Box jellyfish toxin (Chironex fleckeri) (T3D2649)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesGene RegulationXML
Record Information
Version2.0
Creation Date2009-07-06 21:35:54 UTC
Update Date2014-12-24 20:25:48 UTC
Accession NumberT3D2649
Identification
Common NameBox jellyfish toxin (Chironex fleckeri)
ClassProtein
DescriptionBox jellyfish toxin is found in the venom of the Box jellyfish (class Cubozoa), especially Chironex fleckeri, which is known for its powerful and often fatal sting. (2)
Compound Type
  • Amide
  • Amine
  • Animal Toxin
  • Marine Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Protein StructureNo structure small
Synonyms
Synonym
Box jellyfish toxin
Toxin CfTX-1
Chemical FormulaNot Available
Average Molecular Mass51389.865 g/mol
CAS Registry NumberNot Available
SequenceNot Available
Chemical Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateLiquid
AppearanceClear solution.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility>10 mg/mL
LogPNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Toxicity Profile
Route of ExposureInjection (sting/bite) (3)
Mechanism of ToxicityBox jellyfish toxin has potent hemolytic activity and may act as a pore-forming toxin, disrupting normal transmembrane ion concentration gradients in susceptible cells. (1)
MetabolismFree toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesBox jellyfish toxin is found in the venom of the Box jellyfish (class Cubozoa), especially Chironex fleckeri. (2)
Minimum Risk LevelNot Available
Health EffectsThe box jellyfish venom has multiple effects, attacking the nervous system, heart and skin at the same time.
SymptomsThe box jellyfish sting produces excruciating pain accompanied by an intense burning sensation. (2)
TreatmentBox jellyfish stings should be doused with vinegar, which inhibits and unactivated nematocysts. Rescue breathing and CPR may be required. For less serious stings, treatment with ice packs and antihistamines is an effective method of pain relief. A box jellyfish antivenom does exist, but it must be administered quickly. (2)
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDA7L035
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDNot Available
PDB IDNot Available
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDST3D2649.pdf
General References
  1. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  2. Wikipedia. Chironex fleckeri. Last Updated 19 June 2009. [Link]
  3. Wikipedia. Mollusca. Last Updated 5 August 2009. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available