Record Information |
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Version | 2.0 |
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Creation Date | 2009-06-19 21:58:24 UTC |
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Update Date | 2014-12-24 20:23:17 UTC |
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Accession Number | T3D1177 |
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Identification |
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Common Name | Uranyl acetate |
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Class | Small Molecule |
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Description | Uranyl acetate is a chemical compound of uranium. It is used as a negative stain in electron microscopy. Uranium is a chemical element that has the symbol U and atomic number 92. It is a normal part of rocks, soil, air, and water, and occurs in nature in the form of minerals. (5, 6, 7) |
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Compound Type | - Industrial/Workplace Toxin
- Organic Compound
- Organometallic
- Pollutant
- Radioactive
- Synthetic Compound
- Uranium Compound
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Chemical Structure | |
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Synonyms | Synonym | Bis(acetato)dioxouranium | Bis(acetato-o)dioxouranium | Diacetatodioxouranium | Uranaffin reactant | Uranium acetate | Uranium diacetate dioxide | Uranium oxyacetate | Uranyl acetic acid | Uranyl diacetate | Uranyl(2+) acetate |
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Chemical Formula | C4H8O6U |
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Average Molecular Mass | 390.132 g/mol |
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Monoisotopic Mass | 390.083 g/mol |
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CAS Registry Number | 541-09-3 |
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IUPAC Name | bis(acetic acid); dioxouranium |
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Traditional Name | bis(acetic acid); uranium dioxide |
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SMILES | O=[U]=O.CC(O)=O.CC(O)=O |
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InChI Identifier | InChI=1S/2C2H4O2.2O.U/c2*1-2(3)4;;;/h2*1H3,(H,3,4);;; |
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InChI Key | InChIKey=IXSMFXMQHOBORU-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as carboxylic acids. Carboxylic acids are compounds containing a carboxylic acid group with the formula -C(=O)OH. |
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Kingdom | Organic compounds |
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Super Class | Organic acids and derivatives |
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Class | Carboxylic acids and derivatives |
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Sub Class | Carboxylic acids |
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Direct Parent | Carboxylic acids |
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Alternative Parents | |
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Substituents | - Monocarboxylic acid or derivatives
- Carboxylic acid
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organooxygen compound
- Carbonyl group
- Aliphatic acyclic compound
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Molecular Framework | Not Available |
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External Descriptors | Not Available |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Exogenous |
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Cellular Locations | |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Solid |
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Appearance | Yellow crystals. |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | 100 mg/mL [MERCK INDEX (1996)] | LogP | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Not Available |
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Toxicity Profile |
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Route of Exposure | Oral (6) ; inhalation (6) ; dermal (6) |
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Mechanism of Toxicity | Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and proteins in the tubular wall, causing damage. Uranium may also inhibit both sodium transport-dependent and independent ATP utilization and mitochondrial oxidative phosphorylation in the renal proximal tubule. Uranium causes respiratory diseases by damaging alveolar epithelium type II cells in the lungs. Uranium induces c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) activation, which in turn induces tumor necrosis factor alpha (TNF-alpha) secretion and generates and inflammatory response in the lungs. Studies have shown that the more soluble the uranium salt, the more toxic it is. Ionizing radiation produced by uranium damages the DNA, resulting in gene mutations and chromosomal aberrations. This can both both initiate and promote carcinogenesis, and interfere with reproduction and development. (6, 1) |
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Metabolism | Uranium is absorbed in low amounts via oral, inhalation, and dermal routes. Uranium in body fluids generally exists as the uranyl ion (UO2)2+ complexed with anions, such as citrate and bicarbonate, or plasma proteins. Uranium preferentially distributes to bone, liver, and kidney. The large majority of uranium that enters the body is not absorbed and is eliminated from the body via the urine and faeces. (5) |
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Toxicity Values | LD50: 24 mg/kg (Intraperitoneal, Mouse) (3)
LD50: 204 mg/kg (Oral, Rat) (3) |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Uranium: Group 1, carcinogenic to humans (8) |
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Uses/Sources | Uranyl acetate is used as a negative stain in electron microscopy. (7) |
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Minimum Risk Level | Intermediate Inhalation: 0.0004 mg/m3 (Soluble uranium salts) (4)
Chronic Inhalation: 0.0003 mg/m3 (Soluble uranium salts) (4)
Intermediate Oral: 0.002 mg/kg/day (Soluble uranium salts) (4)
Intermediate Inhalation: 0.008 mg/m3 (Insoluble uranium compounds) (4) |
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Health Effects | Uranium primarily damages the kidney, but may also damage the lungs, central nervous system, and immune system. Uranium's radioactivity is believed to damage the DNA, resulting in carcinogenic effects and reproductive and developmental damage. (5, 6) |
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Symptoms | Ingestion of uranium may cause vomiting and diarrhea. (5) |
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Treatment | Not Available |
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Normal Concentrations |
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| Not Available |
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Abnormal Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | Not Available |
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HMDB ID | Not Available |
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PubChem Compound ID | 10915 |
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ChEMBL ID | Not Available |
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ChemSpider ID | 10453 |
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KEGG ID | Not Available |
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UniProt ID | Not Available |
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OMIM ID | |
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ChEBI ID | Not Available |
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BioCyc ID | Not Available |
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CTD ID | C005460 |
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Stitch ID | Uranyl acetate |
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PDB ID | Not Available |
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ACToR ID | Not Available |
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Wikipedia Link | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | T3D1177.pdf |
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General References | - Gazin V, Kerdine S, Grillon G, Pallardy M, Raoul H: Uranium induces TNF alpha secretion and MAPK activation in a rat alveolar macrophage cell line. Toxicol Appl Pharmacol. 2004 Jan 1;194(1):49-59. [14728979 ]
- Vidaud C, Dedieu A, Basset C, Plantevin S, Dany I, Pible O, Quemeneur E: Screening of human serum proteins for uranium binding. Chem Res Toxicol. 2005 Jun;18(6):946-53. [15962929 ]
- Lewis RJ Sr. (ed) (2004). Sax's Dangerous Properties of Industrial Materials. 11th Edition. Hoboken, NJ: Wiley-Interscience, Wiley & Sons, Inc.
- ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
- Wikipedia. Uranium. Last Updated 28 May 2009. [Link]
- ATSDR - Agency for Toxic Substances and Disease Registry (1999). Toxicological profile for uranium. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
- Wikipedia. Uranyl acetate. Last Updated 27 April 2009. [Link]
- International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. [Link]
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Gene Regulation |
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Up-Regulated Genes | Gene | Gene Symbol | Gene ID | Interaction | Chromosome | Details |
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Down-Regulated Genes | Not Available |
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