Peroxisomal carnitine O-octanoyltransferase
Name | Peroxisomal carnitine O-octanoyltransferase |
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Synonyms |
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Gene Name | CROT |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0000743|Peroxisomal carnitine O-octanoyltransferase MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQS GIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGT QLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNYF RTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDGPGIAAL TSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIG DPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGRWKGSEKVR DIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFI QLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQ QKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFV LSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRFVVACSAWKSCPETDAEKLVQLTFCAF HDMIQLMNSTHL |
Number of residues | 612 |
Molecular Weight | 70177.935 |
Theoretical pI | 7.09 |
GO Classification | Functions
Processes
Components
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General Function | Receptor binding |
Specific Function | Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. |
Pfam Domain Function |
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Transmembrane Regions | Not Available |
GenBank Protein ID | 6066280 |
UniProtKB ID | Q9UKG9 |
UniProtKB Entry Name | OCTC_HUMAN |
Cellular Location | Peroxisome |
Gene sequence | >lcl|BSEQ0016074|Peroxisomal carnitine O-octanoyltransferase (CROT) ATGGAAAATCAATTGGCTAAATCAACTGAAGAACGAACATTTCAGTACCAGGATTCTCTT CCATCACTGCCTGTTCCTTCACTTGAAGAATCATTAAAAAAATACCTTGAATCAGTCACC AGAACATGCTACCAGATAAGGGGTCTTGATCCAGATGCTAAGAGAGGGTTCTTGGATCTC ACGCGGGAAGGAATTCAAGTGAAACCATTTGCAAATCAAGAAGAATATAAGAAAACTGAA GAAATAGTTCAAAAATTTCAAAGTGGGATTGGAGAAAAATTGCACCAGAAATTGCTTGAA AGAGCAAAAGGAAAAAGAAATTGGCTGGAAGAGTGGTGGCTGAATGTTGCCTATCTGGAT GTTCGTATACCATCACAATTGAATGTCAACTTTGCGGGTCCTGCAGCTCATTTTGAACAC TACTGGCCTCCAAAGGAAGGGACTCAATTAGAAAGAGGAAGTATAACTCTTTGGCATAAC TTGAACTACTGGCAGCTATTAAGAAAAGAAAAAGTGCCTGTTCATAAAGTTGGAAATACT CCTCTAGATATGAATCAATTCCGAATGCTATTTTCTACCTGCAAGGTTCCAGGAATTACT AGAGACTCCATTATGAATTATTTTAGGACTGAGAGTGAAGGGCGTTCCCCAAACCACATT GTAGTGCTGTGTCGAGGCCGAGCTTTTGTCTTTGATGTAATACATGAAGGATGTTTGGTC ACCCCGCCAGAGCTTCTCAGACAACTGACATATATCCACAAGAAGTGCCATAGTGAACCT GATGGACCTGGGATTGCAGCATTAACTAGTGAGGAGCGAACTCGATGGGCTAAGGCACGA GAATATCTGATTGGTCTTGATCCAGAGAACTTGGCTTTGTTAGAAAAAATTCAGAGTAGT TTACTGGTATATTCCATGGAGGATAGCAGTCCACATGTAACACCAGAGGATTATTCTGAG ATTATTGCAGCCATCCTTATTGGAGATCCAACAGTACGCTGGGGTGACAAATCCTATAAC TTGATTTCCTTTTCTAATGGAGTATTTGGCTGTAATTGTGATCATGCTCCTTTTGATGCA ATGATTATGGTGAACATCAGTTATTATGTGGATGAGAAAATTTTTCAGAATGAAGGAAGA TGGAAGGGTTCAGAGAAGGTACGAGATATACCACTTCCAGAAGAGCTCATTTTCATTGTG GATGAGAAAGTTTTAAATGACATCAACCAAGCTAAAGCCCAGTATCTCAGGGAGGCATCT GATCTACAGATTGCGGCTTATGCCTTTACATCTTTTGGCAAAAAGCTAACCAAGAACAAG ATGCTTCACCCGGATACGTTTATTCAGCTTGCACTTCAGCTGGCCTATTACAGACTTCAT GGACACCCTGGTTGTTGCTATGAAACAGCTATGACAAGACATTTTTATCATGGCCGTACA GAGACTATGCGATCATGCACAGTTGAAGCAGTGAGGTGGTGCCAGTCCATGCAGGATCCT TCTGTCAATCTTCGTGAGCGGCAGCAAAAGATGTTACAAGCTTTTGCAAAGCATAATAAA ATGATGAAAGATTGTTCAGCTGGAAAAGGATTTGATCGTCACCTTTTAGGTCTCTTACTC ATAGCAAAAGAGGAAGGTCTTCCTGTTCCAGAACTCTTTACGGACCCACTTTTTTCCAAA AGCGGAGGAGGTGGAAATTTTGTTCTCTCAACAAGTCTGGTTGGCTATTTACGAGTCCAG GGAGTGGTAGTTCCCATGGTACACAATGGTTATGGATTTTTCTACCATATCAGAGATGAC AGGTTTGTTGTGGCCTGTTCAGCCTGGAAATCCTGTCCCGAGACTGATGCGGAAAAGCTA GTTCAGCTGACTTTTTGTGCTTTTCATGATATGATACAGCTGATGAACTCTACTCATCTT TAG |
GenBank Gene ID | AF168793 |
GeneCard ID | Not Available |
GenAtlas ID | CROT |
HGNC ID | HGNC:2366 |
Chromosome Location | 7 |
Locus | 7q21.1 |
References |
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