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Displaying toxin 2576 - 2600 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D3499Darifenacin
133099-04-4
C28H30N2O2
426.550 g/mol
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  • Amide
  • Amine
  • Antispasmodic Agent
  • Drug
  • Ether
  • Metabolite
  • Muscarinic Antagonist
  • Organic Compound
  • Synthetic Compound
  • Urinary Antispasmodic
Darifenacin selectively antagonizes the muscarinic M3 receptor. M3 receptors are involved in contraction of human bladder and gastrointestinal smooth muscle, saliva pr...more
Number of Targets: 5
T3D3501Docetaxel
114977-28-5
C43H53NO14
807.879 g/mol
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  • Amine
  • Antimalarial
  • Antineoplastic Agent
  • Antineoplastic Agent, Phytogenic
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Radiation-Sensitizing Agent
  • Synthetic Compound
Docetaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, docetaxel arrest...more
Number of Targets: 9
T3D3503Fenthion
55-38-9
C10H15O3PS2
278.328 g/mol
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  • Ester
  • Ether
  • Food Toxin
  • Organic Compound
  • Organophosphate
  • Pesticide
  • Synthetic Compound
Fenthion is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more
Number of Targets: 13
T3D3504Fluoroacetic acid
144-49-0
C2H3FO2
78.042 g/mol
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  • Organic Compound
  • Organofluoride
  • Pesticide
  • Synthetic Compound
Fluoroacetate is similar to acetate, which has a pivotal role in cellular metabolism. Fluoroacetate disrupts the citric acid cycle by combining with coenzyme A to form...more
Number of Targets: 2
T3D3507Capecitabine
154361-50-9
C15H22FN3O6
359.350 g/mol
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  • Amine
  • Antimetabolite
  • Antimetabolite, Antineoplastic
  • Antineoplastic Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Prodrug
  • Synthetic Compound
Capecitabine is a prodrug that is selectively tumour-activated to its cytotoxic moiety, fluorouracil, by thymidine phosphorylase. Fluorouracil is further metabolized t...more
Number of Targets: 4
T3D3512Hydroxychloroquine
118-42-3
C18H26ClN3O
335.872 g/mol
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  • Amine
  • Antimalarial
  • Antirheumatic Agent
  • Dermatologic Agent
  • Drug
  • Enzyme Inhibitor
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Although the exact mechanism of action is unknown, it may be based on ability of hydroxychloroquine to bind to and alter DNA. Hydroxychloroquine has also has been foun...more
Number of Targets: 3
T3D3513Ifosfamide
3778-73-2
C7H15Cl2N2O2P
261.086 g/mol
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  • Amide
  • Antineoplastic Agent
  • Antineoplastic Agent, Alkylating
  • Drug
  • Ester
  • Immunosuppressive Agent
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
After metabolic activation, active metabolites of ifosfamide alkylate or bind with many intracellular molecular structures, including nucleic acids. The cytotoxic acti...more
Number of Targets: 3
T3D3514Infliximab
170277-31-3
Not Available
36105.695 g/mol
T3d3514
  • Amide
  • Amine
  • Animal Toxin
  • Anti-Inflammatory Agent, Non-Steroidal
  • Antirheumatic Agent
  • Dermatologic Agent
  • Gastrointestinal Agent
  • Immunomodulatory Agent
  • Immunosuppressive Agent
  • Organic Compound
  • Protein
  • Synthetic Compound
Infliximab neutralizes the biological activity of TNFa by binding with high affinity to the soluble and transmembrane forms of TNFa and inhibits binding of TNFa with i...more
Number of Targets: 3
T3D3516Itraconazole
84625-61-6
C35H38Cl2N8O4
705.633 g/mol
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  • 14-alpha Demethylase Inhibitor
  • Amine
  • Antifungal Agent
  • Antiprotozoal Agent
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Itraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the f...more
Number of Targets: 6
T3D3517Labetalol
36894-69-6
C19H24N2O3
328.406 g/mol
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  • Adrenergic alpha-1 Receptor Antagonist
  • Adrenergic alpha-Antagonist
  • Adrenergic beta-Antagonist
  • Amide
  • Amine
  • Antihypertensive Agent
  • Drug
  • Ester
  • Metabolite
  • Organic Compound
  • Sympatholytic
  • Sympathomimetic
  • Synthetic Compound
Labetalol has two asymmetric centers and therefore, exists as a molecular complex of two diastereoisomeric pairs. Dilevalol, the R,R' stereoisomer, makes up 25% of rac...more
Number of Targets: 7
T3D3520Melamine
108-78-1
C3H6N6
126.120 g/mol
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  • Amine
  • Aromatic Hydrocarbon
  • Food Toxin
  • Household Toxin
  • Industrial Precursor/Intermediate
  • Industrial/Workplace Toxin
  • Lachrymator
  • Metabolite
  • Organic Compound
  • Pesticide
  • Synthetic Compound
Melamine causes carcinomas of the urinary bladder at high doses (in male rats). Formation of bladder stones occurred and these calculi are necessary for the induction ...more
Number of Targets: 1
T3D3521Metaldehyde
108-62-3
C8H16O4
176.210 g/mol
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  • Household Toxin
  • Lachrymator
  • Organic Compound
  • Pesticide
  • Synthetic Compound
The toxicologically active substance in metaldehyde intoxication is mainly the degradation product acetaldehyde; other toxic products are probably also formed. Acetald...more
Number of Targets: 1
T3D35221,1-Dimethylbiguanide
657-24-9
C4H11N5
129.164 g/mol
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  • Amide
  • Amine
  • Antidiabetic Agent
  • Drug
  • Food Toxin
  • Hypoglycemic Agent
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Metformin's mechanisms of action differ from other classes of oral antihyperglycemic agents. Metformin decreases blood glucose levels by decreasing hepatic glucose pro...more
Number of Targets: 4
T3D3523Methyl ethyl ketone peroxide
1338-23-4
C8H18O6
210.225 g/mol
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  • Explosive Agent
  • Household Toxin
  • Industrial Precursor/Intermediate
  • Industrial/Workplace Toxin
  • Organic Compound
  • Synthetic Compound
MEPK toxicity could occur through lipid peroxidation. (L1789)
Number of Targets: 0
T3D3524Omeprazole
73590-58-6
C17H19N3O3S
345.416 g/mol
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  • Anti-Ulcer Agent
  • Drug
  • Enzyme Inhibitor
  • Ether
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Proton Pump Inhibitor
  • Synthetic Compound
Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifi...more
Number of Targets: 6
T3D3526Pentamidine
100-33-4
C19H24N4O2
340.420 g/mol
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  • Amide
  • Amine
  • Antifungal Agent
  • Antiprotozoal Agent
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
  • Trypanocidal Agent
The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA,...more
Number of Targets: 11
T3D3529Polymyxin B Sulfate
1405-20-5
C56H98N16O13
1203.477 g/mol
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  • Amide
  • Amine
  • Anti-Bacterial Agent
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysacchar...more
Number of Targets: 0
T3D3532Salvinorin A
83729-01-5
C23H28O8
432.464 g/mol
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  • Ester
  • Ether
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Salvinorin A, the active component of the hallucinogenic sage Salvia divinorum, is an apparently selective and highly potent kappa-opioid receptor (KOR) agonist. Salvi...more
Number of Targets: 3
T3D3533Sorafenib
284461-73-0
C21H16ClF3N4O3
464.825 g/mol
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  • Amide
  • Amine
  • Anticancer Agent
  • Antineoplastic Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Organofluoride
  • Protein Kinase Inhibitor
  • Synthetic Compound
Sorafenib interacts with multiple intracellular (CRAF, BRAF and mutant BRAF) and cell surface kinases (KIT, FLT-3, VEGFR-2, VEGFR-3, and PDGFR-ß). Several of these kin...more
Number of Targets: 18
T3D3536Telithromycin
191114-48-4
C43H65N5O10
812.004 g/mol
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  • Amine
  • Anti-Bacterial Agent
  • Drug
  • Ester
  • Ether
  • Ketolide
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Telithromycin acts by binding to domains II and V of 23S rRNA of the 50S ribosomal subunit. By binding at domain II, telithromycin retains activity against gram-positi...more
Number of Targets: 6
T3D3537Terazosin
70024-40-7
C19H25N5O4
387.433 g/mol
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  • Adrenergic alpha-1 Receptor Antagonist
  • Adrenergic alpha-Antagonist
  • Amide
  • Amine
  • Antineoplastic Agent
  • Drug
  • Ether
  • Organic Compound
  • Platelet Aggregation Inhibitor
  • Synthetic Compound
Terazosin selectively and competitively inhibits vascular postsynaptic alpha(1)-adrenergic receptors, resulting in peripheral vasodilation and a reduction of vascular ...more
Number of Targets: 6
T3D3539Thalidomide
50-35-1
C13H10N2O4
258.230 g/mol
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  • Amide
  • Amine
  • Angiogenesis Inhibitor
  • Drug
  • Ester
  • Immunosuppressive Agent
  • Leprostatic Agent
  • Metabolite
  • Organic Compound
  • Synthetic Compound
  • Teratogen
In patients with erythema nodosum leprosum (ENL) the mechanism of action is not fully understood. Available data from in vitro studies and preliminary clinical trials ...more
Number of Targets: 10
T3D3542Valaciclovir
124832-26-4
C13H20N6O4
324.336 g/mol
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  • Amide
  • Amine
  • Antiviral Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Prodrug
  • Synthetic Compound
Valaciclovir is phosphorylated by viral thymidine kinase to acyclovir triphosphate (the active metabolite) which then inhibits herpes viral DNA replication by competit...more
Number of Targets: 0
T3D3543Vancomycin
1404-90-6
C66H75Cl2N9O24
1449.254 g/mol
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  • Amine
  • Anti-Bacterial Agent
  • Drug
  • Ether
  • Glycopeptide Antibacterial
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
The bactericidal action of vancomycin results primarily from inhibition of cell-wall biosynthesis. Specifically, vancomycin prevents incorporation of N-acetylmuramic a...more
Number of Targets: 1
T3D3544Verapamil
52-53-9
C27H38N2O4
454.602 g/mol
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  • Amine
  • Anti-Arrhythmia Agent
  • Calcium Channel Blocker
  • Cyanide Compound
  • Drug
  • Ether
  • Food Toxin
  • Metabolite
  • Nitrile
  • Organic Compound
  • Synthetic Compound
  • Vasodilator Agent
Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy...more
Number of Targets: 21
Displaying toxin 2576 - 2600 of 3678 in total