Browsing Toxins By Category
Displaying toxin 2076 - 2100 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2550 | Onchidal 67656-42-2 | C17H24O3 276.371 g/mol |  |
| Onchidal is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 1 |
| T3D2551 | Saxitoxin 35523-89-8 | C10H17N7O4 299.287 g/mol |  |
| Saxitoxin blocks voltage-gated sodium channels of nerve cells. (L1115) Number of Targets: 14 |
| T3D2552 | Sticholysin 269658-04-0; 183449-91-4 | Not Available 19390.885 g/mol |  |
| Sticholysin is a cardiac stimulatory and hemolytic pore-forming protein. Pore formation likely proceeds by membrane binding via a surface rich in aromatic residues, fo...more Number of Targets: 0 |
| T3D2553 | 4-Aminopyridine 504-24-5 | C5H6N2 94.115 g/mol |  |
| 4-Aminopyridine blocks potassium channels and thereby increases acetylcholine, and possibly noradrenaline, release at nerve terminals (A316). In MS, axons are progress...more Number of Targets: 17 |
| T3D2554 | Baclofen 1134-47-0 | C10H12ClNO2 213.661 g/mol |  |
| Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and poly...more Number of Targets: 3 |
| T3D2555 | Quetiapine 111974-69-7 | C21H25N3O2S 383.507 g/mol |  |
| The mechanism of action of quetiapine, as with other drugs used to treat schizophrenia, is unknown. However, it is thought that the drug's therapeutic activity in schi...more Number of Targets: 30 |
| T3D2556 | Flecainide 54143-55-4 | C17H20F6N2O3 414.343 g/mol |  |
| Flecainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions ...more Number of Targets: 4 |
| T3D2557 | Disulfiram 97-77-8 | C10H20N2S4 296.539 g/mol |  |
| Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in t...more Number of Targets: 24 |
| T3D2558 | Valproic acid 99-66-1 | C8H16O2 144.211 g/mol |  |
| Valproic Acid binds to and inhibits GABA transaminase. This leads to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter i...more Number of Targets: 20 |
| T3D2560 | Amantadine 768-94-5 | C10H17N 151.249 g/mol |  |
| The mechanism of its antiparkinsonic effect is not fully understood, but it appears to be releasing dopamine from the nerve endings of the brain cells, together with s...more Number of Targets: 5 |
| T3D2561 | Chloroquine 54-05-7 | C18H26ClN3 319.872 g/mol |  |
| The mechanism of plasmodicidal action of chloroquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. Th...more Number of Targets: 6 |
| T3D2562 | Gamma-Butyrolactone 96-48-0 | C4H6O2 86.089 g/mol |  |
| Gamma-butyrolactone is rapidly converted to gamma-hydroxybutyrate. This may account for the subsequent central nervous system depressant. Gamma-butyrolactone is an ane...more Number of Targets: 1 |
| T3D2563 | Carbon dioxide 124-38-9 | CO2 44.010 g/mol |  |
| Carbon dioxide causes widespread activation of the sympathetic nervous system and an increase in the plasma concentrations of epinephrine, norepinephrine, angiotensin,...more Number of Targets: 1 |
| T3D2564 | Triazolam 28911-01-5 | C17H12Cl2N4 343.210 g/mol |  |
| Benzodiazepines bind nonspecifically to bezodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity,...more Number of Targets: 23 |
| T3D2565 | Promazine 58-40-2 | C17H20N2S 284.419 g/mol |  |
| Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine ...more Number of Targets: 16 |
| T3D2566 | Heparin 9005-49-6 | C26H41NO34S4 1039.850 g/mol |  |
| Heparin-induced thrombocytopenia (HIT) is caused by the formation of abnormal antibodies that activate platelets. Heparin occurs naturally in the human body, but the d...more Number of Targets: 14 |
| T3D2567 | Warfarin 81-81-2 | C19H16O4 308.328 g/mol |  |
| Warfarin inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of gluta...more Number of Targets: 10 |
| T3D2568 | Ceftriaxone 73384-59-5 | C18H18N8O7S3 554.580 g/mol |  |
| Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases, endopeptidases,...more Number of Targets: 4 |
| T3D2570 | Lamotrigine 84057-84-1 | C9H7Cl2N5 256.091 g/mol |  |
| One proposed mechanism of action of Lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. in vitro pharmacolo...more Number of Targets: 10 |
| T3D2571 | Acetaminophen 103-90-2 | C8H9NO2 151.163 g/mol |  |
| Paracetamol toxicity is one of the most common causes of poisoning worldwide. The toxic effects of acetaminophen are due to a minor alkylating metabolite (N-acetyl-p-b...more Number of Targets: 31 |
| T3D2573 | Acrylamide 1979-06-01 | C3H5NO 71.078 g/mol |  |
| Acrylamide produces a central-peripheral distal axonopathy when administered chronically. This is characterized functionally by decreases in the monosynaptic reflex an...more Number of Targets: 50 |
| T3D2575 | Tramadol 27203-92-5 | C16H25NO2 263.375 g/mol |  |
| Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both posi...more Number of Targets: 9 |
| T3D2576 | Haloperidol 52-86-8 | C21H23ClFNO2 375.864 g/mol |  |
| The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, but the drug appears to depress the CNS at the subcortical level of the...more Number of Targets: 26 |
| T3D2577 | Varenicline 249296-44-4 | C13H13N3 211.262 g/mol |  |
| Varenicline is an alpha-4 beta-2 neuronal nicotinic acetylcholine receptor partial agonist. The drug shows high selectiviyty for this receptor subclass, relative to ot...more Number of Targets: 4 |
| T3D2578 | Fluoroacetamide 640-19-7 | C2H4FNO 77.058 g/mol |  |
| Fluoroacetate produces its toxin action by inhibiting the citric acid cycle. The fluorine substituted acetate becomes incorporated, as a normal acetate, into fluoroace...more Number of Targets: 0 |