Pseudechetoxin (T3D2640)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesGene RegulationTargets (2)XML
Targets (2)
Record Information
Version2.0
Creation Date2009-07-06 21:35:46 UTC
Update Date2014-12-24 20:25:48 UTC
Accession NumberT3D2640
Identification
Common NamePseudechetoxin
ClassProtein
DescriptionPseudechetoxin is a peptide toxin produced by the King brown snake (Pseudechis australis). It blocks olfactory and retinal cyclic nucleotide-gated ion channel currents. (2)
Compound Type
  • Amide
  • Amine
  • Animal Toxin
  • Natural Compound
  • Organic Compound
  • Protein
  • Snake Venom
Protein StructureT3d2640
Synonyms
Synonym
CRVP PsTx
Cysteine-rich venom protein pseudechetoxin
Chemical FormulaNot Available
Average Molecular Mass26474.445 g/mol
CAS Registry NumberNot Available
SequenceNot Available
Chemical Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateLiquid
AppearanceClear solution.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility>10 mg/mL
LogPNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Toxicity Profile
Route of ExposureInjection (sting/bite) (4)
Mechanism of ToxicityPseudechetoxin blocks olfactory and retinal cyclic nucleotide-gated (CNG) ion channel currents. It forms high-affinity contacts with the pore turret region and most likely inhibits CNG channel current by blocking the external entrance to the transmembrane pore. (2)
MetabolismFree toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.
Toxicity ValuesLD50: 1.94 mg/kg (Subcutaneous, Mouse) (5) LD50: 0.3 mg/kg (Intravenous, Mouse) (5)
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesPseudechetoxin is a peptide toxin produced by the King brown snake (Pseudechis australis). (2)
Minimum Risk LevelNot Available
Health EffectsPseudechetoxin is a neurotoxinn and affects sensory transduction in the visual and olfactory systems. (2)
SymptomsBites from snakes in the Elapidae family produce pain at the site of the bite, followed by drowsiness, weakness, excessive salivation, decreased blood pressure, difficulty breathing, and paralysis of the facial muscles, lips, tongue, and larynx. In addition, ptosis, blurring of vision, convulsions, and headache may occur. (1)
TreatmentAn antivenom exists for brown snake venom. (3)
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDQ8AVA4
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDNot Available
PDB ID2DDA
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. Dreisbach, RH (1983). Handbook of Poisoning. Los Altos, California: Lange Medical Publications.
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  3. Wikipedia. Antivenom. Last Updated 1 July 2009. [Link]
  4. Wikipedia. Snake venom. Last Updated 25 July 2009. [Link]
  5. Thomas S, Griessel E (1999). LD50 Scores for various snakes. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available

Targets

Target Details
1. Cyclic nucleotide-gated olfactory channel
General Function:
Voltage-gated potassium channel activity
Specific Function:
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
Gene Name:
CNGA2
Uniprot ID:
Q16280
Molecular Weight:
76047.505 Da
References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [15531486 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
Target Details
2. cGMP-gated cation channel alpha-1
General Function:
Voltage-gated potassium channel activity
Specific Function:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Gene Name:
CNGA1
Uniprot ID:
P29973
Molecular Weight:
79584.825 Da
References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [15531486 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.