/mol
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  • Amide
  • Amine
  • Anticonvulsant
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Phenacemide binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronizat...more
Number of Targets: 1
T3D2991Ambenonium
7648-98-8
C28H42Cl2N4O2
537.564 g/mol
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  • Amide
  • Amine
  • Anti-Arrhythmia Agent
  • Antimyasthenic Agent
  • Drug
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Ambenonium is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more
Number of Targets: 1
T3D2992Econazole
27220-47-9
C18H15Cl3N2O
381.684 g/mol
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  • Amine
  • Antifungal Agent
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fung...more
Number of Targets: 4
T3D2993Doxepin
1668-19-5
C19H21NO
279.376 g/mol
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  • Adrenergic Uptake Inhibitor
  • Amine
  • Anti-Anxiety Agent
  • Antidepressant
  • Antidepressive Agent
  • Antidepressive Agent, Tricyclic
  • Antipruritic
  • Drug
  • Ether
  • Histamine Antagonist
  • Metabolite
  • Norepinephrine Reuptake Inhibitor
  • Organic Compound
  • Synthetic Compound
The mechanism of action of doxepin is not completely understood. It is thought that like amitriptyline, doxepin enhances the actions of norepinephrine and serotonin by...more
Number of Targets: 23
T3D2995Nefazodone
83366-66-9
C25H32ClN5O2
470.007 g/mol
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  • Amine
  • Analgesic
  • Antidepressant
  • Antidepressant, Second-Generation
  • Antidepressive Agent
  • Antidepressive Agent, Second-Generation
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Serotonin Agent
  • Synthetic Compound
Within the serotonergic system, nefazodone acts as an antagonist at type 2 serotonin (5-HT2) post-synaptic receptors and, like fluoxetine-type antidepressants, inhibit...more
Number of Targets: 14
T3D2996Desipramine
50-47-5
C18H22N2
266.381 g/mol
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  • Adrenergic Uptake Inhibitor
  • Amine
  • Antidepressant
  • Antidepressive Agent
  • Antidepressive Agent, Tricyclic
  • Drug
  • Enzyme Inhibitor
  • Metabolite
  • Norepinephrine Reuptake Inhibitor
  • Organic Compound
  • Synthetic Compound
Desipramine is a tricyclic antidepressant (TCA) that selectively blocks reuptake of norepinephrine (noradrenaline) from the neuronal synapse. It also inhibits serotoni...more
Number of Targets: 25
T3D2997Sertaconazole
99592-32-2
C20H15Cl3N2OS
437.770 g/mol
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  • Amine
  • Antifungal Agent
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Sertaconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the ...more
Number of Targets: 0
T3D2999Bupropion
34841-39-9
C13H18ClNO
239.741 g/mol
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  • Amine
  • Antidepressant
  • Antidepressant, Second-Generation
  • Antidepressive Agent, Second-Generation
  • Dopamine Uptake Inhibitor
  • Drug
  • Ester
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Bupropion selectively inhibits the neuronal reuptake of dopamine, norepinephrine, and serotonin; actions on dopaminergic systems are more significant than imipramine o...more
Number of Targets: 14
T3D3000Trimetrexate
52128-35-5
C19H23N5O3
369.418 g/mol
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  • Amine
  • Antibiotic
  • Antifungal Agent
  • Antimetabolite, Antineoplastic
  • Antiprotozoal Agent
  • Drug
  • Ether
  • Folic Acid Antagonist
  • Metabolite
  • Organic Compound
  • Synthetic Compound
In vitro studies have shown that trimetrexate is a competitive inhibitor of dihydrofolate reductase (DHFR) from bacterial, protozoan, and mammalian sources. DHFR catal...more
Number of Targets: 2
T3D3001Halothane
151-67-7
C2HBrClF3
197.382 g/mol
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  • Anesthetic
  • Anesthetic, Inhalation
  • Bromide Compound
  • Drug
  • General Anesthetic
  • Metabolite
  • Organic Compound
  • Organobromide
  • Organochloride
  • Organofluoride
  • Synthetic Compound
Halothane causes general anaethesia due to its actions on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility. Its imm...more
Number of Targets: 22
T3D3003Chloroprocaine
133-16-4
C13H19ClN2O2
270.755 g/mol
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  • Amine
  • Anesthetic, Local
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Chloroprocaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sod...more
Number of Targets: 5
T3D3004Moclobemide
71320-77-9
C13H17ClN2O2
268.739 g/mol
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  • Amide
  • Amine
  • Antidepressant
  • Antidepressive Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Monoamine Oxidase Inhibitor
  • Organic Compound
  • Organochloride
  • Synthetic Compound
The mechanism of action of moclobemide involves the selective, reversible inhibition of MAO-A. This inhibition leads to a decrease in the metabolism and destruction of...more
Number of Targets: 1
T3D3005Orphenadrine
83-98-7
C18H23NO
269.381 g/mol
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  • Amine
  • Antidyskinetic
  • Antiparkinson Agent
  • Drug
  • Ether
  • Metabolite
  • Muscarinic Antagonist
  • Muscle Relaxant, Central
  • Muscle Relaxant, Skeletal
  • Organic Compound
  • Parasympatholytic
  • Synthetic Compound
Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkine...more
Number of Targets: 16
T3D3006Phenobarbital
50-06-6
C12H12N2O3
232.235 g/mol
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  • Amide
  • Amine
  • Anticonvulsant
  • Drug
  • Excitatory Amino Acid Antagonist
  • GABA Modulator
  • Hypnotic and Sedative
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity f...more
Number of Targets: 9
T3D3007Escitalopram
128196-01-0
C20H21FN2O
324.392 g/mol
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  • Amine
  • Antidepressant, Second-Generation
  • Antidepressive Agent, Second-Generation
  • Drug
  • Ether
  • Food Toxin
  • Metabolite
  • Nitrile
  • Organic Compound
  • Organofluoride
  • Serotonin Uptake Inhibitor
  • Synthetic Compound
The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. ...more
Number of Targets: 6
T3D3009Chlormezanone
80-77-3
C11H12ClNO3S
273.736 g/mol
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  • Amide
  • Amine
  • Anti-Anxiety Agent
  • Antipsychotic Agent
  • Benzodiazepine
  • Drug
  • Metabolite
  • Muscle Relaxant, Central
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Chlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmit...more
Number of Targets: 1
T3D3010Fluoxymesterone
76-43-7
C20H29FO3
336.441 g/mol
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  • Anabolic Agent
  • Antineoplastic Agent, Hormonal
  • Drug
  • Ester
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
Fluoxymesterone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic...more
Number of Targets: 5
T3D3011Pergolide
66104-22-1
C19H26N2S
314.488 g/mol
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  • Amine
  • Antidyskinetic
  • Antiparkinson Agent
  • Central Nervous System Agent
  • Dopamine Agonist
  • Drug
  • Ether
  • Metabolite
  • Neuroprotective Agent
  • Organic Compound
  • Synthetic Compound
The dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi proteins. In lactotrophs, stimulation of dopamine D2 receptor causes inhibi...more
Number of Targets: 17
T3D3012Ciclopirox
29342-05-0
C12H17NO2
207.269 g/mol
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  • Antifungal Agent
  • Drug
  • Ester
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Unlike antifungals such as itraconazole and terbinafine, which affect sterol synthesis, ciclopirox is thought to act through the chelation of polyvalent metal cations,...more
Number of Targets: 5
T3D3013Desflurane
57041-67-5
C3H2F6O
168.038 g/mol
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  • Anesthetic, Inhalation
  • Drug
  • Metabolite
  • Neuroprotective Agent
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
Desflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Desflurane...more
Number of Targets: 8
T3D3014Dexfenfluramine
3239-44-9
C12H16F3N
231.257 g/mol
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  • Amine
  • Anti-Obesity Agent
  • Appetite Depressant
  • Drug
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Serotonin Agonist
  • Serotonin Receptor Agonist
  • Serotonin Reuptake Inhibitor
  • Serotonin Uptake Inhibitor
  • Synthetic Compound
Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor...more
Number of Targets: 4
T3D3015Oxymorphone
76-41-5
C17H19NO4
301.337 g/mol
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  • Adjuvant
  • Adjuvant, Anesthesia
  • Amine
  • Analgesic
  • Analgesic, Opioid
  • Drug
  • Ether
  • Metabolite
  • Narcotic
  • Opiate Agonist
  • Organic Compound
  • Synthetic Compound
Oxymorphone interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the poste...more
Number of Targets: 3
T3D3016Zopiclone
43200-80-2
C17H17ClN6O3
388.808 g/mol
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  • Amide
  • Amine
  • Drug
  • Ester
  • Ether
  • Hypnotic and Sedative
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. Both zopic...more
Number of Targets: 5
T3D3017Bromocriptine
25614-03-3
C32H40BrN5O5
654.595 g/mol
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  • Amide
  • Amine
  • Antidyskinetic
  • Antiparkinson Agent
  • Bromide Compound
  • Dopamine Agonist
  • Drug
  • Ether
  • Hormone Antagonist
  • Metabolite
  • Organic Compound
  • Organobromide
  • Synthetic Compound
The dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi proteins. In lactotrophs, stimulation of dopamine D2 receptor causes inhibi...more
Number of Targets: 25
Displaying toxin 2401 - 2425 of 3678 in total