Tumor necrosis factor ligand superfamily member 13B

NameTumor necrosis factor ligand superfamily member 13B
Synonyms
  • B lymphocyte stimulator
  • B-cell-activating factor
  • BAFF
  • BLYS
  • Dendritic cell-derived TNF-like molecule
  • TALL-1
  • TALL1
  • TNF- and APOL-related leukocyte expressed ligand 1
  • TNFSF20
  • ZTNF4
Gene NameTNFSF13B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001989|Tumor necrosis factor ligand superfamily member 13B
MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC
LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP
GEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEE
KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL
PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
Number of residues285
Molecular Weight31222.48
Theoretical pI6.15
GO Classification
Functions
  • receptor binding
Processes
  • T cell costimulation
  • tumor necrosis factor-mediated signaling pathway
  • positive regulation of B cell proliferation
  • B cell costimulation
  • B cell homeostasis
  • immunoglobulin secretion
  • signal transduction
  • positive regulation of germinal center formation
  • immune response
  • cell proliferation
  • positive regulation of cell proliferation
  • positive regulation of T cell proliferation
Components
  • cytoplasm
  • extracellular region
  • plasma membrane
  • extracellular space
  • integral component of membrane
  • perinuclear region of cytoplasm
General FunctionReceptor binding
Specific FunctionCytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Pfam Domain Function
Transmembrane Regions47-67
GenBank Protein ID4761612
UniProtKB IDQ9Y275
UniProtKB Entry NameTN13B_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010699|Tumor necrosis factor ligand superfamily member 13B (TNFSF13B)
ATGGATGACTCCACAGAAAGGGAGCAGTCACGCCTTACTTCTTGCCTTAAGAAAAGAGAA
GAAATGAAACTGAAGGAGTGTGTTTCCATCCTCCCACGGAAGGAAAGCCCCTCTGTCCGA
TCCTCCAAAGACGGAAAGCTGCTGGCTGCAACCTTGCTGCTGGCACTGCTGTCTTGCTGC
CTCACGGTGGTGTCTTTCTACCAGGTGGCCGCCCTGCAAGGGGACCTGGCCAGCCTCCGG
GCAGAGCTGCAGGGCCACCACGCGGAGAAGCTGCCAGCAGGAGCAGGAGCCCCCAAGGCC
GGCCTGGAGGAAGCTCCAGCTGTCACCGCGGGACTGAAAATCTTTGAACCACCAGCTCCA
GGAGAAGGCAACTCCAGTCAGAACAGCAGAAATAAGCGTGCCGTTCAGGGTCCAGAAGAA
ACAGGATCTTACACATTTGTTCCATGGCTTCTCAGCTTTAAAAGGGGAAGTGCCCTAGAA
GAAAAAGAGAATAAAATATTGGTCAAAGAAACTGGTTACTTTTTTATATATGGTCAGGTT
TTATATACTGATAAGACCTACGCCATGGGACATCTAATTCAGAGGAAGAAGGTCCATGTC
TTTGGGGATGAATTGAGTCTGGTGACTTTGTTTCGATGTATTCAAAATATGCCTGAAACA
CTACCCAATAATTCCTGCTATTCAGCTGGCATTGCAAAACTGGAAGAAGGAGATGAACTC
CAACTTGCAATACCAAGAGAAAATGCACAAATATCACTGGATGGAGATGTCACATTTTTT
GGTGCATTGAAACTGCTGTGA
GenBank Gene IDAF136293
GeneCard IDNot Available
GenAtlas IDTNFSF13B
HGNC IDHGNC:11929
Chromosome Location13
Locus13q32-34
References
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