Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0031 | Toxaphene 8001-35-2 | C10H8Cl8 411.795 g/mol |  |
| Toxaphene is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 52 |
| T3D0032 | gamma-Hexachlorocyclohexane 58-89-9 | C6H6Cl6 290.830 g/mol |  |
| Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picro...more Number of Targets: 53 |
| T3D0033 | Tetrachloroethylene 127-18-4 | C2Cl4 165.833 g/mol |  |
| Tetrachloroethylene is believed to affect the central nervous system by altering the fatty acid pattern of brain phospholipids and amino acids, or being incorporated i...more Number of Targets: 38 |
| T3D0034 | Heptachlor 76-44-8 | C10H5Cl7 373.318 g/mol |  |
| Heptachlor is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overstimulati...more Number of Targets: 40 |
| T3D0035 | 1,2-Dibromoethane 106-93-4 | C2H4Br2 187.861 g/mol |  |
| The metabolite 2-bromoacetaldehyde produces liver damage by binding to cellular proteins. S-(2-bromoethyl)glutathione, another metabolite, exerts genotoxic and carcino...more Number of Targets: 5 |
| T3D0036 | beta-Hexachlorocyclohexane 319-85-7 | C6H6Cl6 290.830 g/mol |  |
| Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picro...more Number of Targets: 42 |
| T3D0037 | Acrolein 107-02-8 | C3H4O 56.063 g/mol |  |
| Acrolein rapidly and irreversibly binds to lysine moieties and sulfhydryl groups found on many cellular molecules forming thiol ethers. By this mechanism acrolein can ...more Number of Targets: 29 |
| T3D0038 | Disulfoton 298-04-4 | C8H19O2PS3 274.404 g/mol |  |
| Disulfoton is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 6 |
| T3D0039 | Benzo[a]anthracene 56-55-3 | C18H12 228.288 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 7 |
| T3D0040 | 3,3'-Dichlorobenzidine 91-94-1 | C12H10Cl2N2 253.127 g/mol |  |
| 3,3’-Dichlorobenzidine's mechanism of toxicity derives mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yie...more Number of Targets: 50 |
| T3D0041 | Endrin 72-20-8 | C12H8Cl6O 380.909 g/mol |  |
| Endrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ch...more Number of Targets: 42 |
| T3D0042 | Beryllium 7440-41-7 | Be 9.011 g/mol |  |
| Once in the body, beryllium acts as a hapten and interacts with human leucocyte antigen (HLA) DP presenting cells in the lungs, becoming physically associated with a m...more Number of Targets: 3 |
| T3D0043 | delta-Hexachlorocyclohexane 319-86-8 | C6H6Cl6 290.830 g/mol |  |
| Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picro...more Number of Targets: 42 |
| T3D0044 | 1,2-Dibromo-3-chloropropane 96-12-8 | C3H5Br2Cl 236.333 g/mol |  |
| The initial metabolism of 1,2-dibromo-3-chloropropane to reactive epoxide metabolites that bind to DNA and other macromolecules may be responsible for its hepatotoxici...more Number of Targets: 54 |
| T3D0045 | Pentachlorophenol 87-86-5 | C6HCl5O 266.337 g/mol |  |
| Pentachlorophenol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcho...more Number of Targets: 63 |
| T3D0046 | Heptachlor epoxide 1024-57-3 | C10H5Cl7O 389.317 g/mol |  |
| Heptachlor epoxide is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overs...more Number of Targets: 41 |
| T3D0047 | Carbon tetrachloride 56-23-5 | CCl4 153.823 g/mol |  |
| Unmetabolized carbon tetrachloride, depresses the central nervous system. All other toxic effects of carbon tetrachloride are related to its biotransformation via cyto...more Number of Targets: 40 |
| T3D0048 | Aroclor 1221 11104-28-2 | C12H9Cl 188.653 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |
| T3D0049 | Cobalt 7440-48-4 | Co 58.932 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 38 |
| T3D0050 | O,P'-DDT 789-02-6 | C14H9Cl5 354.486 g/mol |  |
| DDT toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDT reduces potassium transport across the membrane. DDT inhibits inactivati...more Number of Targets: 60 |
| T3D0051 | Aroclor 1016 12674-11-2 | C12H7Cl3 257.543 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |
| T3D0052 | Dibutyl phthalate 84-74-2 | C16H22O4 278.344 g/mol |  |
| The most characteristic effect of di-n-butyl phthalate is testicular atrophy. Di-n-butyl phthalate exposure causes both the release of iron from hemoglobin and/or tran...more Number of Targets: 25 |
| T3D0053 | Nickel 7440-02-0 | Ni 58.692 g/mol |  |
| Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promot...more Number of Targets: 73 |
| T3D0055 | Endosulfan sulfate 1031-07-8 | C9H6Cl6O4S 422.925 g/mol |  |
| Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced ...more Number of Targets: 42 |
| T3D0056 | Diazinon 333-41-5 | C12H21N2O3PS 304.346 g/mol |  |
| Diazinon is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 12 |