Browsing Toxins
Displaying toxin 2426 - 2450 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3018 | Rifapentine 61379-65-5 | C47H64N4O12 877.031 g/mol |  |
| Rifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifape...more Number of Targets: 0 |
| T3D3019 | Levetiracetam 102767-28-2 | C8H14N2O2 170.209 g/mol |  |
| The precise mechanism(s) by which levetiracetam exerts its antiepileptic effect is unknown. The antiepileptic activity of levetiracetam was assessed in a number of ani...more Number of Targets: 5 |
| T3D3020 | Mitoxantrone 65271-80-9 | C22H28N4O6 444.481 g/mol |  |
| Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also ...more Number of Targets: 12 |
| T3D3021 | Ridogrel 110140-89-1 | C18H17F3N2O3 366.334 g/mol |  |
| Ridogrel inhibits thromboxane A2 synthase and also blocks the thromboxane A2/prostaglandin endoperoxide receptors.
Thromboxane synthetase produces thromboxane in plate...more Number of Targets: 3 |
| T3D3023 | Estazolam 29975-16-4 | C16H11ClN4 294.738 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As ...more Number of Targets: 18 |
| T3D3025 | Ketamine 6740-88-1 | C13H16ClNO 237.725 g/mol |  |
| Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some...more Number of Targets: 12 |
| T3D3027 | Levomethadyl Acetate 1477-40-3 | C23H31NO2 353.498 g/mol |  |
| Opiate receptors (Mu, Kappa, Delta) are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins ...more Number of Targets: 3 |
| T3D3028 | L-Dopa 59-92-7 | C9H11NO4 197.188 g/mol |  |
| Striatal dopamine levels in symptomatic Parkinson's disease are decreased by 60 to 80%, striatal dopaminergic neurotransmission may be enhanced by exogenous supplement...more Number of Targets: 8 |
| T3D3029 | Sevoflurane 28523-86-6 | C4H3F7O 200.055 g/mol |  |
| Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflura...more Number of Targets: 8 |
| T3D3030 | Bromodiphenhydramine 118-23-0 | C17H20BrNO 334.251 g/mol |  |
| Bromodiphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction o...more Number of Targets: 1 |
| T3D3031 | Chlorprothixene 113-59-7 | C18H18ClNS 315.860 g/mol |  |
| Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is bel...more Number of Targets: 16 |
| T3D3032 | Clomipramine 303-49-1 | C19H23ClN2 314.852 g/mol |  |
| Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine acts preferably as an inh...more Number of Targets: 16 |
| T3D3033 | Isocarboxazid 59-63-2 | C12H13N3O2 231.251 g/mol |  |
| Isocarboxazid works by irreversibly blocking the action of a chemical substance known as monoamine oxidase (MAO) in the nervous system. MAO subtypes A and B are involv...more Number of Targets: 2 |
| T3D3035 | Posaconazole 171228-49-2 | C37H42F2N8O4 700.777 g/mol |  |
| As a triazole antifungal agent, posaconazole exerts its antifungal activity through blockage of the cytochrome P-450 dependent enzyme, sterol 14α-demethylase, in fungi...more Number of Targets: 0 |
| T3D3036 | Fosphenytoin 93390-81-9 | C16H15N2O6P 362.274 g/mol |  |
| Fosphenytoin is a prodrug of phenytoin and accordingly, its anticonvulsant effects are attributable to phenytoin. Phenytoin acts on sodium channels on the neuronal cel...more Number of Targets: 1 |
| T3D3038 | Butethal 77-28-1 | C10H16N2O3 212.246 g/mol |  |
| Butethal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The...more Number of Targets: 10 |
| T3D3039 | Hexobarbital 56-29-1 | C12H16N2O3 236.267 g/mol |  |
| Hexobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open...more Number of Targets: 11 |
| T3D3040 | Ephedrine 299-42-3 | C10H15NO 165.232 g/mol |  |
| Ephedrine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 4 |
| T3D3041 | Methotrimeprazine 60-99-1 | C19H24N2OS 328.472 g/mol |  |
| Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, its binding to 5HT2 receptors may also play ...more Number of Targets: 20 |
| T3D3046 | Fencamfamine 1209-98-9 | C15H21N 215.334 g/mol |  |
| Fencamfamine acts as an indirect dopamine agonist. It releases dopamine by a similar mechanism to amphetamines, but is 10x less potent than dexamphetamine at producing...more Number of Targets: 1 |
| T3D3047 | Flunitrazepam 1622-62-4 | C16H12FN3O3 313.283 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity...more Number of Targets: 21 |
| T3D3048 | Bromazepam 1812-30-2 | C14H10BrN3O 316.153 g/mol |  |
| Bromazepam binds to the GABA receptor GABAA, causing a conformational change and increasing inhibitory effects of GABA. Other neurotransmitters are not influenced. Number of Targets: 21 |
| T3D3049 | Clotiazepam 33671-46-4 | C16H15ClN2OS 318.821 g/mol |  |
| Clotiazepam acts at the benzodiazepine receptors (BZD). This agonizes the action of GABA, increasing the frequency of opening of the channel chlorinates and penetratio...more Number of Targets: 18 |
| T3D3051 | Dextroamphetamine 51-64-9 | C9H13N 135.206 g/mol |  |
| The exact mechanism of action is not known. Dextroamphetamine stimulates the release of norepinephrine from central adrenergic receptors. At higher dosages, it causes ...more Number of Targets: 6 |
| T3D3052 | Methamphetamine 537-46-2 | C10H15N 149.233 g/mol |  |
| Methamphetamine enters the brain and triggers a cascading release of norepinephrine, dopamine and serotonin. To a lesser extent methamphetamine acts as a dopaminergic ...more Number of Targets: 14 |