T3DB: Kinesin-like protein KIF3A

Name	Kinesin-like protein KIF3A
Synonyms	KIF3 Microtubule plus end-directed kinesin motor 3A
Gene Name	KIF3A
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009160\|Kinesin-like protein KIF3A MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKT FTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELR GIIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVY IKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMH VRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNS KLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALL RQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKKRRGKKKVSPDKMI EMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVI VGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQ GKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDY QEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKEKDPFEVDLSHVYLAYTEESL RQSLMKLERPRTSKGKARPKTGRRKRSAKPETVIDSLLQ
Number of residues	699
Molecular Weight	80040.19
Theoretical pI	Not Available
GO Classification	Functions ATP-dependent microtubule motor activity, plus-end-directed ATP binding spectrin binding Processes cilium assembly plus-end-directed vesicle transport along microtubule cilium morphogenesis microtubule-based movement blood coagulation membrane organization antigen processing and presentation of exogenous peptide antigen via MHC class II organelle organization Components primary cilium centrosome ciliary tip microtubule cytoskeleton kinesin II complex microtubule cytosol extracellular exosome
General Function	Spectrin binding
Specific Function	Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity).
Pfam Domain Function	Kinesin (PF00225 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	Q9Y496
UniProtKB Entry Name	KIF3A_HUMAN
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0017709\|Kinesin-like protein KIF3A (KIF3A) ATGCCGATCAATAAATCAGAGAAGCCAGAAAGCTGCGATAATGTGAAGGTTGTTGTTAGG TGCCGGCCCCTCAATGAGAGAGAGAAATCAATGTGCTACAAACAGGCTGTCAGTGTGGAT GAGATGAGGGGAACTATCACTGTACATAAGACTGATTCTTCCAATGAACCTCCAAAGACA TTTACTTTTGATACTGTTTTTGGACCAGAGAGTAAACAACTTGATGTTTATAACTTAACT GCAAGACCTATTATTGATTCTGTACTTGAAGGCTACAATGGGACTATTTTTGCATATGGA CAAACCGGAACAGGCAAAACTTTTACCATGGAAGGTGTTCGAGCTATTCCTGAACTTAGA GGAATAATTCCCAATTCATTTGCTCACATATTTGGTCATATTGCAAAAGCGGAGGGTGAT ACAAGATTTTTGGTTCGAGTGTCTTATTTGGAAATATATAATGAAGAAGTTCGTGACCTT TTGGGCAAGGATCAGACACAAAGGTTAGAGGTTAAAGAAAGACCTGATGTGGGAGTTTAT ATCAAAGATTTATCAGCTTATGTGGTAAATAATGCTGATGATATGGATAGAATTATGACG CTAGGCCACAAAAATCGTTCTGTTGGTGCAACTAATATGAACGAACATAGTTCCCGTTCC CATGCCATCTTTACAATTACTATAGAATGCAGTGAAAAAGGCATTGATGGTAACATGCAT GTCAGGATGGGGAAGCTCCATCTTGTAGATCTTGCTGGTTCAGAAAGACAGGCAAAAACT GGAGCTACTGGACAGCGCCTAAAGGAAGCTACAAAAATCAATCTTTCACTTTCCACCCTT GGTAATGTAATTTCTGCCTTGGTTGATGGAAAAAGCACTCATGTGCCTTATCGTAACTCT AAACTGACTCGTCTTCTTCAGGATTCCTTAGGAGGAAATTCAAAAACCATGATGTGTGCA AATATTGGGCCAGCAGATTACAATTATGATGAAACTATCAGTACATTACGGTATGCCAAT CGTGCTAAGAATATTAAAAATAAAGCTAGAATTAATGAAGATCCAAAGGATGCTTTGCTG CGTCAGTTCCAGAAAGAAATAGAAGAACTGAAAAAGAAGCTTGAAGAAGGAGAAGAAATA TCAGGCTCTGATATCAGTGGGTCAGAGGAAGATGATGATGAAGAGGGTGAGGTTGGAGAA GATGGAGAGAAAAGGAAAAAAAGAAGGGGCAGTAGCAGCAGCAGTAGTTCAGACTCCACA TGTTCTGTCATAGAGAAACCTCTGGATAAGTTCTTGCCTAATCAAGCAGGAAAAAAGAAA GTCTCCCCAGACAAGATGATTGAAATGCAAGCAAAAATTGATGAGGAGAGAAAAGCACTT GAAACAAAGCTCGACATGGAAGAAGAAGAAAGAAACAAGGCTAGAGCTGAATTAGAGAAA CGGGAAAAAGATCTTCTTAAAGCCCAACAAGAGCATCAGTCTTTGCTGGAAAAATTATCT GCCCTGGAAAAGAAGGTAATTGTTGGTGGGGTTGACTTGTTGGCCAAAGCTGAGGAACAA GAGAAACTTCTTGAAGAATCTAACATGGAACTGGAAGAAAGGAGGAAAAGAGCAGAGCAA CTTCGCAGAGAACTTGAGGAAAAAGAGCAAGAACGCTTGGATATTGAAGAAAAATATACC AGTTTGCAAGAGGAAGCACAGGGAAAGACCAAGAAGTTAAAGAAAGTTTGGACTATGCTG ATGGCTGCAAAGTCAGAGATGGCTGATCTCCAACAAGAACATCAGAGGGAAATTGAAGGC CTACTGGAGAACATTCGGCAACTTAGCCGGGAGCTTCGACTTCAGATGCTTATTATTGAT AACTTTATACCTCGGGATTATCAGGAAATGATTGAAAACTATGTCCATTGGAATGAAGAC ATAGGAGAATGGCAGCTAAAATGTGTTGCTTATACAGGAAATAACATGAGGAAGCAAACC CCAGTACCTGATAAAAAGGAGAAAGATCCCTTTGAGGTGGACCTTTCTCACGTGTATCTT GCCTATACTGAGGAGAGTCTGCGTCAGTCTTTGATGAAACTAGAAAGACCACGAACTTCA AAGGGGAAAGCAAGGCCAAAGACAGGGAGAAGAAAGCGTTCTGCAAAGCCTGAAACTGTA ATTGACTCTTTACTGCAGTAA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:6319
Chromosome Location	5
Locus	Not Available
References	Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B: Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. Exp Eye Res. 1999 Nov;69(5):491-503. 10548469 Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74. 15372022 Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334 Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. 18669648 Kinzel D, Boldt K, Davis EE, Burtscher I, Trumbach D, Diplas B, Attie-Bitach T, Wurst W, Katsanis N, Ueffing M, Lickert H: Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell. 2010 Jul 20;19(1):66-77. doi: 10.1016/j.devcel.2010.06.005. 20643351 Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. 20068231 Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. 21269460 Uusi-Rauva K, Kyttala A, van der Kant R, Vesa J, Tanhuanpaa K, Neefjes J, Olkkonen VM, Jalanko A: Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. Cell Mol Life Sci. 2012 Jun;69(12):2075-89. doi: 10.1007/s00018-011-0913-1. Epub 2012 Jan 20. 22261744