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Displaying toxin 2076 - 2100 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D2550Onchidal
67656-42-2
C17H24O3
276.371 g/mol
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  • Aldehyde
  • Animal Toxin
  • Ester
  • Marine Toxin
  • Natural Compound
  • Organic Compound
Onchidal is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more
Number of Targets: 1
T3D2551Saxitoxin
35523-89-8
C10H17N7O4
299.287 g/mol
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  • Amide
  • Amine
  • Animal Toxin
  • Bacterial Toxin
  • Ester
  • Ether
  • Food Toxin
  • Marine Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
Saxitoxin blocks voltage-gated sodium channels of nerve cells. (L1115)
Number of Targets: 14
T3D2552Sticholysin
269658-04-0; 183449-91-4
Not Available
19390.885 g/mol
T3d2552
  • Amide
  • Amine
  • Animal Toxin
  • Marine Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Sticholysin is a cardiac stimulatory and hemolytic pore-forming protein. Pore formation likely proceeds by membrane binding via a surface rich in aromatic residues, fo...more
Number of Targets: 0
T3D25534-Aminopyridine
504-24-5
C5H6N2
94.115 g/mol
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  • Amine
  • Drug
  • Industrial Precursor/Intermediate
  • Organic Compound
  • Potassium Channel Blocker
  • Synthetic Compound
4-Aminopyridine blocks potassium channels and thereby increases acetylcholine, and possibly noradrenaline, release at nerve terminals (A316). In MS, axons are progress...more
Number of Targets: 17
T3D2554Baclofen
1134-47-0
C10H12ClNO2
213.661 g/mol
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  • Amine
  • Drug
  • GABA Agonist
  • Metabolite
  • Muscle Relaxant
  • Muscle Relaxant, Central
  • Muscle Relaxant, Skeletal
  • Neuromuscular Agent
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and poly...more
Number of Targets: 3
T3D2555Quetiapine
111974-69-7
C21H25N3O2S
383.507 g/mol
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  • Amine
  • Antipsychotic Agent
  • Drug
  • Ether
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Synthetic Compound
The mechanism of action of quetiapine, as with other drugs used to treat schizophrenia, is unknown. However, it is thought that the drug's therapeutic activity in schi...more
Number of Targets: 30
T3D2556Flecainide
54143-55-4
C17H20F6N2O3
414.343 g/mol
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  • Amide
  • Amine
  • Anti-Arrhythmia Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
  • Voltage-Gated Sodium Channel Blocker
Flecainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions ...more
Number of Targets: 4
T3D2557Disulfiram
97-77-8
C10H20N2S4
296.539 g/mol
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  • Alcohol Deterrent
  • Amine
  • Drug
  • Enzyme Inhibitor
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in t...more
Number of Targets: 24
T3D2558Valproic acid
99-66-1
C8H16O2
144.211 g/mol
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  • Anticonvulsant
  • Antimanic Agent
  • Drug
  • Enzyme Inhibitor
  • Food Toxin
  • GABA Agent
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Valproic Acid binds to and inhibits GABA transaminase. This leads to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter i...more
Number of Targets: 20
T3D2560Amantadine
768-94-5
C10H17N
151.249 g/mol
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  • Amine
  • Analgesic, Non-Narcotic
  • Antiparkinson Agent
  • Antiviral Agent
  • Dopamine Agent
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
The mechanism of its antiparkinsonic effect is not fully understood, but it appears to be releasing dopamine from the nerve endings of the brain cells, together with s...more
Number of Targets: 5
T3D2561Chloroquine
54-05-7
C18H26ClN3
319.872 g/mol
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  • Amebicide
  • Amine
  • Antimalarial
  • Antirheumatic Agent
  • Drug
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
The mechanism of plasmodicidal action of chloroquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. Th...more
Number of Targets: 6
T3D2562Gamma-Butyrolactone
96-48-0
C4H6O2
86.089 g/mol
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  • Ester
  • Ether
  • Food Toxin
  • Household Toxin
  • Indicator and Reagent
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Solvent
  • Synthetic Compound
Gamma-butyrolactone is rapidly converted to gamma-hydroxybutyrate. This may account for the subsequent central nervous system depressant. Gamma-butyrolactone is an ane...more
Number of Targets: 1
T3D2563Carbon dioxide
124-38-9
CO2
44.010 g/mol
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  • Food Toxin
  • Household Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Vapour
Carbon dioxide causes widespread activation of the sympathetic nervous system and an increase in the plasma concentrations of epinephrine, norepinephrine, angiotensin,...more
Number of Targets: 1
T3D2564Triazolam
28911-01-5
C17H12Cl2N4
343.210 g/mol
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  • Adjuvant, Anesthesia
  • Anti-Anxiety Agent
  • Benzodiazepine
  • Drug
  • GABA Modulator
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Benzodiazepines bind nonspecifically to bezodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity,...more
Number of Targets: 23
T3D2565Promazine
58-40-2
C17H20N2S
284.419 g/mol
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  • Amine
  • Antiemetic
  • Antipsychotic Agent
  • Dopamine Antagonist
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Phenothiazine
  • Synthetic Compound
Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine ...more
Number of Targets: 16
T3D2566Heparin
9005-49-6
C26H41NO34S4
1039.850 g/mol
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  • Animal Toxin
  • Anticoagulant
  • Drug
  • Ester
  • Fibrinolytic Agent
  • Food Toxin
  • Heparin
  • Metabolite
  • Natural Compound
  • Organic Compound
Heparin-induced thrombocytopenia (HIT) is caused by the formation of abnormal antibodies that activate platelets. Heparin occurs naturally in the human body, but the d...more
Number of Targets: 14
T3D2567Warfarin
81-81-2
C19H16O4
308.328 g/mol
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  • Anticoagulant
  • Coumarin and Indandione Rodenticide
  • Drug
  • Ester
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Pesticide
  • Rodenticide
  • Synthetic Compound
Warfarin inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of gluta...more
Number of Targets: 10
T3D2568Ceftriaxone
73384-59-5
C18H18N8O7S3
554.580 g/mol
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  • Amide
  • Amine
  • Anti-Bacterial Agent
  • Cephalosporin
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases, endopeptidases,...more
Number of Targets: 4
T3D2570Lamotrigine
84057-84-1
C9H7Cl2N5
256.091 g/mol
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  • Amine
  • Analgesic
  • Anticonvulsant
  • Antidepressant
  • Antidepressive Agent
  • Antimanic Agent
  • Calcium Channel Blocker
  • Drug
  • Excitatory Amino Acid Antagonist
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
One proposed mechanism of action of Lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. in vitro pharmacolo...more
Number of Targets: 10
T3D2571Acetaminophen
103-90-2
C8H9NO2
151.163 g/mol
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  • Amide
  • Amine
  • Analgesic, Non-Narcotic
  • Antipyretic
  • Drug
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Paracetamol toxicity is one of the most common causes of poisoning worldwide. The toxic effects of acetaminophen are due to a minor alkylating metabolite (N-acetyl-p-b...more
Number of Targets: 31
T3D2573Acrylamide
1979-06-01
C3H5NO
71.078 g/mol
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  • Amide
  • Amine
  • Cigarette Toxin
  • Cosmetic Toxin
  • Food Toxin
  • Household Toxin
  • Industrial Precursor/Intermediate
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Pollutant
  • Synthetic Compound
Acrylamide produces a central-peripheral distal axonopathy when administered chronically. This is characterized functionally by decreases in the monosynaptic reflex an...more
Number of Targets: 50
T3D2575Tramadol
27203-92-5
C16H25NO2
263.375 g/mol
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  • Amine
  • Analgesic
  • Analgesic, Opioid
  • Drug
  • Ether
  • Metabolite
  • Narcotic
  • Organic Compound
  • Synthetic Compound
Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both posi...more
Number of Targets: 9
T3D2576Haloperidol
52-86-8
C21H23ClFNO2
375.864 g/mol
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  • Amine
  • Antidyskinetic
  • Antiemetic
  • Antipsychotic Agent
  • Butyrophenone
  • Dopamine Antagonist
  • Drug
  • Ester
  • Metabolite
  • Organic Compound
  • Organochloride
  • Organofluoride
  • Synthetic Compound
The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, but the drug appears to depress the CNS at the subcortical level of the...more
Number of Targets: 26
T3D2577Varenicline
249296-44-4
C13H13N3
211.262 g/mol
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  • Amine
  • Drug
  • Metabolite
  • Nicotinic Agonist
  • Organic Compound
  • Synthetic Compound
Varenicline is an alpha-4 beta-2 neuronal nicotinic acetylcholine receptor partial agonist. The drug shows high selectiviyty for this receptor subclass, relative to ot...more
Number of Targets: 4
T3D2578Fluoroacetamide
640-19-7
C2H4FNO
77.058 g/mol
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  • Amide
  • Amine
  • Organic Compound
  • Organofluoride
  • Pesticide
  • Synthetic Compound
Fluoroacetate produces its toxin action by inhibiting the citric acid cycle. The fluorine substituted acetate becomes incorporated, as a normal acetate, into fluoroace...more
Number of Targets: 0
Displaying toxin 2076 - 2100 of 3678 in total