Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0058 | m-Xylene 108-38-3 | C8H10 106.165 g/mol |  |
| m-Xylene is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 5 |
| T3D0059 | cis-Chlordane 5103-71-9 | C10H6Cl8 409.779 g/mol |  |
| Chlordane is believed to bind irreversibly to DNA, leading to cell death or altered cellular function. It also affects transcription by antagonizing estrogen-related r...more Number of Targets: 14 |
| T3D0061 | Methoxychlor 72-43-5 | C16H15Cl3O2 345.648 g/mol |  |
| Certain mono- and bis-hydroxy metabolites of methoxychlor, especially 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane (HPTE), act as estrogen analogues. HPTE is an est...more Number of Targets: 51 |
| T3D0062 | Benzo[k]fluoranthene 207-08-9 | C20H12 252.309 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D0063 | Endrin ketone 53494-70-5 | C12H8Cl6O 380.909 g/mol |  |
| Endrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ch...more Number of Targets: 38 |
| T3D0064 | trans-Chlordane 5103-74-2 | C10H6Cl8 409.779 g/mol |  |
| Chlordane is believed to bind irreversibly to DNA, leading to cell death or altered cellular function. It also affects transcription by antagonizing estrogen-related r...more Number of Targets: 14 |
| T3D0065 | Chromium(VI) oxide 1333-82-0 | CrO3 99.994 g/mol |  |
| Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more Number of Targets: 5 |
| T3D0066 | Methane 74-82-8 | CH4 16.043 g/mol |  |
| Methane is an asphyxiant and displaces oxygen in enclosed spaces. At high enough concentrations, oxygen depletion may cause asphyxiation. Low concentrations of surroun...more Number of Targets: 0 |
| T3D0067 | beta Endosulfan 33213-65-9 | C9H6Cl6O3S 406.925 g/mol |  |
| Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake o...more Number of Targets: 49 |
| T3D0069 | Endrin aldehyde 7421-93-4 | C12H8Cl6O 380.909 g/mol |  |
| Endrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ch...more Number of Targets: 38 |
| T3D0070 | Benzofluoranthene 56832-73-6 | C20H12 252.309 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D0071 | Toluene 108-88-3 | C7H8 92.138 g/mol |  |
| Toluene is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesteras...more Number of Targets: 39 |
| T3D0072 | 2-Oxohexane 591-78-6 | C6H12O 100.159 g/mol |  |
| 2-Hexanone's toxicity is believed to be caused by covalent binding of its metabolites, especially 2,5-hexanedione, with axonal components of nerve tissue and inhibitio...more Number of Targets: 16 |
| T3D0073 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6 | C12H4Cl4O2 321.971 g/mol |  |
| CDDs bind to the aryl hydrocarbon (Ah) receptor and subsequently alter the transcription of several genes (oncogenes, growth factors, receptors, hormones, and drug-met...more Number of Targets: 2 |
| T3D0074 | Zinc 7440-66-6 | Zn 65.408 g/mol |  |
| Excessive zinc intake alters copper and iron absorption, most likely through competitive binding in intestinal mucosal cells. Stomach acid dissolves metallic zinc, pro...more Number of Targets: 28 |
| T3D0075 | Dimethylarsinate 15132-04-4 | C2H7AsO2 137.997 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through different mechanisms. At the level of the citric acid cycle, arsenic inhibits the pyruvate dehydrogenase and...more Number of Targets: 54 |
| T3D0076 | Di(2-ethylhexyl)phthalate 117-81-7 | C24H38O4 390.556 g/mol |  |
| Monoethylhexylphthalate (MEHP), one of the major metabolites of DEHP, induces peroxisome proliferation by activating peroxisome proliferator activated receptors. This ...more Number of Targets: 17 |
| T3D0077 | Chromium 7440-47-3 | Cr 51.993 g/mol |  |
| Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more Number of Targets: 6 |
| T3D0078 | Naphthalene 91-20-3 | C10H8 128.171 g/mol |  |
| PAH's such as naphthalene are transported throughout the body after binding blood proteins such as albumin. Binding to the aryl hydrocarbon receptor or glycine N-methy...more Number of Targets: 12 |
| T3D0079 | 1,1-Dichloroethene 75-35-4 | C2H2Cl2 96.943 g/mol |  |
| 1,1-Dichloroethene toxicity is caused by its reactive metabolites, which include epoxides, acyl chlorides, and halogenated aldehydes generated via oxidation by cytochr...more Number of Targets: 39 |
| T3D0080 | Dichloromethane 1975-09-02 | CH2Cl2 84.933 g/mol |  |
| Methylene chloride targets the lungs, blood system, and nervous system. In the lungs its metabolites damage Clara cells. It is also metabolized into carbon monoxide, w...more Number of Targets: 11 |
| T3D0082 | 2,4,6-Trinitrotoluene 118-96-7 | C7H5N3O6 227.131 g/mol |  |
| 2,4,6-Trinitrotoluene is a competitive inhibitor with respect to NADPH and a noncompetitive inhibitor with respect to L-arginine. It binds to the P450 reductase domain...more Number of Targets: 1 |
| T3D0084 | Hydrazine 302-01-2 | H4N2 32.045 g/mol |  |
| At least two mechanisms of action have been observed. One involves the direct binding of those hydrazines with a free amino group (hydrazine and 1,1-dimethylhydrazine)...more Number of Targets: 0 |
| T3D0085 | 1,2-Dichloroethane 107-06-2 | C2H4Cl2 98.959 g/mol |  |
| 1,2-Dichloroethane is metabolized to 2-chloroacetaldehyde, S-(2-chloroethyl)glutathione by conjugation with glutathione, and to other putative reactive intermediates c...more Number of Targets: 39 |
| T3D0086 | 2,4,6-Trichlorophenol 88-06-2 | C6H3Cl3O 197.446 g/mol |  |
| 2,4,6-Trichlorophenol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acety...more Number of Targets: 40 |