NameLeucine carboxyl methyltransferase 1
Synonyms
  • [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
  • 2.1.1.233
  • LCMT
  • Protein-leucine O-methyltransferase
Gene NameLCMT1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000897|Leucine carboxyl methyltransferase 1
MATRQRESSITSCCSTSSCDADDEGVRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLSKE
RKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKDEDLLPSKYFE
VDFPMIVTRKLHSIKCKPPLSSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEE
KLKKCNMNTQLPTLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQI
MIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMMELYNRLPRAEVSRIESLE
FLDEMELLEQLMRHYCLCWATKGGNELGLKEITY
Number of residues334
Molecular Weight38378.695
Theoretical pI5.91
GO Classification
Functions
  • protein C-terminal carboxyl O-methyltransferase activity
  • protein C-terminal leucine carboxyl O-methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
Processes
  • cellular protein modification process
  • negative regulation of protein complex assembly
  • C-terminal protein methylation
  • protein methylation
  • regulation of glucose metabolic process
  • regulation of mitotic cell cycle spindle assembly checkpoint
  • regulation of apoptotic process
Components
  • cytosol
General FunctionS-adenosylmethionine-dependent methyltransferase activity
Specific FunctionMethylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID6580758
UniProtKB IDQ9UIC8
UniProtKB Entry NameLCMT1_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0010314|Leucine carboxyl methyltransferase 1 (LCMT1)
ATGGCCACTAGGCAGAGGGAATCCTCTATCACCTCCTGCTGTTCCACCTCGAGCTGCGAC
GCAGACGACGAGGGCGTGCGCGGCACCTGCGAAGATGCTTCCCTGTGCAAGAGGTTTGCA
GTAAGCATTGGCTACTGGCATGACCCTTACATACAGCACTTTGTGAGACTGTCTAAAGAG
AGGAAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTT
ATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTTGGGGCAGGC
ATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCTCCCAAGTAAATATTTTGAG
GTTGACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATTGCCAACACTCCTG
ATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGG
GCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGAT
CGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTG
GAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACA
GCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGG
ATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTAC
TGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGATAACTTATTAA
GenBank Gene IDAF037601
GeneCard IDNot Available
GenAtlas IDLCMT1
HGNC IDHGNC:17557
Chromosome Location16
Locus16p12.3-16p12.1
References
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