NF-kappa-B essential modulator

NameNF-kappa-B essential modulator
Synonyms
  • FIP-3
  • FIP3
  • I-kappa-B kinase subunit gamma
  • IkB kinase subunit gamma
  • IkB kinase-associated protein 1
  • IKK-gamma
  • IKKAP1
  • IKKG
  • Inhibitor of nuclear factor kappa-B kinase subunit gamma
  • NEMO
  • NF-kappa-B essential modifier
Gene NameIKBKG
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004702|NF-kappa-B essential modulator
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ
ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE
YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV
LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH
VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
Number of residues419
Molecular Weight48197.35
Theoretical pI5.46
GO Classification
Functions
  • signal transducer activity
  • protein heterodimerization activity
  • ubiquitin protein ligase binding
  • linear polyubiquitin binding
  • protein domain specific binding
  • metal ion binding
  • protein homodimerization activity
Processes
  • MyD88-independent toll-like receptor signaling pathway
  • stimulatory C-type lectin receptor signaling pathway
  • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
  • stress-activated MAPK cascade
  • cell surface receptor signaling pathway
  • nucleotide-binding oligomerization domain containing signaling pathway
  • toll-like receptor 10 signaling pathway
  • regulation of tumor necrosis factor-mediated signaling pathway
  • toll-like receptor 2 signaling pathway
  • activation of NF-kappaB-inducing kinase activity
  • immune response
  • toll-like receptor 3 signaling pathway
  • transcription, DNA-templated
  • activation of MAPK activity
  • inflammatory response
  • toll-like receptor 4 signaling pathway
  • JNK cascade
  • establishment of vesicle localization
  • toll-like receptor 5 signaling pathway
  • T cell receptor signaling pathway
  • toll-like receptor 9 signaling pathway
  • I-kappaB kinase/NF-kappaB signaling
  • toll-like receptor signaling pathway
  • response to virus
  • toll-like receptor TLR1
  • viral process
  • toll-like receptor TLR6
  • tumor necrosis factor-mediated signaling pathway
  • cellular response to DNA damage stimulus
  • TRIF-dependent toll-like receptor signaling pathway
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • innate immune response
  • positive regulation of NF-kappaB transcription factor activity
  • Fc-epsilon receptor signaling pathway
  • negative regulation of neuron death
  • apoptotic process
  • positive regulation of type I interferon production
  • MyD88-dependent toll-like receptor signaling pathway
  • positive regulation of transcription from RNA polymerase II promoter
  • B cell homeostasis
Components
  • intracellular
  • IkappaB kinase complex
  • cytoplasm
  • nucleus
  • ubiquitin ligase complex
  • cytosol
  • spindle pole
  • mitotic spindle
General FunctionUbiquitin protein ligase binding
Specific FunctionRegulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9Y6K9
UniProtKB Entry NameNEMO_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019280|NF-kappa-B essential modulator (IKBKG)
ATGGCCCTTGTGATCCAGGTGGGGAAACTAAGGCCCAGAGAAGTGAGGACCCCGCAGACT
ATCAATCCCAGTCTCTTCCCCTCACTCCCTGTGAAGCTCTCCAGCATCATCGAGGTCCCA
TCAGGTGGGGAAAGATGCTGTTCCAGGCGCACACTAGTCTACAAGGCCAGAGCTTTCTGG
AAGGGGGCACCCTTGCCCTGTTGGATGAATAGGCACCTCTGGAAGAGCCAACTGTGTGAG
ATGGTGCAGCCCAGTGGTGGCCCGGCAGCAGATCAGGACGTACTGGGCGAAGAGTCTCCT
CTGGGGAAGCCAGCCATGCTGCACCTGCCTTCAGAACAGGGCGCTCCTGAGACCCTCCAG
CGCTGCCTGGAGGAGAATCAAGAGCTCCGAGATGCCATCCGGCAGAGCAACCAGATTCTG
CGGGAGCGCTGCGAGGAGCTTCTGCATTTCCAAGCCAGCCAGAGGGAGGAGAAGGAGTTC
CTCATGTGCAAGTTCCAGGAGGCCAGGAAACTGGTGGAGAGACTCGGCCTGGAGAAGCTC
GATCTGAAGAGGCAGAAGGAGCAGGCTCTGCGGGAGGTGGAGCACCTGAAGAGATGCCAG
CAGCAGATGGCTGAGGACAAGGCCTCTGTGAAAGCCCAGGTGACGTCCTTGCTCGGGGAG
CTGCAGGAGAGCCAGAGTCGCTTGGAGGCTGCCACTAAGGAATGCCAGGCTCTGGAGGGT
CGGGCCCGGGCGGCCAGCGAGCAGGCGCGGCAGCTGGAGAGTGAGCGCGAGGCGCTGCAG
CAGCAGCACAGCGTGCAGGTGGACCAGCTGCGCATGCAGGGCCAGAGCGTGGAGGCCGCG
CTCCGCATGGAGCGCCAGGCCGCCTCGGAGGAGAAGAGGAAGCTGGCCCAGTTGCAGGTG
GCCTATCACCAGCTCTTCCAAGAATACGACAACCACATCAAGAGCAGCGTGGTGGGCAGT
GAGCGGAAGCGAGGAATGCAGCTGGAAGATCTCAAACAGCAGCTCCAGCAGGCCGAGGAG
GCCCTGGTGGCCAAACAGGAGGTGATCGATAAGCTGAAGGAGGAGGCCGAGCAGCACAAG
ATTGTGATGGAGACCGTTCCGGTGCTGAAGGCCCAGGCGGATATCTACAAGGCGGACTTC
CAGGCTGAGAGGCAGGCCCGGGAGAAGCTGGCCGAGAAGAAGGAGCTCCTGCAGGAGCAG
CTGGAGCAGCTGCAGAGGGAGTACAGCAAACTGAAGGCCAGCTGTCAGGAGTCGGCCAGG
ATCGAGGACATGAGGAAGCGGCATGTCGAGGTCTCCCAGGCCCCCTTGCCCCCCGCCCCT
GCCTACCTCTCCTCTCCCCTGGCCCTGCCCAGCCAGAGGAGGAGCCCCCCCGAGGAGCCA
CCTGACTTCTGCTGTCCCAAGTGCCAGTATCAGGCCCCTGATATGGACACCCTGCAGATA
CATGTCATGGAGTGCATTGAGTAG
GenBank Gene IDAF062089
GeneCard IDNot Available
GenAtlas IDIKBKG
HGNC IDHGNC:5961
Chromosome LocationX
LocusXq28
References
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