Browsing Toxins By Category
Displaying toxin 2276 - 2300 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3766 | Janthitrem G 90986-51-9 | C39H51NO6 629.825 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 22 |
| T3D1855 | Jasmolin I 4466-14-2 | C21H30O3 330.461 g/mol |  |
| Pyrethrins exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to the membrane lipid phase in...more Number of Targets: 20 |
| T3D1856 | Jasmolin II 1172-63-0 | C22H30O5 374.471 g/mol |  |
| Pyrethrins exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to the membrane lipid phase in...more Number of Targets: 20 |
| T3D4083 | Jervine 469-59-0 | C27H39NO3 425.604 g/mol |  |
| Jervine's biological activity is mediated via its interaction with the 7 pass trans membrane protein smoothened. Jervine binds with and inhibits smoothened, which is a...more Number of Targets: 3 |
| T3D4795 | Kaempferol 520-18-3 | C15H10O6 286.236 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D2515 | Kaliotoxin 145199-73-1 | Not Available 6461.905 g/mol |  |
| Kaliotoxin is a neurotoxin that binds to voltage-gated and calcium-activated potassium channels. It binds to the extracellular surface and blocks the channel, affectin...more Number of Targets: 6 |
| T3D2516 | Kaliotoxin-1 150769-72-5 | Not Available 4155.975 g/mol |  |
| Kaliotoxin is a neurotoxin that binds to voltage-gated and calcium-activated potassium channels. It binds to the extracellular surface and blocks the channel, affectin...more Number of Targets: 6 |
| T3D2517 | Kaliotoxin-2 159605-22-8 | Not Available 6392.840 g/mol |  |
| Kaliotoxin is a neurotoxin that binds to voltage-gated and calcium-activated potassium channels. It binds to the extracellular surface and blocks the channel, affectin...more Number of Targets: 6 |
| T3D2518 | Kaliotoxin-3 223246-26-2 | Not Available 4027.840 g/mol | |
| Kaliotoxin is a neurotoxin that binds to voltage-gated and calcium-activated potassium channels. It binds to the extracellular surface and blocks the channel, affectin...more Number of Targets: 6 |
| T3D2628 | kappa-Atracotoxin (Hadronyche versuta) Not Available | Not Available 3685.155 g/mol |  |
| kappa-Atracotoxins inhibit insect voltage-gated potassium channels. (T170, L1812) Number of Targets: 0 |
| T3D2659 | kappa-Conotoxin (Conus purpurascens) Not Available | Not Available 8316.795 g/mol |  |
| kappa-Conotoxins inhibit potassium channels. (L1107) Number of Targets: 23 |
| T3D2511 | kappa-Hefutoxin 478621-50-0 | Not Available 2659.865 g/mol |  |
| kappa-Hefutoxin blocks voltage-gated potassium channels and also slows down their activation kinetics. (L1048) Number of Targets: 2 |
| T3D0978 | Karbutilate 4849-32-5 | C14H21N3O3 279.335 g/mol |  |
| Karbutilate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active site...more Number of Targets: 2 |
| T3D3025 | Ketamine 6740-88-1 | C13H16ClNO 237.725 g/mol |  |
| Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some...more Number of Targets: 12 |
| T3D4571 | Ketazolam 27223-35-4 | C20H17ClN2O3 368.814 g/mol |  |
| Benzodiazepines share a similar chemical structure and their effects in humans are mainly produced by the allosteric modification of a specific kind of neurotransmitte...more Number of Targets: 18 |
| T3D2961 | Ketoconazole 65277-42-1 | C26H28Cl2N4O4 531.431 g/mol |  |
| Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergoste...more Number of Targets: 26 |
| T3D4426 | Ketoleucine 816-66-0 | C6H10O3 130.142 g/mol |  |
| Ketoleucine is a metabolite that accumulates in Maple Syrup Urine Disease (MSUD) and shown to compromise brain energy metabolism by blocking the respiratory chain. Number of Targets: 0 |
| T3D3769 | Kojic acid 501-30-4 | C6H6O4 142.109 g/mol |  |
| Kojic acid acts as a competitive and reversible inhibitor of animal and plant polyphenol oxidases (tyrosinases), xanthine oxidase, and D- and some L-amino acid oxidase...more Number of Targets: 4 |
| T3D2519 | Kurtoxin 820959-57-7 | Not Available 7394.400 g/mol |  |
| Kurtoxin affects the gating of voltage-gated sodium channels and calcium channels. In calcium channels Kurtoxin binds close to the channel voltage sensor and thereby p...more Number of Targets: 14 |
| T3D4160 | Kynurenic acid 492-27-3 | C10H7NO3 189.168 g/mol |  |
| Uremic toxins such as kynurenic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can st...more Number of Targets: 6 |
| T3D4247 | L-2-Hydroxyglutaric acid 13095-48-2 | C5H8O5 148.114 g/mol |  |
| 2-hydroxyglutarate is an oncometabolite. It is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET f...more Number of Targets: 16 |
| T3D4320 | L-Alanine 56-41-7 | C3H7NO2 89.093 g/mol |  |
| L-Alanine is a non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar...more Number of Targets: 13 |
| T3D4289 | L-Arginine 74-79-3 | C6H14N4O2 174.201 g/mol |  |
| Many of supplemental L-arginine's activities, including its possible anti-atherogenic actions, may be accounted for by its role as the precursor to nitric oxide or NO....more Number of Targets: 9 |
| T3D4362 | L-Asparagine 70-47-3 | C4H8N2O3 132.118 g/mol |  |
| Asparagine, a non-essential amino acid is important in the metabolism of toxic ammonia in the body through the action of asparagine synthase which attaches ammonia to ...more Number of Targets: 6 |
| T3D2832 | L-Carnitine 541-15-1 | C7H15NO3 161.199 g/mol |  |
| Levocarnitine can be synthesised within the body from the amino acids lysine or methionine. Vitamin C (ascorbic acid) is essential to the synthesis of carnitine. Levoc...more Number of Targets: 12 |