Browsing Toxins
Displaying toxin 2251 - 2275 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2796 | Loratadine 79794-75-5 | C22H23ClN2O2 382.883 g/mol |  |
| Loratadine competes with free histamine and exhibits specific, selective peripheral H1 antagonistic activity. This blocks the action of endogenous histamine, which sub...more Number of Targets: 3 |
| T3D2797 | Imipramine 50-49-7 | C19H24N2 280.407 g/mol |  |
| Imipramine works by inhibiting the neuronal reuptake of the neurotransmitters norepinephrine and serotonin. It binds the sodium-dependent serotonin transporter and sod...more Number of Targets: 34 |
| T3D2798 | Metharbital 50-11-3 | C9H14N2O3 198.219 g/mol |  |
| Metharbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. ...more Number of Targets: 11 |
| T3D2800 | Quinine 130-95-0 | C20H24N2O2 324.417 g/mol |  |
| The theorized mechanism of action for quinine and related anti-malarial drugs is that these drugs are toxic to the malaria parasite. Specifically, the drugs interfere ...more Number of Targets: 3 |
| T3D2801 | delta9-Tetrahydrocannabinol 1972-08-3 | C21H30O2 314.462 g/mol |  |
| The mechanism of action of marinol is not completely understood. It is thought that cannabinoid receptors in neural tissues may mediate the effects of dronabinol and o...more Number of Targets: 3 |
| T3D2802 | Fluoxetine 54910-89-3 | C17H18F3NO 309.326 g/mol |  |
| Fluoxetine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 18 |
| T3D2803 | Methohexital 151-83-7 | C14H18N2O3 262.304 g/mol |  |
| Methohexital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open....more Number of Targets: 1 |
| T3D2804 | Chlordiazepoxide 58-25-3 | C16H14ClN3O 299.755 g/mol |  |
| Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, includin...more Number of Targets: 18 |
| T3D2805 | Duloxetine 136434-34-9 | C18H19NOS 297.415 g/mol |  |
| Duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. Duloxetine has no significant affi...more Number of Targets: 3 |
| T3D2806 | Chlorpromazine 50-53-3 | C17H19ClN2S 318.864 g/mol |  |
| Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsych...more Number of Targets: 40 |
| T3D2807 | Buspirone 36505-84-7 | C21H31N5O2 385.503 g/mol |  |
| Buspirone binds to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus inhibiting the firi...more Number of Targets: 10 |
| T3D2808 | Entacapone 130929-57-6 | C14H15N3O5 305.286 g/mol |  |
| The mechanism of action of entacapone is believed to be through its ability to inhibit COMT in peripheral tissues, altering the plasma pharmacokinetics of levodopa. Wh...more Number of Targets: 1 |
| T3D2809 | Oxycodone 76-42-6 | C18H21NO4 315.364 g/mol |  |
| Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors...more Number of Targets: 5 |
| T3D2810 | Cimetidine 51481-61-9 | C10H16N6S 252.339 g/mol |  |
| Cimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in...more Number of Targets: 5 |
| T3D2813 | Triflupromazine 146-54-3 | C18H19F3N2S 352.417 g/mol |  |
| Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockag...more Number of Targets: 6 |
| T3D2815 | Dextromethorphan 125-71-3 | C18H25NO 271.397 g/mol |  |
| Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 rec...more Number of Targets: 17 |
| T3D2818 | Nortriptyline 72-69-5 | C19H21N 263.377 g/mol |  |
| It is believed that nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at beta-adrenergic receptors. Tricycl...more Number of Targets: 24 |
| T3D2819 | Amoxapine 14028-44-5 | C17H16ClN3O 313.781 g/mol |  |
| Amoxapine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). Number of Targets: 25 |
| T3D2820 | Pyridostigmine 155-97-5 | C9H13N2O2 181.211 g/mol |  |
| Pyridostigmine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholin...more Number of Targets: 2 |
| T3D2822 | Pentostatin 53910-25-1 | C11H16N4O4 268.269 g/mol |  |
| Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have ...more Number of Targets: 1 |
| T3D2823 | Hydroxyzine 68-88-2 | C21H27ClN2O2 374.904 g/mol |  |
| Hydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. T...more Number of Targets: 4 |
| T3D2825 | Benzthiazide 91-33-8 | C15H14ClN3O4S3 431.937 g/mol |  |
| As a diuretic, benzthiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of ...more Number of Targets: 7 |
| T3D2826 | Carbamazepine 298-46-4 | C15H12N2O 236.269 g/mol |  |
| Carbamazepine inhibits sustained repetitive firing by blocking use-dependent sodium channels. Pain relief is believed to be associated with blockade of synaptic transm...more Number of Targets: 14 |
| T3D2829 | Clonidine 4205-90-7 | C9H9Cl2N3 230.094 g/mol |  |
| Clonidine acts as an agonist at presynaptic alpha(2)-receptors in the nucleus tractus solitarius of the medulla oblongata. Stimulation of these receptors results in th...more Number of Targets: 7 |
| T3D2830 | Mazindol 22232-71-9 | C16H13ClN2O 284.740 g/mol |  |
| Although the mechanism of action of the sympathomimetics in the treatment of obesity is not fully known, these medications have pharmacological effects similar to thos...more Number of Targets: 4 |