Record Information
Version2.0
Creation Date2009-06-19 21:58:24 UTC
Update Date2014-12-24 20:23:17 UTC
Accession NumberT3D1177
Identification
Common NameUranyl acetate
ClassSmall Molecule
DescriptionUranyl acetate is a chemical compound of uranium. It is used as a negative stain in electron microscopy. Uranium is a chemical element that has the symbol U and atomic number 92. It is a normal part of rocks, soil, air, and water, and occurs in nature in the form of minerals. (5, 6, 7)
Compound Type
  • Industrial/Workplace Toxin
  • Organic Compound
  • Organometallic
  • Pollutant
  • Radioactive
  • Synthetic Compound
  • Uranium Compound
Chemical Structure
Thumb
Synonyms
Synonym
Bis(acetato)dioxouranium
Bis(acetato-o)dioxouranium
Diacetatodioxouranium
Uranaffin reactant
Uranium acetate
Uranium diacetate dioxide
Uranium oxyacetate
Uranyl acetic acid
Uranyl diacetate
Uranyl(2+) acetate
Chemical FormulaC4H8O6U
Average Molecular Mass390.132 g/mol
Monoisotopic Mass390.083 g/mol
CAS Registry Number541-09-3
IUPAC Namebis(acetic acid); dioxouranium
Traditional Namebis(acetic acid); uranium dioxide
SMILESO=[U]=O.CC(O)=O.CC(O)=O
InChI IdentifierInChI=1S/2C2H4O2.2O.U/c2*1-2(3)4;;;/h2*1H3,(H,3,4);;;
InChI KeyInChIKey=IXSMFXMQHOBORU-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as carboxylic acids. Carboxylic acids are compounds containing a carboxylic acid group with the formula -C(=O)OH.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassCarboxylic acids
Direct ParentCarboxylic acids
Alternative Parents
Substituents
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateSolid
AppearanceYellow crystals.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility100 mg/mL [MERCK INDEX (1996)]
LogPNot Available
Predicted Properties
PropertyValueSource
logP-0.22ChemAxon
pKa (Strongest Acidic)4.54ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area37.3 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity12.64 m³·mol⁻¹ChemAxon
Polarizability5.33 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
SpectraNot Available
Toxicity Profile
Route of ExposureOral (6) ; inhalation (6) ; dermal (6)
Mechanism of ToxicityUranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and proteins in the tubular wall, causing damage. Uranium may also inhibit both sodium transport-dependent and independent ATP utilization and mitochondrial oxidative phosphorylation in the renal proximal tubule. Uranium causes respiratory diseases by damaging alveolar epithelium type II cells in the lungs. Uranium induces c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) activation, which in turn induces tumor necrosis factor alpha (TNF-alpha) secretion and generates and inflammatory response in the lungs. Studies have shown that the more soluble the uranium salt, the more toxic it is. Ionizing radiation produced by uranium damages the DNA, resulting in gene mutations and chromosomal aberrations. This can both both initiate and promote carcinogenesis, and interfere with reproduction and development. (6, 1)
MetabolismUranium is absorbed in low amounts via oral, inhalation, and dermal routes. Uranium in body fluids generally exists as the uranyl ion (UO2)2+ complexed with anions, such as citrate and bicarbonate, or plasma proteins. Uranium preferentially distributes to bone, liver, and kidney. The large majority of uranium that enters the body is not absorbed and is eliminated from the body via the urine and faeces. (5)
Toxicity ValuesLD50: 24 mg/kg (Intraperitoneal, Mouse) (3) LD50: 204 mg/kg (Oral, Rat) (3)
Lethal DoseNot Available
Carcinogenicity (IARC Classification)Uranium: Group 1, carcinogenic to humans (8)
Uses/SourcesUranyl acetate is used as a negative stain in electron microscopy. (7)
Minimum Risk LevelIntermediate Inhalation: 0.0004 mg/m3 (Soluble uranium salts) (4) Chronic Inhalation: 0.0003 mg/m3 (Soluble uranium salts) (4) Intermediate Oral: 0.002 mg/kg/day (Soluble uranium salts) (4) Intermediate Inhalation: 0.008 mg/m3 (Insoluble uranium compounds) (4)
Health EffectsUranium primarily damages the kidney, but may also damage the lungs, central nervous system, and immune system. Uranium's radioactivity is believed to damage the DNA, resulting in carcinogenic effects and reproductive and developmental damage. (5, 6)
SymptomsIngestion of uranium may cause vomiting and diarrhea. (5)
TreatmentNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound ID10915
ChEMBL IDNot Available
ChemSpider ID10453
KEGG IDNot Available
UniProt IDNot Available
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDC005460
Stitch IDUranyl acetate
PDB IDNot Available
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDST3D1177.pdf
General References
  1. Gazin V, Kerdine S, Grillon G, Pallardy M, Raoul H: Uranium induces TNF alpha secretion and MAPK activation in a rat alveolar macrophage cell line. Toxicol Appl Pharmacol. 2004 Jan 1;194(1):49-59. [14728979 ]
  2. Vidaud C, Dedieu A, Basset C, Plantevin S, Dany I, Pible O, Quemeneur E: Screening of human serum proteins for uranium binding. Chem Res Toxicol. 2005 Jun;18(6):946-53. [15962929 ]
  3. Lewis RJ Sr. (ed) (2004). Sax's Dangerous Properties of Industrial Materials. 11th Edition. Hoboken, NJ: Wiley-Interscience, Wiley & Sons, Inc.
  4. ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
  5. Wikipedia. Uranium. Last Updated 28 May 2009. [Link]
  6. ATSDR - Agency for Toxic Substances and Disease Registry (1999). Toxicological profile for uranium. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
  7. Wikipedia. Uranyl acetate. Last Updated 27 April 2009. [Link]
  8. International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. [Link]
Gene Regulation
Up-Regulated Genes
GeneGene SymbolGene IDInteractionChromosomeDetails
Down-Regulated GenesNot Available

Targets

1. DNA
General Function:
Used for biological information storage.
Specific Function:
DNA contains the instructions needed for an organism to develop, survive and reproduce.
Molecular Weight:
2.15 x 1012 Da
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (1999). Toxicological profile for uranium. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]