Browsing Toxins By Category
Displaying toxin 3401 - 3425 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4765 | Tolazamide 1156-19-0 | C14H21N3O3S 311.400 g/mol |  |
| Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the...more Number of Targets: 3 |
| T3D2751 | Tolcapone 134308-13-7 | C14H11NO5 273.241 g/mol |  |
| Tolcapone hepatoxicity can be attributed to elevated levels of transminases, but studies have shown that minimal risk exists for those without preexisting liver condit...more Number of Targets: 1 |
| T3D0071 | Toluene 108-88-3 | C7H8 92.138 g/mol |  |
| Toluene is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesteras...more Number of Targets: 39 |
| T3D1665 | Toluene diisocyanate 86-91-9 | C18H12N4O4 348.312 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D1653 | Toluenesulfonylmethyl isocyanide 36635-61-7 | C9H9NO2S 195.238 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D2733 | Topiramate 97240-79-4 | C12H21NO8S 339.362 g/mol |  |
| The precise mechanism of action of topiramate is not known. However, studies have shown that topiramate blocks the action potentials elicited repetitively by a sustain...more Number of Targets: 9 |
| T3D0031 | Toxaphene 8001-35-2 | C10H8Cl8 411.795 g/mol |  |
| Toxaphene is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 52 |
| T3D3099 | Toxiferine 6888-23-9 | C40H46Cl2N4O2 685.725 g/mol |  |
| Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Number of Targets: 16 |
| T3D2597 | Toxin A (Clostridium difficile) Not Available | Not Available 308052.765 g/mol |  |
| Rho GTPases are activated by glucosylation (for example RhoA at Thr37). The toxins catalyze the transfer of a glucosyl moiety from UDP-glucose to the Rho GTPases. The ...more Number of Targets: 20 |
| T3D2598 | Toxin B (Clostridium difficile) Not Available | Not Available 269709.285 g/mol |  |
| Rho GTPases are activated by glucosylation (for example RhoA at Thr37). The toxins catalyze the transfer of a glucosyl moiety from UDP-glucose to the Rho GTPases. The ...more Number of Targets: 20 |
| T3D3714 | Toxin T2 tetrol 34114-99-3 | C15H22O6 298.332 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D3935 | Tralkoxydim 87820-88-0 | C20H27NO3 329.433 g/mol |  |
| Tralkoxydim is structurally a cyclohexanedione, but because it does not appear to produce a toxic metabolite produced by other substances, the EPA has not assumed that...more Number of Targets: 5 |
| T3D1852 | Tralomethrin 66841-25-6 | C22H19Br4NO3 665.007 g/mol |  |
| Pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to the membrane lipid phase i...more Number of Targets: 20 |
| T3D2575 | Tramadol 27203-92-5 | C16H25NO2 263.375 g/mol |  |
| Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both posi...more Number of Targets: 9 |
| T3D0173 | trans-1,2-Dichloroethene 156-60-5 | C2H2Cl2 96.943 g/mol |  |
| Trans-1,2-dichloroethene is a volatile, lipophilic molecule that easily moves through the respiratory and gastrointestinal systems. It has a high affinity for lipids a...more Number of Targets: 4 |
| T3D1907 | trans-1,3-Dichloropropene 10061-02-6 | C3H4Cl2 110.970 g/mol |  |
| The primary toxic effects of trans-1,3-dichloropropene are portal-of-entry effects resulting from the chemical reactivity of the compound and its physicochemical prope...more Number of Targets: 3 |
| T3D0064 | trans-Chlordane 5103-74-2 | C10H6Cl8 409.779 g/mol |  |
| Chlordane is believed to bind irreversibly to DNA, leading to cell death or altered cellular function. It also affects transcription by antagonizing estrogen-related r...more Number of Targets: 14 |
| T3D4889 | trans-Cinnamic acid 140-10-3 | C9H8O2 148.159 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D1586 | trans-Diamminedichloro-palladium(II) 13782-33-7 | Cl2H4N2Pd 209.370 g/mol |  |
| Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, an...more Number of Targets: 6 |
| T3D1588 | trans-Diamminedinitro-palladium(II) 28068-05-5 | H8N4O4Pd 234.510 g/mol |  |
| Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, an...more Number of Targets: 6 |
| T3D1394 | trans-Dichlorobis(ethylenediamine)cobalt(III) chloride 14040-33-6 | C4H16Cl3CoN4 285.489 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D1587 | trans-Dichlorobis-(triphenylphosphine) palladium(II) 965-03-2 | C36H32Cl2P2Pd 703.910 g/mol |  |
| Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, an...more Number of Targets: 6 |
| T3D2881 | Tranylcypromine 155-09-9 | C9H11N 133.190 g/mol |  |
| Tranylcypromine irreversibly and nonselectively inhibits monoamine oxidase (MAO). Within neurons, MAO appears to regulate the levels of monoamines released upon synapt...more Number of Targets: 4 |
| T3D2852 | Trazodone 19794-93-5 | C19H22ClN5O 371.864 g/mol |  |
| Trazodone binds at 5-HT2 receptor, it acts as a serotonin agonist at high doses and a serotonin antagonist at low doses. Like fluoxetine, trazodone's antidepressant ac...more Number of Targets: 15 |
| T3D0793 | Tremolite Asbestos 77536-68-6 | (Na, K)0-1Ca2Mg5Si8O22(OH)2 Not Available |  |
| When asbestos fibers are inhaled, many are deposited on the epithelial surface of the respiratory tree. Fibers that are retained in the lung or mesothelium for long pe...more Number of Targets: 1 |