Browsing Toxins
Displaying toxin 3051 - 3075 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4071 | Gelsemine 509-15-9 | C20H22N2O2 322.401 g/mol |  |
| Gelsemine has convulsant effects with a similar mechanism of action to strychnine. Strychnine is a neurotoxin which acts as an antagonist of glycine and acetylcholine ...more Number of Targets: 0 |
| T3D4073 | Bicuculline 485-49-4 | C20H17NO6 367.352 g/mol |  |
| The action of bicuculline is primarily on the ionotropic GABAA receptors, which are ligand-gated ion channels concerned chiefly with the passing of chloride ions acros...more Number of Targets: 4 |
| T3D4074 | Coriamyrtin 2571-86-0 | C15H18O5 278.300 g/mol |  |
| Coriamyrtin has inhibitory activity when modulating receptors of the central nervous system. In other words, coriamyrtin, as a picrotoxin-like sesquiterpene lactones f...more Number of Targets: 0 |
| T3D4078 | Lasiocarpine 303-34-4 | C21H33NO7 411.489 g/mol |  |
| Lasiocarpine is toxic to liver cells but not to lung cells, which is unable to metabolize the pyrrolizidine alkaloids to pyrroles. The application of lasiocarpine to h...more Number of Targets: 0 |
| T3D4080 | Dictamnine 484-29-7 | C12H9NO2 199.205 g/mol |  |
| Dictamnine has been shown to be phototoxic to human cell lines (namely Jurkat T cells and HaCaT keratinocytes). Although it is less phototoxic than the structurally re...more Number of Targets: 0 |
| T3D4081 | Matrine 519-02-8 | C15H24N2O 248.364 g/mol |  |
| The nervous system is the main target organ by the toxicity of matrine. Morphological observation revealed degenerative changes of the nerve cells in the brain tissue ...more Number of Targets: 0 |
| T3D4082 | Cyclopamine 4449-51-8 | C27H41NO2 411.620 g/mol |  |
| Cyclopamine causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single e...more Number of Targets: 2 |
| T3D4083 | Jervine 469-59-0 | C27H39NO3 425.604 g/mol |  |
| Jervine's biological activity is mediated via its interaction with the 7 pass trans membrane protein smoothened. Jervine binds with and inhibits smoothened, which is a...more Number of Targets: 3 |
| T3D4084 | Veratramine 60-70-8 | C27H39NO2 409.604 g/mol |  |
| Veratramine produces a characteristic excitatory action on the central nervous system, producing both tremor and a characteristic "struggling" behavior. This behaviora...more Number of Targets: 0 |
| T3D4086 | Chelerythrine 34316-15-9 | C21H18NO4 348.371 g/mol |  |
| Chelerythrine is a potent, selective, and cell-permeable protein kinase C (PKC) inhibitor. It is also the major active natural product found in the plant Zanthoxylum c...more Number of Targets: 0 |
| T3D4087 | Chelidonine 476-32-4 | C20H19NO5 353.369 g/mol |  |
| Chelidonine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinest...more Number of Targets: 0 |
| T3D4088 | Lyngbyatoxin A 70497-14-2 | C27H39N3O2 437.618 g/mol |  |
| Lyngbyatoxin A is a tumor promoter. Lyngbyatoxin A and related compounds bind to the cysteine-rich C1 domains (C1A and C1B) of protein kinase C (PKC) isozymes to activ...more Number of Targets: 2 |
| T3D4092 | Dicentrine 517-66-8 | C20H21NO4 339.385 g/mol |  |
| Dicentrine was found to be a potent alpha 1-adrenoceptor blocking agent in rat thoracic aorta as revealed by its competitive antagonism of noradrenaline- (pA2 = 8.19 +...more Number of Targets: 2 |
| T3D4103 | Nantenine 2565-01-7 | C20H21NO4 339.385 g/mol |  |
| Nantenine is an antagonist at both the α1 adrenergic receptor and the 5-HT2A serotonin receptor, and blocks both the behavioural and physiological effects of MDMA in a...more Number of Targets: 37 |
| T3D4113 | Aristolochic acid 313-67-7 | C17H11NO7 341.272 g/mol |  |
| The carcinogenic and mutagenic effects associated with the binding of metabolites of ingested aristolochic acid (AA) to DNA have been extensively described in vitro an...more Number of Targets: 1 |
| T3D4124 | Anatoxin a 64285-06-9 | C10H15NO 165.232 g/mol |  |
| Anatoxin-a is an agonist of both neuronal α4β2 and α4 nicotinic acetylcholine receptors present in the CNS as well as the α12βγδ muscle-type nAchRs that are present at...more Number of Targets: 1 |
| T3D4128 | Brevetoxin B 79580-28-2 | C50H70O14 895.082 g/mol |  |
| Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness c...more Number of Targets: 1 |
| T3D4138 | Anatoxin-a(s) 103170-78-1 | C7H17N4O4P 252.208 g/mol |  |
| Anatoxin-a(s) is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholine...more Number of Targets: 0 |
| T3D4148 | Dimethylamine 124-40-3 | C2H7N 45.084 g/mol |  |
| Uremic toxins such as dimethylamine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can sti...more Number of Targets: 5 |
| T3D4149 | Guanidoacetic acid 352-97-6 | C3H7N3O2 117.107 g/mol |  |
| Uremic toxins such as guanidinoacetic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins ...more Number of Targets: 6 |
| T3D4150 | Hypoxanthine 68-94-0 | C5H4N4O 136.112 g/mol |  |
| Hypoxanthine is a poorly soluble compound. As a result high concentrations of serum hypoxanthine can lead to the formation of kidney stones which can, over the long t...more Number of Targets: 4 |
| T3D4151 | Methylamine 74-89-5 | CH5N 31.057 g/mol |  |
| Uremic toxins such as methylamine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimu...more Number of Targets: 3 |
| T3D4152 | Indoleacetic acid 87-51-4 | C10H9NO2 175.184 g/mol |  |
| Uremic toxins such as indole-3-acetic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins ...more Number of Targets: 7 |
| T3D4153 | Phenylacetic acid 103-82-2 | C8H8O2 136.148 g/mol |  |
| Uremic toxins such as phenylacetic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can...more Number of Targets: 5 |
| T3D4154 | Norepinephrine 51-41-2 | C8H11NO3 169.178 g/mol |  |
| Uremic toxins such as noradrenalin are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stim...more Number of Targets: 19 |