Chloride intracellular channel protein 4

NameChloride intracellular channel protein 4
Synonyms
  • Intracellular chloride ion channel protein p64H1
Gene NameCLIC4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013584|Chloride intracellular channel protein 4
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLK
RKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMD
IFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLD
GNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEV
EIAYSDVAKRLTK
Number of residues253
Molecular Weight28771.8
Theoretical pINot Available
GO Classification
Functions
  • chloride channel activity
  • voltage-gated ion channel activity
Processes
  • chloride transport
  • vacuolar acidification
  • branching morphogenesis of an epithelial tube
  • keratinocyte differentiation
  • cell differentiation
  • multicellular organism growth
  • endothelial cell morphogenesis
  • apoptotic process
  • regulation of cytoskeleton organization
  • angiogenesis
  • chloride transmembrane transport
  • establishment or maintenance of apical/basal cell polarity
  • fertilization
  • cellular response to calcium ion
  • retina vasculature morphogenesis in camera-type eye
  • negative regulation of cell migration
Components
  • apical part of cell
  • cell-cell junction
  • cytoplasmic vesicle membrane
  • plasma membrane
  • cell surface
  • actin cytoskeleton
  • chloride channel complex
  • cytosol
  • extracellular exosome
  • perinuclear region of cytoplasm
  • microvillus
  • centrosome
  • midbody
  • intracellular
  • nuclear matrix
  • cytoplasm
  • mitochondrion
General FunctionVoltage-gated ion channel activity
Specific FunctionCan insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Pfam Domain Function
Transmembrane Regions37-57
GenBank Protein IDNot Available
UniProtKB IDQ9Y696
UniProtKB Entry NameCLIC4_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013585|Chloride intracellular channel protein 4 (CLIC4)
ATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAG
CTCTTCGTCAAGGCTGGCAGTGATGGTGAAAGCATAGGAAACTGCCCCTTTTCCCAGAGG
CTCTTCATGATTCTTTGGCTCAAAGGAGTTGTATTTAGTGTGACGACTGTTGACCTGAAA
AGGAAGCCAGCAGACCTGCAGAACTTGGCTCCCGGGACCCACCCACCATTTATAACTTTC
AACAGTGAAGTCAAAACGGATGTAAATAAGATTGAGGAATTTCTTGAAGAAGTCTTATGC
CCTCCCAAGTACTTAAAGCTTTCACCAAAACACCCAGAATCAAATACTGCTGGAATGGAC
ATCTTTGCCAAATTCTCTGCATATATCAAGAATTCAAGGCCAGAGGCTAATGAAGCACTG
GAGAGGGGTCTCCTGAAAACCCTGCAGAAACTGGATGAATATCTGAATTCTCCTCTCCCT
GATGAAATTGATGAAAATAGTATGGAGGACATAAAGTTTTCTACACGTAAATTTCTGGAT
GGCAATGAAATGACATTAGCTGATTGCAACCTGCTGCCCAAACTGCATATTGTCAAGGTG
GTGGCCAAAAAATATCGCAACTTTGATATTCCAAAAGAAATGACTGGCATCTGGAGATAC
CTAACTAATGCATACAGTAGGGACGAGTTCACCAATACCTGTCCCAGTGATAAGGAGGTT
GAAATAGCATATAGTGATGTAGCCAAAAGACTCACCAAGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:13518
Chromosome Location1
LocusNot Available
References
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