Mastoparan (Vespa tropica) (T3D2580)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesGene RegulationXML
Record Information
Version2.0
Creation Date2009-07-05 17:25:09 UTC
Update Date2014-12-24 20:25:43 UTC
Accession NumberT3D2580
Identification
Common NameMastoparan (Vespa tropica)
ClassProtein
DescriptionMastoparan is a peptide toxin produced from the venom of the hornet (Vespa analis). (2)
Compound Type
  • Amide
  • Amine
  • Animal Toxin
  • Insect Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Protein StructureT3d2580
Synonyms
Synonym
Mastoparan T
Mastoparan-T
Chemical FormulaNot Available
Average Molecular Mass1625.055 g/mol
CAS Registry Number72093-21-1
SequenceNot Available
Chemical Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateLiquid
AppearanceClear solution.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility>10 mg/mL
LogPNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Toxicity Profile
Route of ExposureInjection (sting/bite) (4)
Mechanism of ToxicityMastoparan causes varying types of exocytosis, depending on its location. In mast cells it causes histamine secretion, while in platelets and chromaffin cells the release serotonin and catecholamines occurs, respectively. Mastoporan activity in the anterior pituitary gland leads to prolactin release. It is believed to stimate the release of these substance by mimicking receptors and activating G proteins. (3, 1)
MetabolismFree toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesMastoparan is a peptide toxin produced from the venom of the hornet (Vespa analis). (2)
Minimum Risk LevelNot Available
Health EffectsMastoparan causes varying types of exocytosis, depending on its location. In mast cells it causes histamine secretion, while in platelets and chromaffin cells the release serotonin and catecholamines occurs, respectively. Mastoporan activity in the anterior pituitary gland leads to prolactin release. (3)
SymptomsHornet stings are painful and may cause allergic reactions in some individuals. (5)
TreatmentNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDP0C1Q6
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDMastoparan
PDB IDNot Available
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDST3D2580.pdf
General References
  1. Higashijima T, Uzu S, Nakajima T, Ross EM: Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins). J Biol Chem. 1988 May 15;263(14):6491-4. [3129426 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  3. Wikipedia. Mastoparan. Last Updated 30 July 2009. [Link]
  4. Wikipedia. Insect toxins. Last Updated 19 February 2009. [Link]
  5. Wikipedia. Hornet. Last Updated 10 August 2009. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available