Browsing Toxins
Displaying toxin 2201 - 2225 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2720 | Reboxetine 98769-81-4 | C19H23NO3 313.391 g/mol |  |
| Reboxetine is a selective inhibitor of noradrenaline reuptake. It inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethy...more Number of Targets: 1 |
| T3D2721 | Butabarbital 125-40-6 | C10H16N2O3 212.246 g/mol |  |
| Butabarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open....more Number of Targets: 6 |
| T3D2722 | Oxiconazole 64211-46-7 | C18H13Cl4N3O 429.127 g/mol |  |
| Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzy...more Number of Targets: 1 |
| T3D2724 | Benzatropine 86-13-5 | C21H25NO 307.429 g/mol |  |
| Benztropine is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscari...more Number of Targets: 3 |
| T3D2726 | Methysergide 361-37-5 | C21H27N3O2 353.458 g/mol |  |
| Ergoline alkaloids have been shown to have the significant affinity towards the 5-HT1 and 5-HT2 serotonin receptors, D1 and D2 dopamine receptors, and alpha-adrenergic...more Number of Targets: 11 |
| T3D2727 | Cabergoline 81409-90-7 | C26H37N5O2 451.604 g/mol |  |
| Ergoline alkaloids have been shown to have the significant affinity towards the 5-HT1 and 5-HT2 serotonin receptors, D1 and D2 dopamine receptors, and alpha-adrenergic...more Number of Targets: 23 |
| T3D2728 | Phenytoin 57-41-0 | C15H12N2O2 252.268 g/mol |  |
| Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux f...more Number of Targets: 10 |
| T3D2729 | Clotrimazole 23593-75-1 | C22H17ClN2 344.837 g/mol |  |
| Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. In this w...more Number of Targets: 22 |
| T3D2731 | Ropinirole 91374-21-9 | C16H24N2O 260.375 g/mol |  |
| Ropinirole binds the dopamine receptors D3 and D2. Although the precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, it is beli...more Number of Targets: 18 |
| T3D2733 | Topiramate 97240-79-4 | C12H21NO8S 339.362 g/mol |  |
| The precise mechanism of action of topiramate is not known. However, studies have shown that topiramate blocks the action potentials elicited repetitively by a sustain...more Number of Targets: 9 |
| T3D2735 | Lidocaine 137-58-6 | C14H22N2O 234.337 g/mol |  |
| Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic act...more Number of Targets: 10 |
| T3D2736 | Venlafaxine 93413-69-5 | C17H27NO2 277.402 g/mol |  |
| The exact mechanism of action of venlafaxine is unknown, but appears to be associated with the its potentiation of neurotrasmitter activity in the CNS. Venlafaxine and...more Number of Targets: 19 |
| T3D2737 | Atomoxetine 82248-59-7 | C17H21NO 255.355 g/mol |  |
| The precise mechanism by which atomoxetine produces its therapeutic effects in Attention-Deficit/Hyperactivity Disorder (ADHD) is unknown, but is thought to be related...more Number of Targets: 6 |
| T3D2738 | Bleomycin 11056-06-7 | C55H84N17O21S3 1415.551 g/mol |  |
| It has been suggested that bleomycin induces sensitivity to oxygen toxicity and recent studies support the role of the proinflammatory cytokines IL-18 and IL-1beta in ...more Number of Targets: 4 |
| T3D2740 | Morphine 57-27-2 | C17H19NO3 285.338 g/mol |  |
| The precise mechanism of the analgesic action of morphine is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the express...more Number of Targets: 10 |
| T3D2741 | Ropivacaine 84057-95-4 | C17H26N2O 274.401 g/mol |  |
| Local anesthetics such as Ropivacaine block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in th...more Number of Targets: 1 |
| T3D2742 | Bupivacaine 2180-92-9 | C18H28N2O 288.428 g/mol |  |
| Bupivacaine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinest...more Number of Targets: 2 |
| T3D2743 | Mitomycin 50-07-7 | C15H18N4O5 334.327 g/mol |  |
| Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function...more Number of Targets: 1 |
| T3D2745 | Pentobarbital 76-74-4 | C11H18N2O3 226.272 g/mol |  |
| Pentobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open...more Number of Targets: 16 |
| T3D2748 | Zolmitriptan 139264-17-8 | C16H21N3O2 287.357 g/mol |  |
| Zolmitriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blood vessel constriction. Current theories proposed to explain the etiol...more Number of Targets: 5 |
| T3D2749 | Codeine 76-57-3 | C18H21NO3 299.364 g/mol |  |
| Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more Number of Targets: 5 |
| T3D2750 | Dihydroergotamine 6190-39-2 | C33H37N5O5 583.677 g/mol |  |
| Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessel...more Number of Targets: 12 |
| T3D2751 | Tolcapone 134308-13-7 | C14H11NO5 273.241 g/mol |  |
| Tolcapone hepatoxicity can be attributed to elevated levels of transminases, but studies have shown that minimal risk exists for those without preexisting liver condit...more Number of Targets: 1 |
| T3D2752 | Hydromorphone 466-99-9 | C17H19NO3 285.338 g/mol |  |
| Hydromorphone is a narcotic analgesic; its principal therapeutic effect is relief of pain. Hydromorphone interacts predominantly with the opioid mu-receptors. These mu...more Number of Targets: 3 |
| T3D2753 | Indomethacin 53-86-1 | C19H16ClNO4 357.788 g/mol |  |
| Antiinflammatory effects of Indomethacin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Ant...more Number of Targets: 29 |