Browsing Toxins
Displaying toxin 2326 - 2350 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2894 | Alfentanil 71195-58-9 | C21H32N6O3 416.517 g/mol |  |
| Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more Number of Targets: 6 |
| T3D2896 | Proparacaine 499-67-2 | C16H26N2O3 294.389 g/mol |  |
| The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that...more Number of Targets: 2 |
| T3D2897 | Biperiden 514-65-8 | C21H29NO 311.461 g/mol |  |
| Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of...more Number of Targets: 5 |
| T3D2898 | Fentanyl 437-38-7 | C22H28N2O 336.471 g/mol |  |
| Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more Number of Targets: 5 |
| T3D2899 | Meloxicam 71125-38-7 | C14H13N3O4S2 351.401 g/mol |  |
| Anti-inflammatory effects of meloxicam are believed to be due to inhibition of prostaglandin synthetase (cylooxygenase), leading to the inhibition of prostaglandin syn...more Number of Targets: 2 |
| T3D2900 | Propofol 2078-54-8 | C12H18O 178.271 g/mol |  |
| The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gama-aminobutyric acid (GABA) through GABA-A receptors. Number of Targets: 11 |
| T3D2903 | Diazepam 439-14-5 | C16H13ClN2O 284.740 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors which mediate sleep, affects muscle relaxation, anticonvulsant activity, motor coordination, and memor...more Number of Targets: 24 |
| T3D2904 | Phenmetrazine 134-49-6 | C11H15NO 177.243 g/mol |  |
| Phenmetrazine is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron leading to an increase in the release of these monoamines int...more Number of Targets: 3 |
| T3D2905 | Trifluoperazine 117-89-5 | C21H24F3N3S 407.496 g/mol |  |
| Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is bel...more Number of Targets: 18 |
| T3D2907 | Mifepristone 84371-65-3 | C29H35NO2 429.594 g/mol |  |
| Mifepristone is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholines...more Number of Targets: 23 |
| T3D2908 | Progabide 62666-20-0 | C17H16ClFN2O2 334.773 g/mol |  |
| Progabide binds to both GABAA and GABAB receptors located on the terminals of primary afferent fibers. Binding to GABAA results in an increased affinity of the GABA re...more Number of Targets: 2 |
| T3D2909 | Oxazepam 604-75-1 | C15H11ClN2O2 286.713 g/mol |  |
| Similar to other benzodiazepines, oxazepam exerts its anxiolytic effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA-A receptors through a coo...more Number of Targets: 24 |
| T3D2910 | Donepezil 120014-06-4 | C24H29NO3 379.492 g/mol |  |
| Donepezil is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 4 |
| T3D2911 | Nalbuphine 20594-83-6 | C21H27NO4 357.443 g/mol |  |
| Receptor studies show that nalbuphine exerts its action via binding to mu, kappa, and delta receptors, but not to sigma receptors. Nalbuphine is primarily a kappa agon...more Number of Targets: 3 |
| T3D2913 | Perphenazine 58-39-9 | C21H26ClN3OS 403.969 g/mol |  |
| Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamin...more Number of Targets: 13 |
| T3D2914 | Levorphanol 77-07-6 | C17H23NO 257.371 g/mol |  |
| Like other mu-agonist opioids it is believed to act at receptors in the periventricular and periaqueductal gray matter in both the brain and spinal cord to alter the t...more Number of Targets: 3 |
| T3D2917 | Drostanolone 58-19-5 | C20H32O2 304.467 g/mol |  |
| Dromostanolone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic ...more Number of Targets: 4 |
| T3D2918 | Diflunisal 22494-42-4 | C13H8F2O3 250.198 g/mol |  |
| The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prosta...more Number of Targets: 7 |
| T3D2919 | Benzphetamine 156-08-1 | C17H21N 239.355 g/mol |  |
| Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological ef...more Number of Targets: 5 |
| T3D2920 | Flupenthixol 2709-56-0 | C23H27F3N2OS 436.533 g/mol |  |
| Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 an...more Number of Targets: 8 |
| T3D2921 | Sirolimus 53123-88-9 | C51H79NO13 914.172 g/mol |  |
| Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mec...more Number of Targets: 4 |
| T3D2924 | Methdilazine 1982-37-2 | C18H20N2S 296.430 g/mol |  |
| Methdilazine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms ...more Number of Targets: 1 |
| T3D2925 | Ondansetron 99614-02-5 | C18H19N3O 293.363 g/mol |  |
| Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present ...more Number of Targets: 15 |
| T3D2926 | Tiagabine 115103-54-3 | C20H25NO2S2 375.548 g/mol |  |
| Though the exact mechanism by which Tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. Number of Targets: 4 |
| T3D2927 | Cocaine 50-36-2 | C17H21NO4 303.353 g/mol |  |
| Cocaine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by reversibly binding to and ina...more Number of Targets: 15 |