T3DB: Neurexin-1

Name	Neurexin-1
Synonyms	KIAA0578 Neurexin I-alpha Neurexin-1-alpha
Gene Name	NRXN1
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009036\|Neurexin-1 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQG QPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTS IMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTR AGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRN YISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
Number of residues	1477
Molecular Weight	161881.53
Theoretical pI	Not Available
GO Classification	Functions calcium channel regulator activity acetylcholine receptor binding neuroligin family protein binding receptor activity calcium ion binding cell adhesion molecule binding Processes positive regulation of synapse assembly neurotransmitter secretion positive regulation of synaptic transmission, glutamatergic axon guidance regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of synapse maturation extracellular matrix organization learning social behavior regulation of grooming behavior vocalization behavior gephyrin clustering involved in postsynaptic density assembly neuroligin clustering involved in postsynaptic membrane assembly neuromuscular process controlling balance neuron cell-cell adhesion adult behavior postsynaptic density protein 95 clustering synapse assembly synaptic transmission postsynaptic membrane assembly positive regulation of excitatory postsynaptic potential vocal learning prepulse inhibition Components cell junction nuclear membrane integral component of plasma membrane neuronal cell body protein complex presynaptic membrane endoplasmic reticulum plasma membrane cell surface vesicle
General Function	Receptor activity
Specific Function	Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).
Pfam Domain Function	EGF (PF00008 ) Laminin_G_2 (PF02210 ) Syndecan (PF01034 )
Transmembrane Regions	1402-1422
GenBank Protein ID	Not Available
UniProtKB ID	Q9ULB1
UniProtKB Entry Name	NRX1A_HUMAN
Cellular Location	Cell membrane
Gene sequence	>lcl\|BSEQ0021961\|Neurexin-1 (NRXN1) ATGGGGACGGCGCTGCTCCAGCGCGGGGGCTGTTTTCTTCTGTGCCTCTCGCTGCTGCTC CTGGGCTGCTGGGCGGAGCTGGGCAGCGGGCTGGAGTTTCCGGGCGCCGAGGGCCAATGG ACGCGCTTCCCCAAGTGGAACGCCTGCTGCGAGAGCGAGATGAGCTTCCAGCTCAAGACT CGCAGCGCCCGCGGCCTCGTGCTCTACTTCGACGACGAGGGCTTCTGCGACTTCCTGGAG CTGATTCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCTCCATCTTCTGCGCTGAGCCT GCGACGCTCCTGGCCGACACGCCGGTTAACGACGGCGCCTGGCACAGCGTGCGCATCCGC CGCCAGTTCCGCAACACCACGCTCTTCATCGACCAGGTGGAGGCCAAGTGGGTGGAGGTC AAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGCCTTTTCGTCGGGGGGCTGCCCCCG GAACTGCGCGCCGCGGCGCTCAAGCTCACCCTGGCCTCGGTGAGGGAGCGGGAGCCCTTC AAGGGGTGGATTCGTGACGTGAGGGTCAACTCCTCGCAGGTCCTGCCCGTGGACAGCGGC GAGGTGAAGCTGGACGATGAGCCGCCCAACAGCGGCGGGGGAAGCCCGTGCGAGGCGGGC GAGGAGGGCGAGGGCGGGGTGTGCCTCAACGGAGGTGTGTGCTCCGTGGTGGACGACCAG GCCGTGTGCGACTGCTCGCGAACCGGCTTCCGCGGCAAGGACTGCAGCCAAGAAATAAAA TTCGGTCTTCAGTGTGTTTTGCCGGTGCTGTTACATGACAATGACCAAGGAAAATACTGT TGTATAAATACAGCAAAGCCTCTAACAGAAAAAGACAACAATGTGGAAGGTCTGGCGCAC CTGATGATGGGCGACCAAGGTAAAAGTAAAGGAAAAGAAGAATATATTGCCACGTTCAAA GGATCTGAATACTTCTGCTACGACTTGTCTCAAAACCCCATTCAAAGCAGCAGTGATGAA ATAACTCTGTCATTTAAAACCCTTCAGAGGAATGGACTGATGCTTCACACTGGGAAATCG GCTGATTATGTCAATCTTGCCCTGAAAAATGGAGCTGTCTCTCTGGTCATTAATTTGGGA TCAGGGGCCTTTGAAGCACTAGTGGAGCCTGTGAATGGAAAGTTTAATGATAATGCCTGG CATGATGTGAAAGTCACCAGGAATCTGCGTCAGCACTCAGGCATTGGACACGCTATGGTA AACAAACTACATTGTTCGGTGACAATATCAGTGGATGGGATTCTTACCACAACGGGCTAC ACGCAAGAAGATTATACCATGCTGGGGTCTGATGACTTTTTCTATGTTGGAGGCAGTCCC AGCACAGCCGACCTTCCAGGGTCACCAGTCAGTAACAACTTTATGGGCTGTCTCAAAGAG GTTGTATATAAAAATAATGATGTGAGGCTGGAATTATCTCGACTTGCCAAGCAAGGAGAT CCTAAGATGAAGATCCATGGAGTGGTGGCATTTAAATGTGAGAATGTTGCAACTTTAGAC CCAATCACCTTTGAAACCCCAGAGTCTTTCATCTCTTTGCCTAAATGGAATGCAAAGAAA ACTGGCTCCATATCATTTGATTTCCGTACAACAGAGCCAAATGGCCTCATCTTATTTAGC CATGGCAAGCCAAGACATCAGAAAGATGCCAAGCACCCACAGATGATAAAGGTGGACTTC TTTGCTATTGAGATGCTAGATGGCCACCTCTACCTCCTCCTGGACATGGGGTCAGGTACT ATAAAAATAAAAGCCCTGTTGAAGAAAGTGAATGATGGAGAATGGTATCATGTGGACTTC CAGAGAGACGGACGGTCAGGTACCATTTCTGTCAACACGTTGCGTACTCCCTACACTGCT CCTGGTGAGAGTGAGATTCTGGACCTGGATGATGAGTTGTACCTGGGGGGGCTGCCAGAA AATAAAGCTGGCCTTGTCTTCCCCACCGAGGTGTGGACTGCTCTGCTCAACTATGGCTAC GTGGGCTGCATCAGGGATTTGTTCATCGATGGCCAAAGCAAAGATATCCGGCAAATGGCT GAAGTTCAAAGTACTGCTGGAGTGAAGCCTTCCTGCTCAAAGGAAACAGCAAAACCGTGC CTTAGCAACCCTTGCAAAAACAATGGCATGTGCAGGGATGGGTGGAACAGATATGTCTGT GATTGTTCCGGAACAGGCTATCTTGGCAGGTCCTGTGAGAGAGAGGCAACGGTTTTGAGC TATGATGGGAGCATGTTTATGAAAATTCAGCTCCCCGTAGTCATGCATACGGAGGCTGAG GATGTTTCCTTACGGTTCCGATCCCAGCGTGCATATGGCATTCTGATGGCAACCACTTCT AGAGACTCTGCTGACACCCTCCGCCTGGAGCTAGACGCAGGACGTGTGAAACTGACGGTC AATCTAGATTGTATCAGGATTAACTGTAATTCCAGCAAAGGTCCCGAGACTCTTTTTGCT GGCTATAACCTCAATGATAACGAGTGGCACACAGTGCGTGTAGTTCGGCGTGGAAAAAGT TTAAAGTTAACAGTGGATGACCAACAGGCCATGACAGGTCAAATGGCAGGTGATCATACT AGGCTGGAGTTCCATAACATAGAGACTGGCATCATCACAGAACGACGGTATCTTTCTTCT GTCCCCTCCAACTTCATTGGACACCTGCAGAGCTTGACATTTAATGGAATGGCATACATT GACCTGTGTAAAAATGGCGACATAGATTACTGTGAGCTTAATGCCAGATTTGGCTTCAGG AACATCATAGCAGATCCTGTCACCTTCAAGACCAAATCGAGCTATGTTGCCTTAGCTACC TTGCAAGCCTACACTTCTATGCATCTTTTTTTCCAGTTCAAGACAACATCCCTAGATGGA TTAATTCTATATAACAGTGGGGATGGAAATGACTTTATTGTGGTTGAATTAGTTAAAGGG TACTTACATTACGTGTTTGATTTGGGAAATGGTGCTAACCTCATCAAAGGAAGCTCAAAT AAACCTCTCAATGACAATCAGTGGCACAACGTGATGATATCAAGGGACACCAGCAACCTC CACACTGTAAAGATTGACACAAAAATCACAACGCAAATCACCGCCGGAGCCAGGAACTTA GACCTCAAGAGTGACTTATATATAGGAGGAGTAGCTAAAGAAACATACAAATCCTTACCA AAACTTGTACATGCCAAAGAAGGCTTTCAAGGCTGCCTGGCATCAGTTGATTTAAATGGA CGGCTTCCGGACCTCATCTCCGATGCTCTTTTCTGCAACGGACAGATCGAGAGAGGATGT GAAGGGCCCAGCACAACCTGCCAAGAGGACTCATGTTCCAATCAAGGTGTGTGCTTGCAA CAATGGGATGGCTTCAGCTGTGACTGTAGTATGACTTCCTTCAGTGGACCACTCTGCAAT GACCCTGGGACGACATATATCTTTAGCAAAGGTGGTGGACAAATCACGTATAAGTGGCCT CCTAATGACCGACCCAGTACACGAGCAGACAGACTGGCCATAGGTTTTAGCACTGTTCAG AAAGAAGCCGTATTGGTGCGAGTGGACAGTTCTTCAGGCTTGGGTGACTACCTAGAACTG CATATACACCAGGGAAAAATTGGAGTTAAGTTTAATGTTGGGACAGATGACATCGCCATT GAAGAATCCAATGCAATCATTAATGATGGGAAATACCATGTAGTTCGTTTCACGAGGAGT GGTGGCAATGCCACGTTGCAGGTGGACAGCTGGCCAGTGATCGAGCGCTACCCTGCAGGA AACAATGATAACGAGCGCCTGGCGATTGCTAGACAGCGAATTCCATATCGACTTGGTCGA GTAGTTGATGAATGGCTACTCGACAAAGGGCGTCAGCTCACAATCTTCAATAGCCAAGCA ACCATAATAATTGGCGGGAAAGAGCAGGGCCAGCCCTTCCAGGGCCAGCTCTCTGGGCTG TACTACAATGGCTTGAAAGTTCTGAATATGGCAGCCGAAAACGATGCCAACATCGCCATA GTGGGAAATGTGAGACTGGTTGGTGAAGTGCCTTCCTCTATGACAACTGAGTCAACAGCC ACTGCCATGCAATCAGAGATGTCCACATCAATTATGGAGACTACCACGACCCTGGCTACT AGCACAGCCAGAAGAGGAAAGCCCCCGACAAAAGAACCCATTAGCCAGACCACAGATGAC ATCCTTGTGGCCTCAGCAGAGTGTCCCAGCGATGATGAGGACATTGACCCCTGTGAGCCG AGCTCAGGTGGGTTAGCCAACCCAACCCGAGCAGGCGGCAGAGAGCCGTATCCAGGCTCA GCAGAAGTGATCCGGGAGTCCAGCAGCACCACGGGTATGGTCGTTGGGATAGTAGCCGCT GCCGCCCTGTGCATCCTTATCCTCCTCTATGCCATGTACAAGTACAGAAACCGGGATGAA GGCTCATACCATGTGGACGAGAGTCGAAACTACATCAGTAACTCAGCACAGTCCAATGGG GCTGTTGTAAAGGAGAAACAACCCAGCAGTGCGAAAAGCTCCAACAAAAATAAGAAAAAC AAGGATAAAGAGTATTATGTCTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:8008
Chromosome Location	2
Locus	Not Available
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