Filter by category:
Displaying toxin 3051 - 3075 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D4071Gelsemine
509-15-9
C20H22N2O2
322.401 g/mol
Thumb
  • Amine
  • Ether
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Gelsemine has convulsant effects with a similar mechanism of action to strychnine. Strychnine is a neurotoxin which acts as an antagonist of glycine and acetylcholine ...more
Number of Targets: 0
T3D4073Bicuculline
485-49-4
C20H17NO6
367.352 g/mol
Thumb
  • Amine
  • Ester
  • Natural Compound
  • Organic Compound
  • Plant Toxin
The action of bicuculline is primarily on the ionotropic GABAA receptors, which are ligand-gated ion channels concerned chiefly with the passing of chloride ions acros...more
Number of Targets: 4
T3D4074Coriamyrtin
2571-86-0
C15H18O5
278.300 g/mol
Thumb
  • Ester
  • Ether
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Coriamyrtin has inhibitory activity when modulating receptors of the central nervous system. In other words, coriamyrtin, as a picrotoxin-like sesquiterpene lactones f...more
Number of Targets: 0
T3D4078Lasiocarpine
303-34-4
C21H33NO7
411.489 g/mol
Thumb
  • Amine
  • Ester
  • Ether
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Lasiocarpine is toxic to liver cells but not to lung cells, which is unable to metabolize the pyrrolizidine alkaloids to pyrroles. The application of lasiocarpine to h...more
Number of Targets: 0
T3D4080Dictamnine
484-29-7
C12H9NO2
199.205 g/mol
Thumb
  • Ether
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Dictamnine has been shown to be phototoxic to human cell lines (namely Jurkat T cells and HaCaT keratinocytes). Although it is less phototoxic than the structurally re...more
Number of Targets: 0
T3D4081Matrine
519-02-8
C15H24N2O
248.364 g/mol
Thumb
  • Amide
  • Amine
  • Natural Compound
  • Organic Compound
  • Plant Toxin
The nervous system is the main target organ by the toxicity of matrine. Morphological observation revealed degenerative changes of the nerve cells in the brain tissue ...more
Number of Targets: 0
T3D4082Cyclopamine
4449-51-8
C27H41NO2
411.620 g/mol
Thumb
  • Amine
  • Ether
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Cyclopamine causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single e...more
Number of Targets: 2
T3D4083Jervine
469-59-0
C27H39NO3
425.604 g/mol
Thumb
  • Amine
  • Ester
  • Ether
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Jervine's biological activity is mediated via its interaction with the 7 pass trans membrane protein smoothened. Jervine binds with and inhibits smoothened, which is a...more
Number of Targets: 3
T3D4084Veratramine
60-70-8
C27H39NO2
409.604 g/mol
Thumb
  • Amine
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Veratramine produces a characteristic excitatory action on the central nervous system, producing both tremor and a characteristic "struggling" behavior. This behaviora...more
Number of Targets: 0
T3D4086Chelerythrine
34316-15-9
C21H18NO4
348.371 g/mol
Thumb
  • Ether
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Chelerythrine is a potent, selective, and cell-permeable protein kinase C (PKC) inhibitor. It is also the major active natural product found in the plant Zanthoxylum c...more
Number of Targets: 0
T3D4087Chelidonine
476-32-4
C20H19NO5
353.369 g/mol
Thumb
  • Amine
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Chelidonine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinest...more
Number of Targets: 0
T3D4088Lyngbyatoxin A
70497-14-2
C27H39N3O2
437.618 g/mol
Thumb
  • Amine
  • Bacterial Toxin
  • Marine Toxin
  • Natural Compound
  • Organic Compound
Lyngbyatoxin A is a tumor promoter. Lyngbyatoxin A and related compounds bind to the cysteine-rich C1 domains (C1A and C1B) of protein kinase C (PKC) isozymes to activ...more
Number of Targets: 2
T3D4092Dicentrine
517-66-8
C20H21NO4
339.385 g/mol
Thumb
  • Amine
  • Ether
  • Food Toxin
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Dicentrine was found to be a potent alpha 1-adrenoceptor blocking agent in rat thoracic aorta as revealed by its competitive antagonism of noradrenaline- (pA2 = 8.19 +...more
Number of Targets: 2
T3D4103Nantenine
2565-01-7
C20H21NO4
339.385 g/mol
Thumb
  • Amine
  • Ether
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Nantenine is an antagonist at both the α1 adrenergic receptor and the 5-HT2A serotonin receptor, and blocks both the behavioural and physiological effects of MDMA in a...more
Number of Targets: 37
T3D4113Aristolochic acid
313-67-7
C17H11NO7
341.272 g/mol
Thumb
  • Ester
  • Ether
  • Natural Compound
  • Organic Compound
  • Plant Toxin
The carcinogenic and mutagenic effects associated with the binding of metabolites of ingested aristolochic acid (AA) to DNA have been extensively described in vitro an...more
Number of Targets: 1
T3D4124Anatoxin a
64285-06-9
C10H15NO
165.232 g/mol
Thumb
  • Amine
  • Bacterial Toxin
  • Ester
  • Natural Compound
  • Organic Compound
Anatoxin-a is an agonist of both neuronal α4β2 and α4 nicotinic acetylcholine receptors present in the CNS as well as the α12βγδ muscle-type nAchRs that are present at...more
Number of Targets: 1
T3D4128Brevetoxin B
79580-28-2
C50H70O14
895.082 g/mol
Thumb
  • Aldehyde
  • Animal Toxin
  • Ester
  • Ether
  • Marine Toxin
  • Natural Compound
  • Organic Compound
Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness c...more
Number of Targets: 1
T3D4138Anatoxin-a(s)
103170-78-1
C7H17N4O4P
252.208 g/mol
Thumb
  • Amide
  • Amine
  • Bacterial Toxin
  • Ester
  • Insecticide
  • Natural Compound
  • Organic Compound
  • Pesticide
Anatoxin-a(s) is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholine...more
Number of Targets: 0
T3D4148Dimethylamine
124-40-3
C2H7N
45.084 g/mol
Thumb
  • Dye
  • Food Toxin
  • Fungicide
  • Household Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Pesticide
  • Uremic Toxin
Uremic toxins such as dimethylamine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can sti...more
Number of Targets: 5
T3D4149Guanidoacetic acid
352-97-6
C3H7N3O2
117.107 g/mol
Thumb
  • Affinity Label
  • Amide
  • Amine
  • Food Toxin
  • Lachrymator
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Uremic Toxin
Uremic toxins such as guanidinoacetic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins ...more
Number of Targets: 6
T3D4150Hypoxanthine
68-94-0
C5H4N4O
136.112 g/mol
Thumb
  • Food Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Uremic Toxin
Hypoxanthine is a poorly soluble compound. As a result high concentrations of serum hypoxanthine can lead to the formation of kidney stones which can, over the long t...more
Number of Targets: 4
T3D4151Methylamine
74-89-5
CH5N
31.057 g/mol
Thumb
  • Food Toxin
  • Household Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Uremic Toxin
Uremic toxins such as methylamine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimu...more
Number of Targets: 3
T3D4152Indoleacetic acid
87-51-4
C10H9NO2
175.184 g/mol
Thumb
  • Food Toxin
  • Industrial/Workplace Toxin
  • Lachrymator
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Uremic Toxin
Uremic toxins such as indole-3-acetic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins ...more
Number of Targets: 7
T3D4153Phenylacetic acid
103-82-2
C8H8O2
136.148 g/mol
Thumb
  • Food Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Uremic Toxin
Uremic toxins such as phenylacetic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can...more
Number of Targets: 5
T3D4154Norepinephrine
51-41-2
C8H11NO3
169.178 g/mol
Thumb
  • Adrenergic alpha-Agonist
  • Amine
  • Drug
  • Food Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Sympathomimetic
  • Uremic Toxin
  • Vasoconstrictor Agent
Uremic toxins such as noradrenalin are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stim...more
Number of Targets: 19
Displaying toxin 3051 - 3075 of 3678 in total