Shiga toxin subunit A (T3D2609)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesGene RegulationTargets (1)XML
Targets (1)
Record Information
Version2.0
Creation Date2009-07-06 18:11:31 UTC
Update Date2014-12-24 20:25:46 UTC
Accession NumberT3D2609
Identification
Common NameShiga toxin subunit A
ClassProtein
DescriptionShiga toxin, also called verotoxin, is produced by Shigella dysenteriae. Shiga toxins belongs to the family of A-B5 toxins. The A subunit (32,000 molecular weight) is responsible for the toxic action of the protein, and the B subunit (7,700 molecular weight) is responsible for binding to a specific cell type. (2)
Compound Type
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Protein StructureT3d2609
Synonyms
Synonym
StxA
Chemical FormulaNot Available
Average Molecular Mass34813.360 g/mol
CAS Registry NumberNot Available
SequenceNot Available
Chemical Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateLiquid
AppearanceClear solution.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility>10 mg/mL
LogPNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Toxicity Profile
Route of ExposureIngestion (4) ; inhalation (4) ; dermal (4)
Mechanism of ToxicityShiga toxin causes the glycosidase cleavage of ribosomal eucaryotic 28S rRNA, resulting in inhibition of protein synthesis in susceptible cells. (2)
MetabolismFree toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.
Toxicity ValuesLD50: 1.3 ug/mg (Intraperitoneal, Mouse) (1) LD50: 450 ng/kg (Intravenous, Mouse) (1)
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesShiga toxin, also called verotoxin, is produced by Shigella dysenteriae. (2)
Minimum Risk LevelNot Available
Health EffectsShiga toxin is produced by Shigella dysenteriae. Shigella dysenteriae can cause shigellosis (bacillary dysentery). (2, 3)
SymptomsShiga toxin is produced by Shigella dysenteriae. Shigella dysenteriae can cause shigellosis (bacillary dysentery). (2, 3)
TreatmentNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDQ9FBI2
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDShiga toxin subunit A
PDB ID1DM0
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. Gill DM: Bacterial toxins: a table of lethal amounts. Microbiol Rev. 1982 Mar;46(1):86-94. [6806598 ]
  2. Wikipedia. Shiga toxin. Last Updated 27 May 2009. [Link]
  3. Wikipedia. Shigella dysenteriae. Last Updated 29 July 2009. [Link]
  4. Wikipedia. Bacterial toxin. Last Updated 27 February 2009. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available

Targets

1. RNA
References
  1. Wikipedia. Shiga toxin. Last Updated 27 May 2009. [Link]