Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0215 | Chromic acid 7738-94-5 | CrH2O4 118.010 g/mol |  |
| Chromic acid is highly corrosive and strongly oxidative. Many strong acids cause tissue burns through the denaturation of proteins and partial hydrolysis of proteins....more Number of Targets: 5 |
| T3D0216 | Nitrate 14797-55-8 | NO3 62.005 g/mol |  |
| Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and met...more Number of Targets: 16 |
| T3D0217 | Potassium-40 13966-00-2 | K 39.964 g/mol |  |
| The ionizing radiation produced by potassium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal c...more Number of Targets: 1 |
| T3D0219 | Antimony 7440-36-0 | Sb 121.760 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D0221 | Thorium-227 15623-47-9 | Th 227.028 g/mol |  |
| The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal cha...more Number of Targets: 1 |
| T3D0222 | 2,4,5-Trichlorophenol 95-95-4 | C6H3Cl3O 197.446 g/mol |  |
| 2,4,5-Trichlorophenol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acety...more Number of Targets: 6 |
| T3D0223 | Arsenate 15584-04-00 | AsH3O4 141.943 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase. By compe...more Number of Targets: 44 |
| T3D0224 | Arsenic trioxide 1327-53-3 | As2O3 197.841 g/mol |  |
| The mechanism of action of Arsenic Trioxide is not completely understood. Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptos...more Number of Targets: 51 |
| T3D0225 | Phorate 298-02-2 | C7H17O2PS3 260.377 g/mol |  |
| Phorate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesteras...more Number of Targets: 5 |
| T3D0226 | Benzo[e]pyrene 192-97-2 | C20H12 252.309 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D0229 | Dimethoate 60-51-5 | C5H12NO3PS2 229.257 g/mol |  |
| Dimethoate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 10 |
| T3D0230 | Actinium-227 14952-40-0 | Ac 227.028 g/mol |  |
| The ionizing radiation produced by actinium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal ch...more Number of Targets: 1 |
| T3D0232 | 4-Aminobiphenyl 92-67-1 | C12H11N 169.222 g/mol |  |
| 4-Aminobiphenyl requires metabolic activation in order to exert its toxicity. This is catalyzed by N-hydroxylation via cytochrome P450 1A2, then followed by O-sulfatio...more Number of Targets: 2 |
| T3D0233 | Pyrethrum 8003-34-7 | C22H28O5 372.455 g/mol |  |
| Both type I and type II pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to th...more Number of Targets: 20 |
| T3D0234 | Arsine 7784-42-1 | AsH3 77.945 g/mol |  |
| Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic...more Number of Targets: 10 |
| T3D0235 | (±)-Naled 300-76-5 | C4H7Br2Cl2O4P 380.784 g/mol |  |
| (±)-Naled is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 11 |
| T3D0237 | Ethoprop 13194-48-4 | C8H19O2PS2 242.339 g/mol |  |
| Ethoprop is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 8 |
| T3D0240 | Dichlorvos 62-73-7 | C4H7Cl2O4P 220.976 g/mol |  |
| Dichlorvos is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 7 |
| T3D0241 | Calcium arsenate 7778-44-1 | As2Ca3O8 398.072 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0242 | Mercuric chloride 7487-94-7 | Cl2Hg 271.500 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 87 |
| T3D0243 | Sodium arsenite 7784-46-5 | AsNaO2 129.910 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0244 | Formaldehyde 50-00-0 | CH2O 30.026 g/mol |  |
| It is likely that formaldehyde toxicity occurs when intracellular levels saturate formaldehyde dehydrogenase activity, allowing the unmetabolized intact molecule to ex...more Number of Targets: 3 |
| T3D0245 | 2-Chlorophenol 95-57-8 | C6H5ClO 128.556 g/mol |  |
| 2-chlorophenol works as a weak uncoupler of oxidative phosphorylation and inhibitors of cellular respiration. The ability of chlorophenols to uncouple oxidative phosph...more Number of Targets: 5 |
| T3D0246 | Phenanthrene 85-01-8 | C14H10 178.229 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 6 |
| T3D0247 | Hydrogen fluoride 7664-39-3 | FH 20.006 g/mol |  |
| In addition to being a highly corrosive liquid, hydrofluoric acid is also a contact poison. As with most acids HF can cause tissue burns through the denaturation of pr...more Number of Targets: 7 |