Displaying toxin 2326 - 2350 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D2894Alfentanil
71195-58-9
C21H32N6O3
416.517 g/mol
Thumb
  • Amide
  • Amine
  • Analgesic
  • Analgesic, Opioid
  • Anesthetic
  • Anesthetic, Intravenous
  • Drug
  • Ether
  • Metabolite
  • Narcotic
  • Opiate Agonist
  • Organic Compound
  • Synthetic Compound
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more
Number of Targets: 6
T3D2896Proparacaine
499-67-2
C16H26N2O3
294.389 g/mol
Thumb
  • Amine
  • Anesthetic, Local
  • Drug
  • Ester
  • Ether
  • Lachrymator
  • Metabolite
  • Organic Compound
  • Synthetic Compound
The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that...more
Number of Targets: 2
T3D2897Biperiden
514-65-8
C21H29NO
311.461 g/mol
Thumb
  • Amine
  • Antidyskinetic
  • Antiparkinson Agent
  • Drug
  • Metabolite
  • Muscarinic Antagonist
  • Organic Compound
  • Parasympatholytic
  • Synthetic Compound
Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of...more
Number of Targets: 5
T3D2898Fentanyl
437-38-7
C22H28N2O
336.471 g/mol
Thumb
  • Adjuvant
  • Adjuvant, Anesthesia
  • Amide
  • Amine
  • Analgesic
  • Analgesic, Opioid
  • Anesthetic
  • Anesthetic, Intravenous
  • Drug
  • Metabolite
  • Narcotic
  • Opiate Agonist
  • Organic Compound
  • Synthetic Compound
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more
Number of Targets: 5
T3D2899Meloxicam
71125-38-7
C14H13N3O4S2
351.401 g/mol
Thumb
  • Amide
  • Amine
  • Analgesic
  • Anti-Inflammatory Agent, Non-Steroidal
  • Antiemetic
  • Antineoplastic Agent
  • Cyclooxygenase Inhibitor
  • Drug
  • Ester
  • Growth Inhibitor
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Anti-inflammatory effects of meloxicam are believed to be due to inhibition of prostaglandin synthetase (cylooxygenase), leading to the inhibition of prostaglandin syn...more
Number of Targets: 2
T3D2900Propofol
2078-54-8
C12H18O
178.271 g/mol
Thumb
  • Anesthetic, Intravenous
  • Anticonvulsant
  • Antiemetic
  • Drug
  • Free Radical Scavenger
  • Hypnotic and Sedative
  • Metabolite
  • Organic Compound
  • Synthetic Compound
The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gama-aminobutyric acid (GABA) through GABA-A receptors.
Number of Targets: 11
T3D2903Diazepam
439-14-5
C16H13ClN2O
284.740 g/mol
Thumb
  • Adjuvant, Anesthesia
  • Amide
  • Amine
  • Anesthetic, Intravenous
  • Anti-Anxiety Agent
  • Anticonvulsant
  • Antiemetic
  • Drug
  • Food Toxin
  • GABA Modulator
  • Hypnotic and Sedative
  • Metabolite
  • Muscle Relaxant, Central
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Benzodiazepines bind nonspecifically to benzodiazepine receptors which mediate sleep, affects muscle relaxation, anticonvulsant activity, motor coordination, and memor...more
Number of Targets: 24
T3D2904Phenmetrazine
134-49-6
C11H15NO
177.243 g/mol
Thumb
  • Amine
  • Appetite Depressant
  • Central Nervous System Agent
  • Central Nervous System Stimulant
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Sympathomimetic
  • Synthetic Compound
Phenmetrazine is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron leading to an increase in the release of these monoamines int...more
Number of Targets: 3
T3D2905Trifluoperazine
117-89-5
C21H24F3N3S
407.496 g/mol
Thumb
  • Amine
  • Antiemetic
  • Antipsychotic Agent
  • Dopamine Antagonist
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Phenothiazine
  • Synthetic Compound
Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is bel...more
Number of Targets: 18
T3D2907Mifepristone
84371-65-3
C29H35NO2
429.594 g/mol
Thumb
  • Abortifacient Agent, Steroidal
  • Amine
  • Contraceptive, Oral, Synthetic
  • Contraceptive, Postcoital, Synthetic
  • Drug
  • Ester
  • Hormone Antagonist
  • Luteolytic Agent
  • Menstruation-Inducing Agent
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Mifepristone is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholines...more
Number of Targets: 23
T3D2908Progabide
62666-20-0
C17H16ClFN2O2
334.773 g/mol
Thumb
  • Amide
  • Amine
  • Anticonvulsant
  • Antidepressant
  • Antidepressive Agent
  • Antidyskinetic
  • Antiparkinson Agent
  • Drug
  • Ester
  • GABA Agonist
  • Ketone
  • Metabolite
  • Organic Compound
  • Organochloride
  • Organofluoride
  • Synthetic Compound
Progabide binds to both GABAA and GABAB receptors located on the terminals of primary afferent fibers. Binding to GABAA results in an increased affinity of the GABA re...more
Number of Targets: 2
T3D2909Oxazepam
604-75-1
C15H11ClN2O2
286.713 g/mol
Thumb
  • Amide
  • Amine
  • Anti-Anxiety Agent
  • Drug
  • GABA Modulator
  • Hypnotic and Sedative
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Similar to other benzodiazepines, oxazepam exerts its anxiolytic effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA-A receptors through a coo...more
Number of Targets: 24
T3D2910Donepezil
120014-06-4
C24H29NO3
379.492 g/mol
Thumb
  • Amine
  • Cholinesterase Inhibitor
  • Drug
  • Ester
  • Ether
  • Food Toxin
  • Metabolite
  • Nootropic Agent
  • Organic Compound
  • Parasympathomimetic
  • Synthetic Compound
Donepezil is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more
Number of Targets: 4
T3D2911Nalbuphine
20594-83-6
C21H27NO4
357.443 g/mol
Thumb
  • Amine
  • Analgesic, Opioid
  • Drug
  • Ether
  • Metabolite
  • Narcotic
  • Narcotic Antagonist
  • Organic Compound
  • Synthetic Compound
Receptor studies show that nalbuphine exerts its action via binding to mu, kappa, and delta receptors, but not to sigma receptors. Nalbuphine is primarily a kappa agon...more
Number of Targets: 3
T3D2913Perphenazine
58-39-9
C21H26ClN3OS
403.969 g/mol
Thumb
  • Amine
  • Antipsychotic Agent
  • Dopamine Antagonist
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Phenothiazine
  • Synthetic Compound
Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamin...more
Number of Targets: 13
T3D2914Levorphanol
77-07-6
C17H23NO
257.371 g/mol
Thumb
  • Amine
  • Analgesic, Opioid
  • Drug
  • Metabolite
  • Narcotic
  • Organic Compound
  • Synthetic Compound
Like other mu-agonist opioids it is believed to act at receptors in the periventricular and periaqueductal gray matter in both the brain and spinal cord to alter the t...more
Number of Targets: 3
T3D2917Drostanolone
58-19-5
C20H32O2
304.467 g/mol
Thumb
  • Anabolic Agent
  • Antineoplastic Agent, Hormonal
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Dromostanolone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic ...more
Number of Targets: 4
T3D2918Diflunisal
22494-42-4
C13H8F2O3
250.198 g/mol
Thumb
  • Anti-Inflammatory Agent, Non-Steroidal
  • Cyclooxygenase Inhibitor
  • Drug
  • Ester
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prosta...more
Number of Targets: 7
T3D2919Benzphetamine
156-08-1
C17H21N
239.355 g/mol
Thumb
  • Adrenergic Agent
  • Adrenergic Uptake Inhibitor
  • Amine
  • Central Nervous System Agent
  • Central Nervous System Stimulant
  • Dopamine Agent
  • Dopamine Uptake Inhibitor
  • Drug
  • Metabolite
  • Organic Compound
  • Sympathomimetic
  • Synthetic Compound
Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological ef...more
Number of Targets: 5
T3D2920Flupenthixol
2709-56-0
C23H27F3N2OS
436.533 g/mol
Thumb
  • Amine
  • Antipsychotic Agent
  • Dopamine Antagonist
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
  • Thioxanthene
Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 an...more
Number of Targets: 8
T3D2921Sirolimus
53123-88-9
C51H79NO13
914.172 g/mol
Thumb
  • Amide
  • Amine
  • Anti-Bacterial Agent
  • Antibiotic, Antineoplastic
  • Antifungal Agent
  • Drug
  • Ester
  • Ether
  • Immunosuppressive Agent
  • Macrolide
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mec...more
Number of Targets: 4
T3D2924Methdilazine
1982-37-2
C18H20N2S
296.430 g/mol
Thumb
  • Amine
  • Drug
  • Ether
  • Histamine Antagonist
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Methdilazine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms ...more
Number of Targets: 1
T3D2925Ondansetron
99614-02-5
C18H19N3O
293.363 g/mol
Thumb
  • Amide
  • Amine
  • Anti-Anxiety Agent
  • Antiemetic
  • Antipruritic
  • Antipsychotic Agent
  • Drug
  • Ester
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Serotonin Antagonist
  • Synthetic Compound
Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present ...more
Number of Targets: 15
T3D2926Tiagabine
115103-54-3
C20H25NO2S2
375.548 g/mol
Thumb
  • Amine
  • Anticonvulsant
  • Drug
  • GABA Agonist
  • Metabolite
  • Neuroprotective Agent
  • Neurotransmitter Uptake Inhibitor
  • Organic Compound
  • Synthetic Compound
Though the exact mechanism by which Tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.
Number of Targets: 4
T3D2927Cocaine
50-36-2
C17H21NO4
303.353 g/mol
Thumb
  • Amine
  • Anesthetic
  • Anesthetic, Local
  • Dopamine Uptake Inhibitor
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
  • Vasoconstrictor Agent
Cocaine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by reversibly binding to and ina...more
Number of Targets: 15
Displaying toxin 2326 - 2350 of 3678 in total