5'-AMP-activated protein kinase subunit beta-1

Name5'-AMP-activated protein kinase subunit beta-1
Synonyms
  • AMPK
  • AMPK subunit beta-1
Gene NamePRKAB1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0036980|5'-AMP-activated protein kinase subunit beta-1
MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEF
LAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPE
GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS
SSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY
ALSIKDGVMVLSATHRYKKKYVTTLLYKPI
Number of residues270
Molecular Weight30382.085
Theoretical pI6.37
GO Classification
Functions
  • AMP-activated protein kinase activity
  • protein kinase activity
Processes
  • gene expression
  • transcription initiation from RNA polymerase II promoter
  • insulin receptor signaling pathway
  • protein phosphorylation
  • membrane organization
  • organelle organization
  • mitochondrion organization
  • fatty acid biosynthetic process
  • macroautophagy
  • signal transduction
  • positive regulation of gene expression
  • protein heterooligomerization
  • cell cycle arrest
  • regulation of protein kinase activity
Components
  • cytosol
  • nucleotide-activated protein kinase complex
  • nucleus
General FunctionProtein kinase activity
Specific FunctionNon-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID2916800
UniProtKB IDQ9Y478
UniProtKB Entry NameAAKB1_HUMAN
Cellular LocationCytoplasmic
Gene sequence
>lcl|BSEQ0010037|5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)
ATGGGCAATACCAGCAGTGAGCGCGCCGCGCTGGAGCGGCATGGTGGCCATAAGACGCCC
CGGAGGGACAGCTCGGGGGGCACCAAGGACGGGGACAGGCCCAAGATCCTGATGGACAGC
CCCGAAGACGCCGACCTCTTCCACTCCGAGGAAATCAAGGCACCAGAGAAGGAGGAATTC
CTGGCCTGGCAGCATGATCTGGAAGTGAATGATAAAGCTCCCGCCCAGGCTCGGCCAACG
GTGTTTCGATGGACGGGGGGCGGAAAGGAAGTTTACTTATCTGGGTCCTTCAACAACTGG
AGTAAACTTCCCCTCACCAGAAGCCACAATAACTTTGTAGCCATCCTGGATCTGCCGGAA
GGAGAGCATCAGTACAAGTTCTTTGTGGATGGTCAGTGGACGCACGACCCTTCCGAGCCC
ATAGTAACCAGCCAGCTTGGCACAGTTAACAACATCATTCAAGTGAAGAAAACTGACTTT
GAAGTATTTGATGCTTTAATGGTGGATTCCCAAAAGTGCTCCGATGTGTCTGAGCTGTCC
AGTTCTCCCCCAGGACCCTACCATCAGGAGCCCTACGTCTGCAAACCCGAAGAGCGCTTT
CGGGCACCCCCTATTCTCCCCCCACATCTCCTCCAGGTCATCCTGAACAAGGACACGGGG
ATTTCCTGTGATCCAGCTTTGCTTCCTGAGCCCAATCACGTCATGCTGAACCACCTATAC
GCGCTGTCTATCAAGGATGGAGTGATGGTGCTCAGCGCAACCCACCGGTACAAGAAGAAG
TACGTCACCACCTTGTTATACAAGCCCATATGA
GenBank Gene IDAJ224515
GeneCard IDNot Available
GenAtlas IDPRKAB1
HGNC IDHGNC:9378
Chromosome Location12
Locus12q24.1
References
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