Calcium-activated chloride channel regulator 2
Name | Calcium-activated chloride channel regulator 2 |
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Synonyms |
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Gene Name | CLCA2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0019828|Calcium-activated chloride channel regulator 2 MTQRSIAGPICNLKFVTLLVALSSELPFLGAGVQLQDNGYNGLLIAINPQVPENQNLISN IKEMITEASFYLFNATKRRVFFRNIKILIPATWKANNNSKIKQESYEKANVIVTDWYGAH GDDPYTLQYRGCGKEGKYIHFTPNFLLNDNLTAGYGSRGRVFVHEWAHLRWGVFDEYNND KPFYINGQNQIKVTRCSSDITGIFVCEKGPCPQENCIISKLFKEGCTFIYNSTQNATASI MFMQSLSSVVEFCNASTHNQEAPNLQNQMCSLRSAWDVITDSADFHHSFPMNGTELPPPP TFSLVQAGDKVVCLVLDVSSKMAEADRLLQLQQAAEFYLMQIVEIHTFVGIASFDSKGEI RAQLHQINSNDDRKLLVSYLPTTVSAKTDISICSGLKKGFEVVEKLNGKAYGSVMILVTS GDDKLLGNCLPTVLSSGSTIHSIALGSSAAPNLEELSRLTGGLKFFVPDISNSNSMIDAF SRISSGTGDIFQQHIQLESTGENVKPHHQLKNTVTVDNTVGNDTMFLVTWQASGPPEIIL FDPDGRKYYTNNFITNLTFRTASLWIPGTAKPGHWTYTLNNTHHSLQALKVTVTSRASNS AVPPATVEAFVERDSLHFPHPVMIYANVKQGFYPILNATVTATVEPETGDPVTLRLLDDG AGADVIKNDGIYSRYFFSFAANGRYSLKVHVNHSPSISTPAHSIPGSHAMYVPGYTANGN IQMNAPRKSVGRNEEERKWGFSRVSSGGSFSVLGVPAGPHPDVFPPCKIIDLEAVKVEEE LTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFS PQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDY LILKGVLTAMGLIGIICLIIVVTHHTLSRKKRADKKENGTKLL |
Number of residues | 943 |
Molecular Weight | 103940.01 |
Theoretical pI | Not Available |
GO Classification | Functions
Processes
Components
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General Function | Metallopeptidase activity |
Specific Function | Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. |
Pfam Domain Function | |
Transmembrane Regions | 902-922 |
GenBank Protein ID | Not Available |
UniProtKB ID | Q9UQC9 |
UniProtKB Entry Name | CLCA2_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0019829|Calcium-activated chloride channel regulator 2 (CLCA2) ATGACCCAAAGGAGCATTGCAGGTCCTATTTGCAACCTGAAGTTTGTGACTCTCCTGGTT GCCTTAAGTTCAGAACTCCCATTCCTGGGAGCTGGAGTACAGCTTCAAGACAATGGGTAT AATGGATTGCTCATTGCAATTAATCCTCAGGTACCTGAGAATCAGAACCTCATCTCAAAC ATTAAGGAAATGATAACTGAAGCTTCATTTTACCTATTTAATGCTACCAAGAGAAGAGTA TTTTTCAGAAATATAAAGATTTTAATACCTGCCACATGGAAAGCTAATAATAACAGCAAA ATAAAACAAGAATCATATGAAAAGGCAAATGTCATAGTGACTGACTGGTATGGGGCACAT GGAGATGATCCATACACCCTACAATACAGAGGGTGTGGAAAAGAGGGAAAATACATTCAT TTCACACCTAATTTCCTACTGAATGATAACTTAACAGCTGGCTACGGATCACGAGGCCGA GTGTTTGTCCATGAATGGGCCCACCTCCGTTGGGGTGTGTTCGATGAGTATAACAATGAC AAACCTTTCTACATAAATGGGCAAAATCAAATTAAAGTGACAAGGTGTTCATCTGACATC ACAGGCATTTTTGTGTGTGAAAAAGGTCCTTGCCCCCAAGAAAACTGTATTATTAGTAAG CTTTTTAAAGAAGGATGCACCTTTATCTACAATAGCACCCAAAATGCAACTGCATCAATA ATGTTCATGCAAAGTTTATCTTCTGTGGTTGAATTTTGTAATGCAAGTACCCACAACCAA GAAGCACCAAACCTACAGAACCAGATGTGCAGCCTCAGAAGTGCATGGGATGTAATCACA GACTCTGCTGACTTTCACCACAGCTTTCCCATGAATGGGACTGAGCTTCCACCTCCTCCC ACATTCTCGCTTGTACAGGCTGGTGACAAAGTGGTCTGTTTAGTGCTGGATGTGTCCAGC AAGATGGCAGAGGCTGACAGACTCCTTCAACTACAACAAGCCGCAGAATTTTATTTGATG CAGATTGTTGAAATTCATACCTTCGTGGGCATTGCCAGTTTCGACAGCAAAGGAGAGATC AGAGCCCAGCTACACCAAATTAACAGCAATGATGATCGAAAGTTGCTGGTTTCATATCTG CCCACCACTGTATCAGCTAAAACAGACATCAGCATTTGTTCAGGGCTTAAGAAAGGATTT GAGGTGGTTGAAAAACTGAATGGAAAAGCTTATGGCTCTGTGATGATATTAGTGACCAGC GGAGATGATAAGCTTCTTGGCAATTGCTTACCCACTGTGCTCAGCAGTGGTTCAACAATT CACTCCATTGCCCTGGGTTCATCTGCAGCCCCAAATCTGGAGGAATTATCACGTCTTACA GGAGGTTTAAAGTTCTTTGTTCCAGATATATCAAACTCCAATAGCATGATTGATGCTTTC AGTAGAATTTCCTCTGGAACTGGAGACATTTTCCAGCAACATATTCAGCTTGAAAGTACA GGTGAAAATGTCAAACCTCACCATCAATTGAAAAACACAGTGACTGTGGATAATACTGTG GGCAACGACACTATGTTTCTAGTTACGTGGCAGGCCAGTGGTCCTCCTGAGATTATATTA TTTGATCCTGATGGACGAAAATACTACACAAATAATTTTATCACCAATCTAACTTTTCGG ACAGCTAGTCTTTGGATTCCAGGAACAGCTAAGCCTGGGCACTGGACTTACACCCTGAAC AATACCCATCATTCTCTGCAAGCCCTGAAAGTGACAGTGACCTCTCGCGCCTCCAACTCA GCTGTGCCCCCAGCCACTGTGGAAGCCTTTGTGGAAAGAGACAGCCTCCATTTTCCTCAT CCTGTGATGATTTATGCCAATGTGAAACAGGGATTTTATCCCATTCTTAATGCCACTGTC ACTGCCACAGTTGAGCCAGAGACTGGAGATCCTGTTACGCTGAGACTCCTTGATGATGGA GCAGGTGCTGATGTTATAAAAAATGATGGAATTTACTCGAGGTATTTTTTCTCCTTTGCT GCAAATGGTAGATATAGCTTGAAAGTGCATGTCAATCACTCTCCCAGCATAAGCACCCCA GCCCACTCTATTCCAGGGAGTCATGCTATGTATGTACCAGGTTACACAGCAAACGGTAAT ATTCAGATGAATGCTCCAAGGAAATCAGTAGGCAGAAATGAGGAGGAGCGAAAGTGGGGC TTTAGCCGAGTCAGCTCAGGAGGCTCCTTTTCAGTGCTGGGAGTTCCAGCTGGCCCCCAC CCTGATGTGTTTCCACCATGCAAAATTATTGACCTGGAAGCTGTAAAAGTAGAAGAGGAA TTGACCCTATCTTGGACAGCACCTGGAGAAGACTTTGATCAGGGCCAGGCTACAAGCTAT GAAATAAGAATGAGTAAAAGTCTACAGAATATCCAAGATGACTTTAACAATGCTATTTTA GTAAATACATCAAAGCGAAATCCTCAGCAAGCTGGCATCAGGGAGATATTTACGTTCTCA CCCCAAATTTCCACGAATGGACCTGAACATCAGCCAAATGGAGAAACACATGAAAGCCAC AGAATTTATGTTGCAATACGAGCAATGGATAGGAACTCCTTACAGTCTGCTGTATCTAAC ATTGCCCAGGCGCCTCTGTTTATTCCCCCCAATTCTGATCCTGTACCTGCCAGAGATTAT CTTATATTGAAAGGAGTTTTAACAGCAATGGGTTTGATAGGAATCATTTGCCTTATTATA GTTGTGACACATCATACTTTAAGCAGGAAAAAGAGAGCAGACAAGAAAGAGAATGGAACA AAATTATTATAA |
GenBank Gene ID | Not Available |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:2016 |
Chromosome Location | 1 |
Locus | Not Available |
References |
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