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Displaying toxin 3376 - 3400 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D4661Ethyl iodoacetate
623-48-3
C4H7IO2
214.002 g/mol
Thumb
  • Ester
  • Ether
  • Industrial/Workplace Toxin
  • Lachrymator
  • Organic Compound
  • Synthetic Compound
Not Available
Number of Targets: 1
T3D4662Chloracetone
78-95-5
C3H5ClO
92.524 g/mol
Thumb
  • Insecticide
  • Lachrymator
  • Organic Compound
  • Organochloride
  • Pesticide
  • Synthetic Compound
Not Available
Number of Targets: 1
T3D4666Sodium chloride
7647-14-5
ClNa
58.443 g/mol
Thumb
  • Flavouring Agent
  • Food Additive
  • Inorganic Compound
A high salt diet disrupts the natural sodium balance in the body. This causes fluid retention which increases the pressure exerted by the blood against blood vessel wa...more
Number of Targets: 22
T3D4668Estradiol
50-28-2
C18H24O2
272.382 g/mol
Thumb
  • Animal Toxin
  • Anti-Menopausal Agent
  • Contraceptive Agent
  • Drug
  • Estrogen
  • Food Toxin
  • Organic Compound
  • Synthetic Compound
Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has ...more
Number of Targets: 8
T3D46692,4-Toluenediamine
95-80-7
C7H10N2
122.168 g/mol
Thumb
  • Amine
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Pollutant
  • Synthetic Compound
Not Available
Number of Targets: 2
T3D46724,4'-Methylenedianiline
101-77-9
C13H14N2
198.264 g/mol
Thumb
  • Amine
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Pollutant
  • Synthetic Compound
After 4,4'-Methylenedianiline enters to our body, it is transported in the blood or stored in tissues. The N-N-acetylation of the compound leads to the formation of so...more
Number of Targets: 3
T3D4673Adapalene
106685-40-9
C28H28O3
412.520 g/mol
Thumb
  • Anti-Inflammatory Agent, Non-Steroidal
  • Dermatologic Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and retinoid X receptors but does not bind to the cytosolic receptor prot...more
Number of Targets: 6
T3D4674Amsacrine
51264-14-3
C21H19N3O3S
393.459 g/mol
Thumb
  • Amide
  • Antineoplastic Agent
  • Drug
  • Ether
  • Intercalating Agent
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Amsacrine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive...more
Number of Targets: 3
T3D4675Arecoline
63-75-2
C8H13NO2
155.194 g/mol
Thumb
  • Amine
  • Ester
  • Ether
  • Food Toxin
  • Metabolite
  • Natural Compound
  • Nootropic Agent
  • Organic Compound
  • Plant Toxin
Arecoline is the primary active ingredient responsible for the central nervous system effects of the areca nut. Arecoline has been compared to nicotine; however, nicot...more
Number of Targets: 4
T3D4676Azacitidine
320-67-2
C8H12N4O5
244.205 g/mol
Thumb
  • Amine
  • Antimetabolite, Antineoplastic
  • Drug
  • Enzyme Inhibitor
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is thought to induce antineoplastic activity via two mec...more
Number of Targets: 3
T3D4677Azathioprine
446-86-6
C9H7N7O2S
277.263 g/mol
Thumb
  • Antimetabolite
  • Antimetabolite, Antineoplastic
  • Antirheumatic Agent
  • Drug
  • Ether
  • Immunosuppressive Agent
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Azathioprine antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. It may also interfere with cellular metabolism and inhibit mitosis. Its...more
Number of Targets: 1
T3D4681Carmustine
154-93-8
C5H9Cl2N3O2
214.050 g/mol
Thumb
  • Amine
  • Antineoplastic Agent, Alkylating
  • Drug
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Carmustine causes cross-links in DNA and RNA, leading to the inhibition of DNA synthesis, RNA production and RNA translation (protein synthesis). Carmustine also binds...more
Number of Targets: 3
T3D4684Chlorambucil
305-03-3
C14H19Cl2NO2
304.212 g/mol
Thumb
  • Amine
  • Antineoplastic Agent, Alkylating
  • Drug
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their atte...more
Number of Targets: 1
T3D4685Chloromethyl methyl ether
107-30-2
C2H5ClO
80.514 g/mol
Thumb
  • Ether
  • Food Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Organochloride
  • Pollutant
  • Synthetic Compound
Not Available
Number of Targets: 1
T3D4686Cisplatin
15663-27-1
Cl2H4N2Pt
298.035 g/mol
Thumb
  • Antineoplastic Agent
  • Cross-Linking Reagent
  • Drug
  • Inorganic Compound
  • Metabolite
  • Radiation-Sensitizing Agent
  • Synthetic Compound
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their atte...more
Number of Targets: 1
T3D4688Cyclophosphamide
50-18-0
C7H15Cl2N2O2P
261.086 g/mol
Thumb
  • Amide
  • Antineoplastic Agent, Alkylating
  • Antirheumatic Agent
  • Drug
  • Ester
  • Immunosuppressive Agent
  • Metabolite
  • Mutagen
  • Myeloablative Agonist
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their atte...more
Number of Targets: 2
T3D4689Dacarbazine
4342-03-4
C6H10N6O
182.183 g/mol
Thumb
  • Amide
  • Amine
  • Antineoplastic Agent, Alkylating
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by ...more
Number of Targets: 3
T3D4690Dichloroacetic Acid
79-43-6
C2H2Cl2O2
128.942 g/mol
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  • Drug
  • Household Toxin
  • Organic Compound
  • Organochloride
  • Synthetic Compound
The dichloroacetate ion stimulates the activity of the enzyme pyruvate dehydrogenase by inhibiting the enzyme pyruvate dehydrogenase kinase. Thus, it decreases lactate...more
Number of Targets: 1
T3D4693Equilin
474-86-2
C18H20O2
268.350 g/mol
Thumb
  • Drug
  • Organic Compound
  • Synthetic Compound
Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently incre...more
Number of Targets: 6
T3D4695Etoposide
33419-42-0
C29H32O13
588.557 g/mol
Thumb
  • Antineoplastic Agent, Phytogenic
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Etoposide inhibits DNA topoisomerase II, thereby inhibiting DNA re-ligation. This causes critical errors in DNA synthesis at the premitotic stage of cell division and ...more
Number of Targets: 2
T3D4696Griseofulvin
126-07-8
C17H17ClO6
352.766 g/mol
Thumb
  • Anti-Bacterial Agent
  • Antifungal Agent
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis an...more
Number of Targets: 1
T3D4697Iron
7439-89-6
Fe
55.845 g/mol
Thumb
  • Anti-Anemic Agent
  • Drug
  • Food Toxin
  • Household Toxin
  • Inorganic Compound
  • Metabolite
  • Metal
  • Supplement
  • Synthetic Compound
  • Trace Element
Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia.
Number of Targets: 0
T3D4699Isopropyl alcohol
67-63-0
C3H8O
60.095 g/mol
Thumb
  • Disinfectant
  • Food Toxin
  • Household Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Solvent
  • Synthetic Compound
Not Available
Number of Targets: 16
T3D4700Lomustine
13010-47-4
C9H16ClN3O2
233.695 g/mol
Thumb
  • Amine
  • Antineoplastic Agent, Alkylating
  • Drug
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Lomustine is a highly lipophilic nitrosourea compound which undergoes hydrolysis in vivo to form reactive metabolites. These metabolites cause alkylation and cross-lin...more
Number of Targets: 2
T3D4702Melphalan
148-82-3
C13H18Cl2N2O2
305.200 g/mol
Thumb
  • Amine
  • Drug
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases (primarily at the N-7 position of guanine and to a lesser extent, at t...more
Number of Targets: 1
Displaying toxin 3376 - 3400 of 3678 in total