T3DB: C-Jun-amino-terminal kinase-interacting protein 3

Name	C-Jun-amino-terminal kinase-interacting protein 3
Synonyms	JIP-3 JIP3 JNK MAP kinase scaffold protein 3 KIAA1066 Mitogen-activated protein kinase 8-interacting protein 3
Gene Name	MAPK8IP3
Organism	Human
Amino acid sequence	>lcl\|BSEQ0008777\|C-Jun-amino-terminal kinase-interacting protein 3 MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK AERSHIIVWQVSYTPE
Number of residues	1336
Molecular Weight	147455.935
Theoretical pI	Not Available
GO Classification	Functions kinesin binding MAP-kinase scaffold activity receptor signaling complex scaffold activity JUN kinase binding Processes in utero embryonic development regulation of JNK cascade axon guidance activation of JUN kinase activity post-embryonic development regulation of gene expression forebrain development protein localization respiratory gaseous exchange lung alveolus development vesicle-mediated transport lung morphogenesis Components Golgi membrane dendrite axolemma smooth endoplasmic reticulum cytoplasm
General Function	Receptor signaling complex scaffold activity
Specific Function	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
Pfam Domain Function	JIP_LZII (PF16471 ) Jnk-SapK_ap_N (PF09744 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	Q9UPT6
UniProtKB Entry Name	JIP3_HUMAN
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0013410\|C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3) ATGATGGAGATCCAGATGGACGAGGGCGGCGGCGTGGTGGTGTACCAGGACGACTACTGC TCCGGCTCGGTGATGTCGGAGCGGGTGTCGGGCCTGGCGGGCTCCATCTACCGCGAGTTC GAGCGCCTCATCCACTGCTACGACGAGGAGGTGGTCAAGGAGCTCATGCCGCTGGTGGTG AACGTGCTGGAGAACCTAGACTCGGTGCTCAGCGAGAACCAGGAGCACGAGGTGGAGCTG GAGCTGCTGCGCGAGGACAACGAGCAGCTGCTCACCCAGTACGAGCGTGAGAAGGCGCTG CGCAGGCAGGCGGAGGAGAAATTCATTGAGTTTGAAGATGCTCTGGAACAAGAGAAGAAA GAGCTGCAAATCCAGGTGGAGCACTACGAGTTCCAGACGCGCCAGCTGGAGCTGAAGGCC AAGAACTATGCCGATCAGATTTCCCGGTTGGAGGAGCGGGAGTCGGAGATGAAGAAGGAG TACAATGCCCTGCACCAGCGGCACACAGAGATGATACAGACCTACGTGGAGCACATTGAG AGGTCCAAGATGCAGCAGGTCGGAGGAAACAGCCAGACCGAGAGCAGCCTGCCGGGGCGG AGGAAGGAGCGCCCCACCTCCCTGAACGTGTTCCCCCTGGCTGACGGCACGGTACGTGCA CAGATCGGGGGCAAGCTCGTGCCTGCGGGGGACCACTGGCACCTGAGTGACCTCGGCCAG CTGCAGTCCAGCTCCAGCTACCAGTGTCCACAGGATGAAATGTCCGAGTCAGGCCAGTCC TCGGCGGCCGCCACACCCAGCACCACAGGCACCAAGTCCAACACGCCCACATCCTCCGTG CCCTCGGCCGCCGTCACACCCCTCAACGAGAGCCTGCAGCCCCTGGGGGACTATGGCGTG GGCTCCAAGAACAGCAAGCGTGCCCGGGAGAAGCGCGACAGCCGCAACATGGAAGTACAG GTCACCCAGGAGATGCGCAACGTCAGTATAGGCATGGGCAGCAGTGACGAGTGGTCTGAT GTTCAAGACATTATTGACTCCACGCCAGAGCTGGACATGTGTCCAGAGACCCGCCTGGAC CGCACAGGAAGCAGCCCAACCCAGGGCATCGTGAACAAAGCTTTCGGCATCAACACCGAC TCCCTGTACCATGAGCTGTCGACGGCAGGGTCTGAGGTCATCGGGGATGTGGACGAAGGG GCCGACCTCCTAGGGGAGTTCTCAGGAATGGGCAAAGAAGTGGGGAATCTGCTACTGGAA AACTCACAGCTTCTGGAAACCAAAAACGCCTTGAATGTGGTGAAGAATGACCTGATTGCC AAGGTCGACCAGCTGTCCGGGGAGCAGGAGGTGCTGAGGGGCGAGTTGGAGGCTGCTAAG CAGGCCAAAGTCAAGCTGGAAAACCGTATCAAGGAGCTGGAAGAGGAACTGAAAAGAGTG AAGTCCGAGGCCATCATCGCCCGCCGTGAACCCAAAGAAGAGGCGGAGGATGTAAGCAGC TATCTCTGTACAGAATCGGACAAAATCCCCATGGCCCAGCGCCGCCGCTTCACGCGGGTG GAGATGGCCCGTGTGCTCATGGAGCGGAACCAGTACAAGGAGCGGCTGATGGAGCTGCAG GAGGCTGTGCGGTGGACTGAGATGATCAGAGCGTCCCGAGAGCACCCATCCGTCCAGGAG AAGAAGAAGTCGACCATCTGGCAGTTCTTCAGCCGCCTCTTCAGCTCTTCCTCCAGCCCC CCTCCGGCCAAGCGCCCCTATCCCTCGGTGAACATCCACTACAAGTCACCCACCACTGCC GGCTTCAGCCAGCGCCGCAACCATGCCATGTGCCCGATCTCGGCAGGCAGCCGGCCCCTG GAATTCTTCCCTGACGACGACTGCACGTCCTCCGCCCGTCGAGAGCAGAAGCGCGAGCAG TACCGCCAGGTGCGTGAGCACGTGCGTAACGACGACGGCCGTCTGCAGGCCTGCGGCTGG AGCCTGCCCGCCAAGTACAAGCAGCTGAGTCCCAACGGGGGCCAGGAGGACACGCGGATG AAGAACGTGCCGGTGCCGGTGTACTGCCGCCCTCTGGTGGAGAAGGACCCCACCATGAAG CTGTGGTGTGCCGCGGGCGTCAACCTGAGCGGGTGGAGGCCCAATGAGGACGACGCTGGG AATGGAGTCAAGCCAGCGCCAGGCCGCGATCCCCTGACCTGCGACCGCGAAGGAGACGGC GAGCCCAAGAGCGCCCACACGTCTCCCGAGAAGAAGAAGGCCAAGGAGCTCCCTGAAATG GACGCCACCTCCAGCCGGGTGTGGATCCTGACCAGCACCCTGACCACCAGCAAGGTGGTG ATCATCGACGCCAACCAGCCGGGCACGGTGGTGGACCAGTTCACCGTCTGCAACGCGCAC GTGCTGTGCATCTCCAGCATCCCCGCGGCCAGCGACAGCGACTACCCTCCCGGGGAGATG TTCCTGGACAGCGACGTGAACCCAGAGGACCCGGGCGCAGATGGCGTGCTGGCCGGTATC ACCCTGGTGGGCTGTGCCACCCGCTGCAACGTGCCGCGGAGCAACTGCTCCTCCCGAGGG GACACCCCAGTGCTAGACAAGGGGCAGGGGGAGGTGGCCACCATCGCCAACGGGAAGGTC AACCCGTCCCAGTCCACAGAGGAGGCCACAGAGGCCACGGAGGTGCCAGACCCTGGGCCC AGCGAGCCAGAGACAGCCACATTGCGGCCCGGGCCTCTCACAGAGCACGTCTTCACTGAC CCAGCCCCGACCCCGTCCTCTGGCCCCCAGCCTGGCAGCGAGAACGGGCCAGAGCCTGAC AGCAGCAGCACACGGCCAGAGCCAGAGCCCAGCGGGGACCCCACGGGAGCAGGCAGCAGT GCTGCACCCACCATGTGGCTGGGAGCCCAGAACGGCTGGCTCTATGTGCACTCGGCTGTG GCCAACTGGAAGAAGTGCCTGCACTCCATCAAGCTGAAGGATTCTGTGCTGAGCCTGGTG CATGTCAAAGGCCGTGTGCTGGTGGCTCTGGCGGACGGGACCCTGGCCATCTTCCACCGT GGTGAAGATGGCCAGTGGGATCTGAGCAACTATCACCTAATGGACCTGGGCCACCCGCAC CACTCCATCCGCTGCATGGCTGTTGTGTACGACCGCGTGTGGTGTGGCTACAAGAACAAG GTGCACGTCATCCAGCCCAAGACCATGCAGATAGAGAAGTCATTTGACGCCCACCCGCGG CGGGAGAGCCAGGTGCGGCAGCTGGCGTGGATCGGCGATGGCGTATGGGTGTCCATCCGC CTGGACTCCACCCTGAGGCTCTACCATGCACACACGCACCAGCATCTACAGGACGTGGAC ATTGAGCCCTACGTCAGCAAGATGCTAGGCACTGGCAAGCTGGGTTTCTCCTTCGTACGC ATCACGGCCCTGCTTGTCGCGGGCAGCCGGCTCTGGGTGGGCACCGGCAACGGAGTGGTC ATCTCCATCCCCCTGACAGAGACTGTGGTCCTGCACCGAGGCCAGCTCCTGGGGCTCCGA GCCAATAAGACATCCCCCACCTCTGGGGAGGGCGCCCGTCCCGGGGGCATCATCCACGTG TATGGCGATGACAGCAGTGACAGGGCGGCCAGCAGCTTCATCCCCTACTGCTCCATGGCC CAGGCCCAGCTATGCTTCCATGGGCACCGCGATGCCGTGAAGTTCTTTGTCTCGGTGCCA GGGAACGTGCTGGCCACCCTGAATGGGAGTGTGCTGGACAGCCCAGCCGAGGGCCCTGGG CCAGCTGCCCCTGCCTCGGAGGTCGAGGGCCAGAAGCTGCGGAACGTGCTGGTGCTGAGC GGCGGGGAGGGCTACATCGACTTCCGCATTGGAGACGGAGAGGACGACGAGACGGAGGAG GGCGCAGGGGACATGAGCCAGGTGAAGCCCGTGCTGTCCAAGGCAGAGCGCAGTCACATC ATCGTGTGGCAGGTGTCCTACACCCCCGAGTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:6884
Chromosome Location	16
Locus	Not Available
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